Protein

MCA_05847_1

Length
586 amino acids

Browser: contigD:2527826-2529587+

RNA-seq: read pairs 1025, FPKM 21.6, percentile rank 43.3% (100% = highest expression)

Protein function

KEGG:K12261HACL1 2-hydroxyacyl-CoA lyase 1 [EC:4.1.-.-]
EGGNOG:0PHRM2-hydroxyacyl-CoA lyase
SGD closest match:S000000746YEL020CPutative 2-hydroxyacyl-CoA lyase
CGD closest match:CAL0000198378ILV2Acetolactate synthase

Protein alignments

%idAln lengthE-value
MIA_06352_171.26%5880.0MIA_06352_1
A0A0J9XDJ5_GEOCN67.12%5900.0Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA11s01077g PE=3 SV=1
A0A167CPH2_9ASCO63.57%5820.0Putative indolepyruvate decarboxylase family protein OS=Sugiyamaella lignohabitans GN=AWJ20_180 PE=3 SV=1
A0A060T4T0_BLAAD61.45%5810.0ARAD1B05632p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B05632g PE=3 SV=1
Q6C6Q2_YARLI57.09%5780.0YALI0E07315p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E07315g PE=3 SV=1
UniRef50_A6QZJ847.58%6202e-171Uncharacterized protein n=34 Tax=Eurotiomycetes TaxID=147545 RepID=A6QZJ8_AJECN
YEC0_YEAST44.89%5773e-138Putative 2-hydroxyacyl-CoA lyase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YEL020C PE=1 SV=1
A0A1E4TBX7_9ASCO46.82%5981e-134Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_27702 PE=3 SV=1
A0A1E3PEI5_9ASCO51.01%3453e-106Thiamin diphosphate-binding protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83921 PE=4 SV=1
A0A1D8PJF9_CANAL26.95%5903e-34Acetolactate synthase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ILV2 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1700

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 586

Detailed signature matches

  1. Domain IPR029061
    Thiamin diphosphate-binding fold
    1. SSF52518 (Thiamin d...)
  2. Domain IPR012001
    Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain
    1. PF02776 (TPP_enzyme_N)
  3. Domain IPR029035
    DHS-like NAD/FAD-binding domain
    1. SSF52467 (DHS-like ...)
    2. G3DSA:3.40.50...
  4. Domain IPR012000
    Thiamine pyrophosphate enzyme, central domain
    1. PF00205 (TPP_enzyme_M)
  5. Domain IPR011766
    Thiamine pyrophosphate enzyme, C-terminal TPP-binding
    1. PF02775 (TPP_enzyme_C)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. cd02004 (TPP_BZL_OC...)
  3. cd07035 (TPP_PYR_PO...)

Residue annotation

  1. PYR/PP interface c...
  2. TPP binding site c...
  3. dimer interface cd...
  4. TPP-binding site ...
  5. dimer interface cd...

Protein sequence

>MCA_05847_1
MSKQVSGAELMADSLAQLGIKHIFGIVGIPVIEVADACIARGIKFISFRNEQAASYAASIYGYLTGLPGVCLVVGGPGVL
HAAAGVGNAMANHLPLLLLAGSSETHLVEKGAFQELDQVSYLRPLTKMAARPSSLQTFPALLEKAYRVSYFGRPGATYID
LPGDLIKDSISVEDVKEIRTSHHIKPPGPAPKASGDPEKIAQAVSLLSQAKTPLIIIGKGAAYGQAEESIRNFNDIVQFP
FLPTPMGKGVIPDDSPLNVSACRSTALKNADVILLLGARLNWILHYGESPKFRPDAQIIQVDLAADELGNNTGCPDLGIV
GDIGLVVDALSQAFKKTSASGAYFKPNQKLTKLPIPEWETVKARNIAKAQKADDDTSYPVKYQPVYRVIREVIASKVKNK
LDKVVYVSEGANTMDISRSSFPLNHPRARLDAGTNATMGLGLGYAIAAKAALGSEALVVAIEGDSAFGFSGIEIETAVRS
KLPIIVVVMNNSGVYHGVDPKRYEEEAPLPSTALQLETKYHLFADSLGAKGYLVKTLEEVEDAFSKAIDAYYSKGESSLL
NIIIDVAKDKKLEFGWMASTKKKAKL

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0030976 thiamine pyrophosphate binding

Cellular Component

None predicted.