MCA_06398_1

Protein

Length

279 amino acids

Gene name: SOU1

Description: Sorbose reductase SOU1

Browser: contigD:4097134-4097974+

RNA-seq: read pairs 12072, FPKM 532.7, percentile rank 94.4% (100% = highest expression)

Protein function

Annotation:		SOU1	Sorbose reductase SOU1
KEGG:	K17742	SOU1	sorbose reductase [EC:1.1.1.289]
EGGNOG:	0PJRP	FG06104.1	)-reductase
SGD closest match:	S000005146	SPS19	Peroxisomal 2,4-dienoyl-CoA reductase SPS19
CGD closest match:	CAL0000190633	SOU1	Sorbose reductase SOU1

Protein alignments

	%id	Aln length	E-value
MIA_03325_1	85.55%	256	4e-150	MIA_03325_1
A0A060SYF8_BLAAD	79.45%	253	7e-139	ARAD1C00858p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C00858g PE=4 SV=1
A0A167FW21_9ASCO	78.43%	255	6e-137	Sps19p OS=Sugiyamaella lignohabitans GN=SPS19 PE=4 SV=1
A0A0J9X6W3_GEOCN	78.12%	256	5e-133	Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA04s05103g PE=4 SV=1
SDR_YARLI	73.73%	255	7e-131	Probable NADP-dependent mannitol dehydrogenase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0B16192g PE=1 SV=1
A0A1E3PEL0_9ASCO	73.91%	253	4e-128	NAD(P)-binding protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47664 PE=4 SV=1
A0A1E4TI77_9ASCO	70.20%	255	5e-122	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_71235 PE=4 SV=1
SOU1_CANAL	70.04%	257	4e-114	Sorbose reductase SOU1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SOU1 PE=1 SV=1
UniRef50_C8ZHF1	53.28%	259	7e-90	EC1118_1O4_6612p n=5 Tax=Saccharomycetales TaxID=4892 RepID=C8ZHF1_YEAS8
SPS19_YEAST	33.33%	255	1e-20	Peroxisomal 2,4-dienoyl-CoA reductase SPS19 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SPS19 PE=1 SV=4

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1183

Protein family membership

Short-chain dehydrogenase/reductase SDR (IPR002347)

Domains and repeats

Domain
30 - 277
NAD(P)-binding domain (IPR016040)

1 50 100 150 200 250 279

Detailed signature matches

IPR002347

Short-chain dehydrogenase/reductase SDR
1. PR00080 (SDRFAMILY)
  
  110 - 121
  
  PRINTS
  PR00080 (SDRFAMILY)
  
  175 - 183
  
  PRINTS
  PR00080 (SDRFAMILY)
  
  187 - 206
  
  PRINTS
  PR00080 (SDRFAMILY)
2. PR00081 (GDHRDH)
  
  36 - 53
  
  PRINTS
  PR00081 (GDHRDH)
  
  110 - 121
  
  PRINTS
  PR00081 (GDHRDH)
  
  207 - 224
  
  PRINTS
  PR00081 (GDHRDH)
  
  240 - 260
  
  PRINTS
  PR00081 (GDHRDH)
  
  159 - 175
  
  PRINTS
  PR00081 (GDHRDH)
  
  187 - 206
  
  PRINTS
  PR00081 (GDHRDH)
IPR016040

NAD(P)-binding domain
1. SSF51735 (NAD(P)-bi...)
  
  30 - 277
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
IPR020904

Short-chain dehydrogenase/reductase, conserved site
1. PS00061 (ADH_SHORT)
  
  174 - 202
  
  PROSITE patterns
  PS00061 (ADH_SHORT)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

80 - 278

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)

27 - 79

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
PF13561 (adh_short_C2)

42 - 276

Pfam
PF13561 (adh_short_C2)
cd05352 (MDH-like_S...)

27 - 278

CDD
cd05352 (MDH-like_SDR_c)

Residue annotation

homotetramer inter...

27L

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

29L

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

30F

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

56Q

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

57A

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

126G

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

129I

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

130D

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

132P

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

134H

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

137W

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

141I

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

145L

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

146N

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

149Y

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

150Y

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

153K

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

157R

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

174S

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

175G

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

176H

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

177I

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

178V

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

180F

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

183M

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

185A

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

188N

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

189A

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

192A

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

193A

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

196H

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

197L

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

199A

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

200S

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

201L

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

203V

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

204E

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

205W

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

218Y

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

237S

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

238Y

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

239I

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

240P

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

241L

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

243R

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

244E

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

245G

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

246E

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

248Q

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

249E

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

251V

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

252G

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

253A

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

255I

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

256Y

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

261A

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

263T

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

264Y

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

265T

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

266T

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

268A

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

270I

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

271R

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

272V

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

273D

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

274G

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

275G

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)

278C

homotetramer interface
27L, 29L, 30F, 56Q, 57A, 126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 177I, 178V, 180F, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 203V, 204E, 205W, 218Y, 237S, 238Y, 239I, 240P, 241L, 243R, 244E, 245G, 246E, 248Q, 249E, 251V, 252G, 253A, 255I, 256Y, 261A, 263T, 264Y, 265T, 266T, 268A, 270I, 271R, 272V, 273D, 274G, 275G, 278C
CDD
cd05352 (MDH-like_SDR_c)
NADP binding site ...

41G

NADP binding site
41G, 43S, 44T, 45G, 46I, 64W, 65Y, 66N, 67S, 90V, 91Q, 92V, 118N, 119A, 120G, 143L, 170T, 171S, 172S, 187Y, 191K, 216P, 217G, 218Y, 219I, 221T, 222E
CDD
cd05352 (MDH-like_SDR_c)

43S

NADP binding site
41G, 43S, 44T, 45G, 46I, 64W, 65Y, 66N, 67S, 90V, 91Q, 92V, 118N, 119A, 120G, 143L, 170T, 171S, 172S, 187Y, 191K, 216P, 217G, 218Y, 219I, 221T, 222E
CDD
cd05352 (MDH-like_SDR_c)

44T

NADP binding site
41G, 43S, 44T, 45G, 46I, 64W, 65Y, 66N, 67S, 90V, 91Q, 92V, 118N, 119A, 120G, 143L, 170T, 171S, 172S, 187Y, 191K, 216P, 217G, 218Y, 219I, 221T, 222E
CDD
cd05352 (MDH-like_SDR_c)

45G

NADP binding site
41G, 43S, 44T, 45G, 46I, 64W, 65Y, 66N, 67S, 90V, 91Q, 92V, 118N, 119A, 120G, 143L, 170T, 171S, 172S, 187Y, 191K, 216P, 217G, 218Y, 219I, 221T, 222E
CDD
cd05352 (MDH-like_SDR_c)

46I

NADP binding site
41G, 43S, 44T, 45G, 46I, 64W, 65Y, 66N, 67S, 90V, 91Q, 92V, 118N, 119A, 120G, 143L, 170T, 171S, 172S, 187Y, 191K, 216P, 217G, 218Y, 219I, 221T, 222E
CDD
cd05352 (MDH-like_SDR_c)

64W

NADP binding site
41G, 43S, 44T, 45G, 46I, 64W, 65Y, 66N, 67S, 90V, 91Q, 92V, 118N, 119A, 120G, 143L, 170T, 171S, 172S, 187Y, 191K, 216P, 217G, 218Y, 219I, 221T, 222E
CDD
cd05352 (MDH-like_SDR_c)

65Y

NADP binding site
41G, 43S, 44T, 45G, 46I, 64W, 65Y, 66N, 67S, 90V, 91Q, 92V, 118N, 119A, 120G, 143L, 170T, 171S, 172S, 187Y, 191K, 216P, 217G, 218Y, 219I, 221T, 222E
CDD
cd05352 (MDH-like_SDR_c)

66N

NADP binding site
41G, 43S, 44T, 45G, 46I, 64W, 65Y, 66N, 67S, 90V, 91Q, 92V, 118N, 119A, 120G, 143L, 170T, 171S, 172S, 187Y, 191K, 216P, 217G, 218Y, 219I, 221T, 222E
CDD
cd05352 (MDH-like_SDR_c)

67S

NADP binding site
41G, 43S, 44T, 45G, 46I, 64W, 65Y, 66N, 67S, 90V, 91Q, 92V, 118N, 119A, 120G, 143L, 170T, 171S, 172S, 187Y, 191K, 216P, 217G, 218Y, 219I, 221T, 222E
CDD
cd05352 (MDH-like_SDR_c)

90V

NADP binding site
41G, 43S, 44T, 45G, 46I, 64W, 65Y, 66N, 67S, 90V, 91Q, 92V, 118N, 119A, 120G, 143L, 170T, 171S, 172S, 187Y, 191K, 216P, 217G, 218Y, 219I, 221T, 222E
CDD
cd05352 (MDH-like_SDR_c)

91Q

NADP binding site
41G, 43S, 44T, 45G, 46I, 64W, 65Y, 66N, 67S, 90V, 91Q, 92V, 118N, 119A, 120G, 143L, 170T, 171S, 172S, 187Y, 191K, 216P, 217G, 218Y, 219I, 221T, 222E
CDD
cd05352 (MDH-like_SDR_c)

92V

NADP binding site
41G, 43S, 44T, 45G, 46I, 64W, 65Y, 66N, 67S, 90V, 91Q, 92V, 118N, 119A, 120G, 143L, 170T, 171S, 172S, 187Y, 191K, 216P, 217G, 218Y, 219I, 221T, 222E
CDD
cd05352 (MDH-like_SDR_c)

118N

NADP binding site
41G, 43S, 44T, 45G, 46I, 64W, 65Y, 66N, 67S, 90V, 91Q, 92V, 118N, 119A, 120G, 143L, 170T, 171S, 172S, 187Y, 191K, 216P, 217G, 218Y, 219I, 221T, 222E
CDD
cd05352 (MDH-like_SDR_c)

119A

NADP binding site
41G, 43S, 44T, 45G, 46I, 64W, 65Y, 66N, 67S, 90V, 91Q, 92V, 118N, 119A, 120G, 143L, 170T, 171S, 172S, 187Y, 191K, 216P, 217G, 218Y, 219I, 221T, 222E
CDD
cd05352 (MDH-like_SDR_c)

120G

NADP binding site
41G, 43S, 44T, 45G, 46I, 64W, 65Y, 66N, 67S, 90V, 91Q, 92V, 118N, 119A, 120G, 143L, 170T, 171S, 172S, 187Y, 191K, 216P, 217G, 218Y, 219I, 221T, 222E
CDD
cd05352 (MDH-like_SDR_c)

143L

NADP binding site
41G, 43S, 44T, 45G, 46I, 64W, 65Y, 66N, 67S, 90V, 91Q, 92V, 118N, 119A, 120G, 143L, 170T, 171S, 172S, 187Y, 191K, 216P, 217G, 218Y, 219I, 221T, 222E
CDD
cd05352 (MDH-like_SDR_c)

170T

NADP binding site
41G, 43S, 44T, 45G, 46I, 64W, 65Y, 66N, 67S, 90V, 91Q, 92V, 118N, 119A, 120G, 143L, 170T, 171S, 172S, 187Y, 191K, 216P, 217G, 218Y, 219I, 221T, 222E
CDD
cd05352 (MDH-like_SDR_c)

171S

NADP binding site
41G, 43S, 44T, 45G, 46I, 64W, 65Y, 66N, 67S, 90V, 91Q, 92V, 118N, 119A, 120G, 143L, 170T, 171S, 172S, 187Y, 191K, 216P, 217G, 218Y, 219I, 221T, 222E
CDD
cd05352 (MDH-like_SDR_c)

172S

NADP binding site
41G, 43S, 44T, 45G, 46I, 64W, 65Y, 66N, 67S, 90V, 91Q, 92V, 118N, 119A, 120G, 143L, 170T, 171S, 172S, 187Y, 191K, 216P, 217G, 218Y, 219I, 221T, 222E
CDD
cd05352 (MDH-like_SDR_c)

187Y

NADP binding site
41G, 43S, 44T, 45G, 46I, 64W, 65Y, 66N, 67S, 90V, 91Q, 92V, 118N, 119A, 120G, 143L, 170T, 171S, 172S, 187Y, 191K, 216P, 217G, 218Y, 219I, 221T, 222E
CDD
cd05352 (MDH-like_SDR_c)

191K

NADP binding site
41G, 43S, 44T, 45G, 46I, 64W, 65Y, 66N, 67S, 90V, 91Q, 92V, 118N, 119A, 120G, 143L, 170T, 171S, 172S, 187Y, 191K, 216P, 217G, 218Y, 219I, 221T, 222E
CDD
cd05352 (MDH-like_SDR_c)

216P

NADP binding site
41G, 43S, 44T, 45G, 46I, 64W, 65Y, 66N, 67S, 90V, 91Q, 92V, 118N, 119A, 120G, 143L, 170T, 171S, 172S, 187Y, 191K, 216P, 217G, 218Y, 219I, 221T, 222E
CDD
cd05352 (MDH-like_SDR_c)

217G

NADP binding site
41G, 43S, 44T, 45G, 46I, 64W, 65Y, 66N, 67S, 90V, 91Q, 92V, 118N, 119A, 120G, 143L, 170T, 171S, 172S, 187Y, 191K, 216P, 217G, 218Y, 219I, 221T, 222E
CDD
cd05352 (MDH-like_SDR_c)

218Y

NADP binding site
41G, 43S, 44T, 45G, 46I, 64W, 65Y, 66N, 67S, 90V, 91Q, 92V, 118N, 119A, 120G, 143L, 170T, 171S, 172S, 187Y, 191K, 216P, 217G, 218Y, 219I, 221T, 222E
CDD
cd05352 (MDH-like_SDR_c)

219I

NADP binding site
41G, 43S, 44T, 45G, 46I, 64W, 65Y, 66N, 67S, 90V, 91Q, 92V, 118N, 119A, 120G, 143L, 170T, 171S, 172S, 187Y, 191K, 216P, 217G, 218Y, 219I, 221T, 222E
CDD
cd05352 (MDH-like_SDR_c)

221T

NADP binding site
41G, 43S, 44T, 45G, 46I, 64W, 65Y, 66N, 67S, 90V, 91Q, 92V, 118N, 119A, 120G, 143L, 170T, 171S, 172S, 187Y, 191K, 216P, 217G, 218Y, 219I, 221T, 222E
CDD
cd05352 (MDH-like_SDR_c)

222E

NADP binding site
41G, 43S, 44T, 45G, 46I, 64W, 65Y, 66N, 67S, 90V, 91Q, 92V, 118N, 119A, 120G, 143L, 170T, 171S, 172S, 187Y, 191K, 216P, 217G, 218Y, 219I, 221T, 222E
CDD
cd05352 (MDH-like_SDR_c)
homodimer interfac...

126G

homodimer interface
126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 178V, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 204E, 205W
CDD
cd05352 (MDH-like_SDR_c)

129I

homodimer interface
126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 178V, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 204E, 205W
CDD
cd05352 (MDH-like_SDR_c)

130D

homodimer interface
126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 178V, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 204E, 205W
CDD
cd05352 (MDH-like_SDR_c)

132P

homodimer interface
126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 178V, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 204E, 205W
CDD
cd05352 (MDH-like_SDR_c)

134H

homodimer interface
126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 178V, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 204E, 205W
CDD
cd05352 (MDH-like_SDR_c)

137W

homodimer interface
126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 178V, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 204E, 205W
CDD
cd05352 (MDH-like_SDR_c)

141I

homodimer interface
126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 178V, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 204E, 205W
CDD
cd05352 (MDH-like_SDR_c)

145L

homodimer interface
126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 178V, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 204E, 205W
CDD
cd05352 (MDH-like_SDR_c)

146N

homodimer interface
126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 178V, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 204E, 205W
CDD
cd05352 (MDH-like_SDR_c)

149Y

homodimer interface
126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 178V, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 204E, 205W
CDD
cd05352 (MDH-like_SDR_c)

150Y

homodimer interface
126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 178V, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 204E, 205W
CDD
cd05352 (MDH-like_SDR_c)

153K

homodimer interface
126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 178V, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 204E, 205W
CDD
cd05352 (MDH-like_SDR_c)

157R

homodimer interface
126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 178V, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 204E, 205W
CDD
cd05352 (MDH-like_SDR_c)

174S

homodimer interface
126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 178V, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 204E, 205W
CDD
cd05352 (MDH-like_SDR_c)

175G

homodimer interface
126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 178V, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 204E, 205W
CDD
cd05352 (MDH-like_SDR_c)

176H

homodimer interface
126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 178V, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 204E, 205W
CDD
cd05352 (MDH-like_SDR_c)

178V

homodimer interface
126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 178V, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 204E, 205W
CDD
cd05352 (MDH-like_SDR_c)

183M

homodimer interface
126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 178V, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 204E, 205W
CDD
cd05352 (MDH-like_SDR_c)

185A

homodimer interface
126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 178V, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 204E, 205W
CDD
cd05352 (MDH-like_SDR_c)

188N

homodimer interface
126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 178V, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 204E, 205W
CDD
cd05352 (MDH-like_SDR_c)

189A

homodimer interface
126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 178V, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 204E, 205W
CDD
cd05352 (MDH-like_SDR_c)

192A

homodimer interface
126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 178V, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 204E, 205W
CDD
cd05352 (MDH-like_SDR_c)

193A

homodimer interface
126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 178V, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 204E, 205W
CDD
cd05352 (MDH-like_SDR_c)

196H

homodimer interface
126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 178V, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 204E, 205W
CDD
cd05352 (MDH-like_SDR_c)

197L

homodimer interface
126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 178V, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 204E, 205W
CDD
cd05352 (MDH-like_SDR_c)

199A

homodimer interface
126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 178V, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 204E, 205W
CDD
cd05352 (MDH-like_SDR_c)

200S

homodimer interface
126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 178V, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 204E, 205W
CDD
cd05352 (MDH-like_SDR_c)

201L

homodimer interface
126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 178V, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 204E, 205W
CDD
cd05352 (MDH-like_SDR_c)

204E

homodimer interface
126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 178V, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 204E, 205W
CDD
cd05352 (MDH-like_SDR_c)

205W

homodimer interface
126G, 129I, 130D, 132P, 134H, 137W, 141I, 145L, 146N, 149Y, 150Y, 153K, 157R, 174S, 175G, 176H, 178V, 183M, 185A, 188N, 189A, 192A, 193A, 196H, 197L, 199A, 200S, 201L, 204E, 205W
CDD
cd05352 (MDH-like_SDR_c)
active site cd05352

144D

active site
144D, 172S, 187Y, 191K
CDD
cd05352 (MDH-like_SDR_c)

172S

active site
144D, 172S, 187Y, 191K
CDD
cd05352 (MDH-like_SDR_c)

187Y

active site
144D, 172S, 187Y, 191K
CDD
cd05352 (MDH-like_SDR_c)

191K

active site
144D, 172S, 187Y, 191K
CDD
cd05352 (MDH-like_SDR_c)

Protein sequence

>MCA_06398_1
MSEELKTITTGLGPLPTPAPKPASNALDLFSLKGKVAVISGSSTGIGYAVAEAYAQAGADVAIWYNSHNADAKAKALSEK
YNIKSKAYKVQVTSSDDVEKAINQAAEDFGKIDIFVANAGVPWTAGPMIDVPDHKEWNKVIDLDLNGAYYCAKFVGRIFK
KQGHGSLIFTSSMSGHIVNFPQMQAGYNAAKAAVRHLAASLAVEWSGFARVNSISPGYIATEISDFIPKDIKSKWWSYIP
LGREGEPQELVGAYIYLASDASTYTTGADIRVDGGYCCP

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component