Protein

MCA_05895_1

Length
1,080 amino acids

Gene name: FPK1

Description: Serine/threonine protein kinase Fpk1; in S. cerevisiae phosphorylates several aminophospholipid translocase family members, regulating phospholipid translocation and membrane asymmetry

Browser: contigD:2671323-2674566+

RNA-seq: read pairs 1043, FPKM 11.9, percentile rank 29.0% (100% = highest expression)

Protein function

Annotation:FPK1Serine/threonine protein kinase Fpk1; in S. cerevisiae phosphorylates several aminophospholipid translocase family members, regulating phospholipid translocation and membrane asymmetry
KEGG:K08286E2.7.11.- protein-serine/threonine kinase [EC:2.7.11.-]
EGGNOG:0PGX9FG04382.1serine threonine-protein kinase
SGD closest match:S000005330FPK1Flippase kinase 1
CGD closest match:CAL0000190319orf19.223Serine/threonine protein kinase

Protein alignments

%idAln lengthE-value
MIA_04536_160.41%6390.0MIA_04536_1
A0A0J9X8B7_GEOCN57.57%6410.0Similar to Saccharomyces cerevisiae YCR091W KIN82 Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases OS=Geotrichum candidum GN=BN980_GECA05s01682g PE=4 SV=1
Q6CHV0_YARLI72.73%3960.0YALI0A04697p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A04697g PE=4 SV=1
UniRef50_Q6CHV072.73%3960.0YALI0A04697p n=125 Tax=Fungi TaxID=4751 RepID=Q6CHV0_YARLI
A0A167BX45_9ASCO71.95%4100.0Serine/threonine protein kinase FPK1 OS=Sugiyamaella lignohabitans GN=FPK1 PE=4 SV=1
A0A060TC36_BLAAD69.10%4110.0ARAD1D39182p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D39182g PE=4 SV=1
A0A1E3PN56_9ASCO68.82%3564e-166Pkinase-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82210 PE=4 SV=1
A0A1D8PI94_CANAL65.59%4013e-168Serine/threonine protein kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.223 PE=4 SV=1
A0A1E4TAD1_9ASCO74.85%3263e-167Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_32224 PE=4 SV=1
FPK1_YEAST61.22%4107e-159Flippase kinase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FPK1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.5627
Predicted cleavage: 119

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 700 800 900 1000 1080

Detailed signature matches

  1. Domain IPR011009
    Protein kinase-like domain
    1. SSF56112 (Protein k...)
  2. Domain IPR000719
    Protein kinase domain
    1. PS50011 (PROTEIN_KI...)
    2. SM00220 (serkin_6)
    3. PF00069 (Pkinase)
  3. SITE IPR008271
    Serine/threonine-protein kinase, active site
    1. PS00108 (PROTEIN_KI...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.51...
  2. G3DSA:3.30.20...
  3. cd05574 (STKc_photo...)
  4. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. active site cd05574
  3. substrate binding ...
  4. activation loop (A...

Protein sequence

>MCA_05895_1
MGSAPATPILQDLSLSSNSTSQSFYSNPNVLGSNSNIPTAFSTRPTALLTPQQQFQASRKQNRSHADLTKVSATVHSIPI
SGSANTNTNGSSTYTSPSPSPGPYSTSPASNGSTVLRTAGGPLHSSNNALDNGEQLFDSPSSPSGQQQQQHTYQYPTKQS
INGNILNGNSSSHTSIIPQKIKSFFKISLSSSSSPSNPPTYQNDPFIPAGATGTNNFTTANPNYSGYASSTSTATTPNGA
FGTTPTSGYFSRRGSAVNVSSSAPLSPILNPIPQSEIPTDLDQSPPILIHHDRQGSKSSTEGSGSPGFDATSAQPSSIPI
PVPVSHPTTKTQASSSFTSKTRRLLRLRSPSSPAVINEPLLREVTGSSTPPIPAIAVDPLLADSSSTGDNHSSIFSSHNN
NSNKISPALKQNNDQHPHSFSPGTLFHAMSFQHNNASSKADSSSSIQPQEEQEAQSPSSKNEPIAQPSSPSNEGANLQPP
KGLFSRQIRRVASAPNGIKGIISGSNTSTNTSTTSNASSNTPSTVPSPTCQATSNDASAEALAGISEVDITEQDLKAPDT
PPSNAKSTQDGNNRREHTKSNSSASHTKQKSSGFNFPNGLSESVNALQPPPPIGGGGKSRSRANSKSYNRNYSSSSIKVR
EVEVGPGSFDKIKLLGQGDVGKVYLVREKKTNKFYAMKVLNKQEMIKRNKIKRALAEQEILASSNHPFIVTLHHSFQSED
YLYLCMEYCMGGEFFRALQARERKSICENDARFYAAEVTAALEYLHLMGFIYRDLKPENILLHQSGHIMLSDFDLSKQSD
STGAPTIVNSGKSGSSSSNMPAIDTKACIANFRTNSFVGTEEYIAPEVIKGNGHTSAVDWWTLGILLYEMLYGVTPFKGR
TRNATFANVLKQEVIFLDGSEYQSLSSSCKNIIRKLLIKDENKRLGSKAGASDVKAHPFFKNTQWALLRNQTPPIIPIPS
KTSKAHPMYKSGDNKSVDFTNGDKEHLLDNPKNHHNGSNGEGSSSGSSRVMREDDPFLNFNSVTLHHEGIDNDDEYGSDY
GDNFNFGLGGIEYSMSSSSPGTRHNSSTGASNHKHFVLKR

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0005524 ATP binding

Cellular Component

None predicted.