Protein

MCA_05804_1

Length
734 amino acids

Gene name: MCM5

Description: DNA replication licensing factor MCM5 ; Component of the Mcm2-7 hexameric helicase complex

Browser: contigD:2383761-2385966-

RNA-seq: read pairs 666, FPKM 11.2, percentile rank 27.8% (100% = highest expression)

Protein function

Annotation:MCM5DNA replication licensing factor MCM5 ; Component of the Mcm2-7 hexameric helicase complex
KEGG:K02209MCM5 DNA replication licensing factor MCM5 [EC:3.6.4.12]
EGGNOG:0PGACMCM5DNA replication licensing factor mcm5
SGD closest match:S000004264MCM5Minichromosome maintenance protein 5
CGD closest match:CAL0000182764CDC46DNA helicase

Protein alignments

%idAln lengthE-value
MIA_00775_181.12%7470.0MIA_00775_1
A0A0J9X9U4_GEOCN72.96%7360.0DNA helicase OS=Geotrichum candidum GN=BN980_GECA06s02606g PE=3 SV=1
A0A167D2B2_9ASCO69.01%7390.0DNA helicase OS=Sugiyamaella lignohabitans GN=MCM5 PE=3 SV=1
A0A1E3PCR8_9ASCO67.44%7370.0DNA helicase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_53502 PE=3 SV=1
A0A060T7I9_BLAAD66.71%7360.0DNA helicase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C28512g PE=3 SV=1
UniRef50_A0A0E9NII066.34%7160.0DNA helicase n=2 Tax=Saitoella complicata NRRL Y-17804 TaxID=698492 RepID=A0A0E9NII0_9ASCO
Q59P49_CANAL63.58%7440.0DNA helicase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CDC46 PE=3 SV=1
MCM5_YEAST59.77%7780.0Minichromosome maintenance protein 5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MCM5 PE=1 SV=1
Q6CI63_YARLI57.14%7490.0DNA helicase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A01353g PE=3 SV=1
A0A1E4TAW6_9ASCO58.13%7380.0DNA helicase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_130564 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0843

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 734

Detailed signature matches

  1. Family IPR031327
    Mini-chromosome maintenance protein
    1. SM00350 (mcm)
  2. Family IPR008048
    DNA replication licensing factor Mcm
    1. PR01661 (MCMPROTEIN5)
  3. Domain IPR012340
    Nucleic acid-binding, OB-fold
    1. SSF50249 (Nucleic a...)
  4. Domain IPR027925
    MCM N-terminal domain
    1. PF14551 (MCM_N)
  5. Domain IPR033762
    MCM OB domain
    1. PF17207 (MCM_OB)
  6. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  7. Domain IPR001208
    MCM domain
    1. PS50051 (MCM_2)
    2. PR01657 (MCMFAMILY)
    3. PF00493 (MCM)
  8. SITE IPR018525
    Mini-chromosome maintenance, conserved site
    1. PS00847 (MCM_1)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:2.40.50...
  3. G3DSA:3.30.16...
  4. G3DSA:3.40.50...
  5. cd00009 (AAA)

Residue annotation

  1. Walker A motif cd0...
  2. ATP binding site c...
  3. Walker B motif cd0...
  4. arginine finger cd...

Protein sequence

>MCA_05804_1
MSFDRGQITTTSVLPGDSQRDNSFSEIYAIFRSFILEFWLNNTFIYRDQLRENILVKNYSLTVDIAHIISFNEDLGQRIS
EEPSEILPIFEKVIREVAQRIVYPSIVAEAERNSSSTDAAIEAKEAIASIPLCQIILKSDANPISIRELSANYISKLVRI
PGIVIGASTLSSKAISLQLVCRNCHHLHRIEVGSGFSGISLPKTCLGDHDGSRQKCPPNPYVVWHEKSTFIDQQTLKLQE
APDMVPVGEMPRHILLSVDRRLCNTVTPGTRCTVVGIYSIFQRKQPKGTPSAVAVRNPYLRVVGIQQDAGHDLMRNMVFT
EEEEEEFINLSKNPDLYEIFARSIAPSIYGSNDVKKAIACLLMGGSKKILPDGMRLRGDINVLLLGDPGTAKSQLLKFVE
KVSPIAIYTSGKGSSAAGLTASVHRDAQTRDFYLEGGAMVLADGGVVCIDEFDKMRDEDRVAIHEAMEQQTISIAKAGIT
TVLNSRTSVLAAANPIFGRYDELKSPGENIDFQTTILSRFDMIFIIKDEHNEQRDMEIAQHVMSIHMNRNTSEAVGEIPI
EKMKRYIAYCKAKCAPRLTPEAAQALSSEFVDIRQNVQQQEQEANERSSIPITVRQLEAIIRITESLAKLQLSPVATLEH
VKEAMRLFQCSTMSAVESGAGTRQELVHDVNKIEGELKRRLPIGWSTSYQRLLNEFVNSGRYQQNALDRALMILERRDSI
QFRHQRKQIFRSGA

GO term prediction

Biological Process

GO:0006260 DNA replication
GO:0006270 DNA replication initiation

Molecular Function

GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003682 chromatin binding
GO:0003688 DNA replication origin binding
GO:0005524 ATP binding

Cellular Component

GO:0005634 nucleus
GO:0042555 MCM complex