Protein

MCA_06310_1

Length
199 amino acids

Gene name: CPR2

Description: Peptidyl-prolyl cis-trans isomerase B

Browser: contigD:3833530-3834130+

RNA-seq: read pairs 4725, FPKM 291.9, percentile rank 91.6% (100% = highest expression)

Protein function

Annotation:CPR2Peptidyl-prolyl cis-trans isomerase B
KEGG:K03768PPIB peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8]
EGGNOG:0PFKSCPR2PPIases accelerate the folding of proteins (By similarity)
SGD closest match:S000002562CPR1Peptidyl-prolyl cis-trans isomerase
CGD closest match:CAL0000183095CYP1Peptidyl-prolyl cis-trans isomerase

Protein alignments

%idAln lengthE-value
MIA_06308_172.45%1962e-90MIA_06308_1
A0A060T5R4_BLAAD78.44%1671e-83Peptidyl-prolyl cis-trans isomerase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B09416g PE=3 SV=1
A0A0J9XJA4_GEOCN77.14%1756e-83Peptidyl-prolyl cis-trans isomerase OS=Geotrichum candidum GN=BN980_GECA21s00538g PE=3 SV=1
UniRef50_Q7S7Z675.82%1826e-78Peptidyl-prolyl cis-trans isomerase B n=56 Tax=Dikarya TaxID=451864 RepID=PPIB_NEUCR
A0A170QYJ5_9ASCO66.50%1972e-78Peptidyl-prolyl cis-trans isomerase OS=Sugiyamaella lignohabitans GN=CPR5 PE=3 SV=1
A0A1E3PPS3_9ASCO64.47%1974e-78Peptidyl-prolyl cis-trans isomerase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45448 PE=3 SV=1
PPIB_YARLI65.99%1975e-74Peptidyl-prolyl cis-trans isomerase B OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=CPR2 PE=3 SV=1
CYPH_YEAST69.14%1623e-69Peptidyl-prolyl cis-trans isomerase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CPR1 PE=1 SV=3
A0A1E4TLR7_9ASCO63.68%1901e-67Peptidyl-prolyl cis-trans isomerase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_56309 PE=3 SV=1
PPIA_CANAL68.52%1627e-67Peptidyl-prolyl cis-trans isomerase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CYP1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1325

Protein family membership

Domains and repeats

  1. Domain
1 20 40 60 80 100 120 140 160 180 199

Detailed signature matches

  1. Family IPR024936
    Cyclophilin-type peptidyl-prolyl cis-trans isomerase
    1. PIRSF001467 (Peptid...)
  2. Domain IPR029000
    Cyclophilin-like domain
    1. SSF50891 (Cyclophil...)
    2. G3DSA:2.40.10...
  3. Domain IPR002130
    Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
    1. PF00160 (Pro_isomerase)
    2. PS50072 (CSA_PPIASE_2)
    3. PR00153 (CSAPPISMRASE)
  4. SITE IPR020892
    Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
    1. PS00170 (CSA_PPIASE_1)
Unintegrated signatures no IPR
Unintegrated signatures
  1. NON_CYTOPLASM... (N...)
  2. SIGNAL_PEPTIDE (Sig...)
  3. SIGNAL_PEPTID... (S...)
  4. SIGNAL_PEPTID... (S...)
  5. SIGNAL_PEPTID... (S...)
  6. SignalP-noTM
  7. TMhelix
  8. cd01926 (cyclophili...)

Residue annotation

  1. active site cd01926

Protein sequence

>MCA_06310_1
MKSVFSFVAVVLMALMATFQGVMAADPKITTKVFFDIEQQGTPLGRIVIGLYGDVVPKTAENFRALATGEKGYGYEGSIF
HRVIKQFMIQGGDFTRGDGTGGKSIYGPRFPDENFVLKHDKPGRLSMANAGKDTNGSQFFITTVPTPWLDGKHVVFGEVV
EGFDIVKKIENTRTAWGDKPVQVVKIAKSGVLPDKRSEL

GO term prediction

Biological Process

GO:0000413 protein peptidyl-prolyl isomerization
GO:0006457 protein folding

Molecular Function

GO:0003755 peptidyl-prolyl cis-trans isomerase activity

Cellular Component

None predicted.