Protein

MCA_05988_1

Length
745 amino acids

Gene name: PRP43A

Description: Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

Browser: contigD:2969223-2971461-

RNA-seq: read pairs 1393, FPKM 23.1, percentile rank 45.3% (100% = highest expression)

Protein function

Annotation:PRP43APre-mRNA-splicing factor ATP-dependent RNA helicase PRP43
KEGG:K12820DHX15 pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15/PRP43 [EC:3.6.4.13]
EGGNOG:0PGYCPRP43factor ATP-dependent RNA helicase
SGD closest match:S000003088PRP43Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43
CGD closest match:CAL0000191988orf19.1687DEAH-box ATP-dependent RNA helicase

Protein alignments

%idAln lengthE-value
MIA_01237_185.27%7060.0MIA_01237_1
A0A0J9XJZ0_GEOCN80.25%7190.0Similar to Saccharomyces cerevisiae YGL120C PRP43 RNA helicase in the DEAH-box family OS=Geotrichum candidum GN=BN980_GECA20s01264g PE=4 SV=1
A0A170R0C5_9ASCO78.12%7040.0DEAH-box ATP-dependent RNA helicase PRP43 OS=Sugiyamaella lignohabitans GN=PRP43 PE=4 SV=1
A0A1E3PM98_9ASCO75.69%7240.0p-loop containing nucleoside triphosphate hydrolase protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82858 PE=4 SV=1
Q6CEH2_YARLI76.16%7090.0YALI0B15642p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B15642g PE=4 SV=1
UniRef50_A0A163D3L873.06%7350.0ATP binding n=2 Tax=Dothideomycetes TaxID=147541 RepID=A0A163D3L8_DIDRA
A0A060T8Y1_BLAAD74.36%7020.0ARAD1D06644p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D06644g PE=4 SV=1
Q5AJA5_CANAL72.63%7160.0DEAH-box ATP-dependent RNA helicase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.1687 PE=4 SV=1
PRP43_YEAST70.60%7380.0Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRP43 PE=1 SV=1
A0A1E4TFZ5_9ASCO47.93%6530.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_108233 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0277

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 745

Detailed signature matches

  1. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  2. Domain IPR014001
    Helicase superfamily 1/2, ATP-binding domain
    1. PS51192 (HELICASE_A...)
    2. SM00487 (ultradead3)
  3. Domain IPR011545
    DEAD/DEAH box helicase domain
    1. PF00270 (DEAD)
  4. Domain IPR001650
    Helicase, C-terminal
    1. PS51194 (HELICASE_CTER)
    2. SM00490 (helicmild6)
    3. PF00271 (Helicase_C)
  5. Domain IPR007502
    Helicase-associated domain
    1. SM00847 (ha2_5)
    2. PF04408 (HA2)
  6. Domain IPR011709
    Domain of unknown function DUF1605
    1. PF07717 (OB_NTP_bind)
  7. SITE IPR002464
    DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
    1. PS00690 (DEAH_ATP_H...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. cd00046 (DEXDc)
  3. cd00079 (HELICc)
  4. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. putative Mg++ bind...
  3. nucleotide binding...
  4. ATP-binding site c...

Protein sequence

>MCA_05988_1
MSDSDDSHVSKKVKTSIDSKSNENGAESTDELPILYPLSEQLKGFKRRKTTAEQAEKVEDGKINPFNDQPFSDKYFKILK
TRRDLPVHAQRQEFLDIYHSTQIMVFVGETGSGKTTQIPQFVAYDDLPQAEGKMVACTQPRRVAAMSVAQRVADEMDVKL
GEQVGYTIRFEDCTGPNTLLKYMTDGMLLREAMSDPELSRYSCVILDEAHERTLATDILMGLIKTIADRRKDLKIIVMSA
TLDAEKFQTYFNNAPLLAVPGRTFPVEIYYTPEYQRDYLESAIRTVLQIHASEGEGDILLFLTGEEEIEDACRKISLEAD
ELIRDGHAGPLDVYPLYGSLPPAQQQKIFNKAPEPFTPGGLPGRKVVISTNIAETSLTIDGIVYVVDPGFSKQKVYNPRI
RVESLLVSPISKASAQQRAGRAGRTRPGKCFRLYTEESYKKELNDQSYPEILRSNLASTVLELKKLGIDDLVHFDFMDPP
APETMMRALEELNYLGCLDDDGNLMPLGRTASEFPVDPMLAVMCIRSEEFYCSQDILSIAALLSVPNVFVRPNNARKQAD
DMKNVFASANGDHLTMLNVYNAYRSPEAQANPSQWCFDHYLSYRSLKSADNVRQQLARIMERNGIQLITTPLEDPDYESN
IQKAIAAGYFMQVASKPTANSKTYTTIKDNQDVALHPSTTLAADTKWVVYNEFVLTTKNYIRTVTAVQPEWLLQLAPKYY
DLKTFKESDAKMSLARAEQRLKRRQ

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003676 nucleic acid binding
GO:0004386 helicase activity
GO:0005524 ATP binding

Cellular Component

None predicted.