MCA_06052_1

Protein

Length

497 amino acids

RNA-seq: read pairs 365, FPKM 9.1, percentile rank 24.3% (100% = highest expression)

Protein function

EGGNOG:	0PJ3T		mono-carboxylate
SGD closest match:	S000005479	MCH4	Probable transporter MCH4
CGD closest match:	CAL0000177667	orf19.6263	Uncharacterized protein

Protein alignments

	%id	Aln length	E-value
MIA_03436_1	44.08%	490	2e-128	MIA_03436_1
A0A0J9XH20_GEOCN	41.88%	499	1e-118	Similar to Saccharomyces cerevisiae YOL119C MCH4 Protein with similarity to mammalian monocarboxylate permeases OS=Geotrichum candidum GN=BN980_GECA17s00593g PE=4 SV=1
UniRef50_A0A0J9XH20	41.88%	499	2e-115	Similar to Saccharomyces cerevisiae YOL119C MCH4 Protein with similarity to mammalian monocarboxylate permeases n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XH20_GEOCN
A0A060TFW4_BLAAD	49.76%	211	3e-69	ARAD1D17842p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D17842g PE=4 SV=1
Q6CEH9_YARLI	44.70%	217	1e-54	YALI0B15488p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B15488g PE=4 SV=1
A0A1E3PKI5_9ASCO	28.28%	435	2e-39	MFS general substrate transporter (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83425 PE=4 SV=1
A0A167FRE1_9ASCO	36.74%	215	3e-34	Mch5p OS=Sugiyamaella lignohabitans GN=MCH5 PE=4 SV=1
MCH4_YEAST	26.65%	454	7e-30	Probable transporter MCH4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MCH4 PE=1 SV=1
Q5AAP8_CANAL	26.48%	457	1e-25	Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.6263 PE=4 SV=1
A0A1E4TCK1_9ASCO	30.69%	189	1e-21	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_32724 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0625

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
16 - 492
Major facilitator superfamily domain (IPR020846)

1 50 100 150 200 250 300 350 400 450 497

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  70 - 446
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. PS50850 (MFS)
  
  31 - 492
  
  PROSITE profiles
  PS50850 (MFS)
2. SSF103473 (MFS gene...)
  
  287 - 486
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
  
  16 - 216
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
3. cd06174 (MFS)
  
  32 - 487
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

415 - 434

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

210 - 307

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

146 - 156

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 31

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

488 - 497

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

363 - 368

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

94 - 99

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

294 - 493

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

10 - 240

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

329 - 339

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

389 - 393

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

178 - 188

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

51 - 69

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

456 - 466

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

120 - 124

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

192 - 209

TMHMM
TMhelix (TMhelix)

96 - 118

TMHMM
TMhelix (TMhelix)

467 - 489

TMHMM
TMhelix (TMhelix)

125 - 147

TMHMM
TMhelix (TMhelix)

157 - 179

TMHMM
TMhelix (TMhelix)

31 - 53

TMHMM
TMhelix (TMhelix)

433 - 455

TMHMM
TMhelix (TMhelix)

340 - 362

TMHMM
TMhelix (TMhelix)

372 - 389

TMHMM
TMhelix (TMhelix)

396 - 418

TMHMM
TMhelix (TMhelix)

70 - 92

TMHMM
TMhelix (TMhelix)

305 - 327

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

394 - 414

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

100 - 119

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

308 - 328

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

32 - 50

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

369 - 388

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

435 - 455

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

125 - 145

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

157 - 177

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

467 - 487

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

70 - 93

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

189 - 209

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

340 - 362

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
mobidb-lite (disord...)

217 - 238

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 23

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative substrate...

46Y

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

49I

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

50N

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

51A

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

53G

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

54Q

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

75G

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

78Q

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

79P

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

82V

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

86S

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

87V

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

89A

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

90V

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

137L

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

138G

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

141C

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

142F

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

145F

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

146S

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

149Q

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

160V

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

161G

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

164A

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

165S

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

171G

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

317F

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

320L

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

321F

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

324L

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

325F

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

328P

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

341Y

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

345L

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

349N

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

352S

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

356R

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

404G

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

407S

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

408G

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

411I

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

415P

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

416S

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

419G

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

430R

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

431L

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

434M

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

435F

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

438N

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

439A

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

442S

putative substrate translocation pore
46Y, 49I, 50N, 51A, 53G, 54Q, 75G, 78Q, 79P, 82V, 86S, 87V, 89A, 90V, 137L, 138G, 141C, 142F, 145F, 146S, 149Q, 160V, 161G, 164A, 165S, 171G, 317F, 320L, 321F, 324L, 325F, 328P, 341Y, 345L, 349N, 352S, 356R, 404G, 407S, 408G, 411I, 415P, 416S, 419G, 430R, 431L, 434M, 435F, 438N, 439A, 442S
CDD
cd06174 (MFS)

Protein sequence

>MCA_06052_1
MSSLSTQNQTNIKKPNIGEKDQDQFPEGGRGWLVVAGCFVILGQTYGLINAYGQYQIEYEKLYPGTKSEILALIGSLQPF
MVNLSSVVAVPLIKAIGPRFTVLIAMVIISFGYMMLSLAKEIWQVFLAQGIVIGVGLGLCCFVGFSIPQQWFKKRRALAV
GIVASGSSLGGTVWPIAVSHLEKQVGMPWTNRIIGFIYLPLLAFAAIAVKARVLPSSSSSQNNQDIESKQEKESHHSHHN
LANLPDDIIANELAEEMGLEESGSIKTSDKSNATKKLQQELPRKKYLGIFHSHFLLDWTVSKDWTFQVYLFSTFMAFLGL
FLPLFYLPTYCQRIGASPNIYDYILTILNAASIIGRIVPGYIGDKIGRLNSLIPFVLFSGISILVFWLPTNTVALAIVFA
VAYGITSGSVISLYPSVIGQLFGIEGLPSRLTLMFLANAIPSLIGPLIGGSFLPLEQDVGDRGFYKLMVFSAVSFLVAAA
ALIYLRLSISRKLFVFL

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features