Protein

MCA_05871_1

Length
571 amino acids

Gene name: SFH5

Description: Phosphatidylinositol transfer protein SFH5

Browser: contigD:2598624-2600340+

RNA-seq: read pairs 7568, FPKM 163.5, percentile rank 85.8% (100% = highest expression)

Protein function

Annotation:SFH5Phosphatidylinositol transfer protein SFH5
EGGNOG:0PM5WSFH5Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding transfer activity in the absence of detectable PtdCho-binding transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane (By similarity)
SGD closest match:S000003681SFH5Phosphatidylinositol transfer protein SFH5
CGD closest match:CAL0000192835SFH5Phosphatidylinositol transfer protein SFH5

Protein alignments

%idAln lengthE-value
MIA_03010_171.01%1693e-81MIA_03010_1
A0A0J9XJR6_GEOCN55.91%1865e-62Similar to Saccharomyces cerevisiae YJL145W SFH5 Non-classical phosphatidylinositol transfer protein (PITP) OS=Geotrichum candidum GN=BN980_GECA22s01275g PE=4 SV=1
UniRef50_A0A0J9XJR655.91%1861e-58Similar to Saccharomyces cerevisiae YJL145W SFH5 Non-classical phosphatidylinositol transfer protein (PITP) n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XJR6_GEOCN
A0A167EJS3_9ASCO58.18%1651e-57Sfh5p OS=Sugiyamaella lignohabitans GN=SFH5 PE=4 SV=1
A0A060T1L6_BLAAD45.97%2112e-54ARAD1C21516p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C21516g PE=4 SV=1
A0A1E3PKH5_9ASCO58.44%1541e-50CRAL/TRIO domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83417 PE=4 SV=1
SFH5_YARLI56.67%1507e-50Phosphatidylinositol transfer protein SFH5 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=SFH5 PE=3 SV=1
SFH5_YEAST53.72%1211e-39Phosphatidylinositol transfer protein SFH5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SFH5 PE=1 SV=1
SFH5_CANAL38.54%1921e-33Phosphatidylinositol transfer protein SFH5 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SFH5 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0268

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 100 200 300 400 500 571

Detailed signature matches

  1. Domain IPR011074
    CRAL/TRIO, N-terminal domain
    1. SSF46938 (CRAL/TRIO...)
  2. Domain IPR001251
    CRAL-TRIO lipid binding domain
    1. PS50191 (CRAL_TRIO)
    2. SM00516 (sec14_4)
    3. cd00170 (SEC14)
    4. PF00650 (CRAL_TRIO)
    5. G3DSA:3.40.52...
    6. SSF52087 (CRAL/TRIO...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:1.10.8.20
  3. mobidb-lite (disord...)

Residue annotation

  1. phospholipid bindi...
  2. salt bridge cd00170

Protein sequence

>MCA_05871_1
MSDAQNIQLNKLLAALPAIFETVGYSELYGYDFATIESIPNGTIIRDCILTKFLVANKYNVEHATLQLQNTLKWRKSFNP
LSAAFLETHSTELNKLGIITSVPIDKNGSTNGGTATSTEEFSKLAEEEEKKKQADAKAALEKEKAAKGDDASSISSSSSS
SSSSSSEEEKKPAPEAEDDDLGLAGPSTSKETPKEEPVTNTTSATEQTTTAQTTTQPTTTTEKEQSTDYLTVTWNLYGQV
ENREKLFKNLDEFLRWRVGLMERGIANLDFTKRETSYMAQVHDYKNVSFFRLDSSTKEASKHTIEIFTKYYPEFLNYKYF
VNVPKIMYWMFIFTKKFLPRATVDKFRVVSNGKDFALQTGNLWVPADYGGEAESLQALELKDSKPRFDDLVSKYDPVKAK
EIAREQVAPVAVPLAPESKGESVAVAATDNKDLPNDVVVAPAPAPTETVQHSEAGINDNAPPTTAKAVPTTTADASTTDA
ATTAQNVTEQEPKTAEPPQQPATDIHLNTDTPVLKEGTTTVLEATSTSTLSNEPPQPGAVPTEPTPTTTSAVTTESSEPA
APQPGAVPKSD

GO term prediction

Biological Process

None predicted.

Molecular Function

None predicted.

Cellular Component

None predicted.