Protein
MCA_06142_1
Length
384 amino acids
Gene name: CAK1
Description: Serine/threonine-protein kinase CAK1; cyclin-dependent kinase-activating kinase; required for passage through the cell cycle; in S. cerevisiae phosphorylates and activates Cdc28p.
Browser: contigD:3353689-3354926+
RNA-seq: read pairs 421, FPKM 13.5, percentile rank 31.7% (100% = highest expression)
Protein function
| Annotation: | CAK1 | Serine/threonine-protein kinase CAK1; cyclin-dependent kinase-activating kinase; required for passage through the cell cycle; in S. cerevisiae phosphorylates and activates Cdc28p. | |
|---|---|---|---|
| KEGG: | K07760 | CDK | cyclin-dependent kinase [EC:2.7.11.22] |
| EGGNOG: | 0PM4Q | CAK1 | K06667 serine threonine-protein kinase CAK1 EC 2.7.11.22 |
| SGD closest match: | S000001865 | CAK1 | Serine/threonine-protein kinase CAK1 |
| CGD closest match: | CAL0000191889 | CAK1 | Cyclin-dependent protein kinase-activating kinase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_04409_1 | 36.46% | 373 | 5e-81 | MIA_04409_1 |
| A0A0J9XL98_GEOCN | 38.67% | 375 | 1e-78 | Similar to Saccharomyces cerevisiae YFL029C CAK1 Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p OS=Geotrichum candidum GN=BN980_GECA27s00505g PE=4 SV=1 |
| UniRef50_A0A0J9XL98 | 38.67% | 375 | 3e-75 | Similar to Saccharomyces cerevisiae YFL029C CAK1 Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XL98_GEOCN |
| A0A167DNF8_9ASCO | 40.69% | 376 | 2e-76 | Cyclin-dependent protein kinase-activating kinase CAK1 OS=Sugiyamaella lignohabitans GN=CAK1 PE=4 SV=1 |
| A0A060T8E8_BLAAD | 33.97% | 368 | 1e-61 | ARAD1D10736p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D10736g PE=4 SV=1 |
| Q6CAU2_YARLI | 34.13% | 378 | 9e-58 | YALI0C24321p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C24321g PE=4 SV=1 |
| A0A1E3PIR8_9ASCO | 33.51% | 385 | 5e-57 | Kinase-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_51941 PE=4 SV=1 |
| CAK1_YEAST | 31.37% | 306 | 5e-35 | Serine/threonine-protein kinase CAK1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CAK1 PE=1 SV=1 |
| A0A1E4TMA3_9ASCO | 33.80% | 284 | 1e-31 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_56438 PE=4 SV=1 |
| A0A1D8PH53_CANAL | 29.30% | 215 | 1e-23 | Cyclin-dependent protein kinase-activating kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CAK1 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.2790
Protein family membership
None predicted.
Domains and repeats
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Domain
1
50
100
150
200
250
300
350
384
Detailed signature matches
no IPR
Unintegrated signatures
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CYTOPLASMIC_D... (C...)
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-
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NON_CYTOPLASM... (N...)
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TRANSMEMBRANE (Tran...)
Protein sequence
>MCA_06142_1 MKNVKEKLYTERSYIARGLFSEVYKAKNNNPSLNSDTLKVVALKITIPDDERPPHDSLKEARILERINLDRKQLKQYELN KTTEISSQNGLKHIIELLDSFKSEVDGFEDSLVLVFPYLPITLDQIISHYRKPIVKLFTDEISDHSNFEEEEDEELIPKW RNKLPTEISLSVIKQLALALTYLHENGIIHRDIKPQNILFERIPSIDDDPINVHLYLADFGISWIPPDNESKEPIDKKIT DVGSGTYRSPQLLFGRQTYTESVDMWAVGCIIGLLFSPNTIPLFLNKYSKESDIALIATIFETLGVPTIETWPEAANIPS FTHMNFQGLKPLEHDITSENAYSKIIPLAPRVIRTQVFPKLLTFDQNKRMTAPELVTKMNELFP
GO term prediction
Biological Process
GO:0006468 protein phosphorylation
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Cellular Component
None predicted.