MCA_05723_1

Protein

Length

273 amino acids

Gene name: TOA1

Description: Transcription initiation factor IIA large subunit

Browser: contigD:2149578-2150400-

RNA-seq: read pairs 2146, FPKM 96.8, percentile rank 78.1% (100% = highest expression)

Protein function

Annotation:		TOA1	Transcription initiation factor IIA large subunit
KEGG:	K03122	TFIIA1	transcription initiation factor TFIIA large subunit
EGGNOG:	0PM7H	TOA1	transcription factor TFIIA complex subunit Toa1
SGD closest match:	S000005720	TOA1	Transcription initiation factor IIA large subunit
CGD closest match:	CAL0000181129	orf19.2682	Transcription initiation factor IIA large subunit

Protein alignments

	%id	Aln length	E-value
MIA_05079_1	53.61%	166	6e-26	MIA_05079_1
A0A060T7R6_BLAAD	64.62%	65	4e-21	ARAD1C24112p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C24112g PE=4 SV=1
UniRef50_A0A060T7R6	64.62%	65	9e-18	ARAD1C24112p n=1 Tax=Blastobotrys adeninivorans TaxID=409370 RepID=A0A060T7R6_BLAAD
A0A0J9X6X9_GEOCN	68.42%	57	8e-21	Similar to Saccharomyces cerevisiae YOR194C TOA1 TFIIA large subunit OS=Geotrichum candidum GN=BN980_GECA04s01671g PE=4 SV=1
A0A161HKR6_9ASCO	66.67%	57	2e-20	Toa1p OS=Sugiyamaella lignohabitans GN=TOA1 PE=4 SV=1
A0A1E3PM45_9ASCO	80.49%	41	1e-19	Transcription factor IIA, alpha/beta subunit OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45958 PE=4 SV=1
Q6CCD2_YARLI	57.14%	63	2e-18	YALI0C10472p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C10472g PE=4 SV=1
A0A1E4TKY4_9ASCO	57.89%	57	6e-18	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30588 PE=4 SV=1
Q5AFC5_CANAL	73.17%	41	1e-15	Transcription initiation factor IIA large subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.2682 PE=4 SV=1
TOA1_YEAST	50.88%	57	4e-14	Transcription initiation factor IIA large subunit OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TOA1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1079

Protein family membership

Transcription factor IIA, alpha/beta subunit (IPR004855)

Domains and repeats

Domain
2 - 46
Transcription factor IIA, helical (IPR009083)
192 - 273
Transcription factor IIA, beta-barrel (IPR009088)

1 50 100 150 200 273

Detailed signature matches

IPR004855

Transcription factor IIA, alpha/beta subunit
1. SM01371 (TFIIA_2)
  
  8 - 273
  
  SMART
  SM01371 (TFIIA_2)
2. cd07976 (TFIIA_alph...)
  
  6 - 273
  
  CDD
  cd07976 (TFIIA_alpha_beta_like)
3. PF03153 (TFIIA)
  
  108 - 273
  
  Pfam
  PF03153 (TFIIA)
  
  9 - 67
  
  Pfam
  PF03153 (TFIIA)
IPR009083

Transcription factor IIA, helical
1. SSF47396 (Transcrip...)
  
  2 - 46
  
  SUPERFAMILY
  SSF47396 (Transcription factor IIA (TFIIA), alpha-helical domain)
IPR009088

Transcription factor IIA, beta-barrel
1. SSF50784 (Transcrip...)
  
  218 - 273
  
  SUPERFAMILY
  SSF50784 (Transcription factor IIA (TFIIA), beta-barrel domain)
2. G3DSA:2.30.18.10
  
  192 - 273
  
  GENE3D
  G3DSA:2.30.18.10 (G3DSA:2.30.18.10)

no IPR

Unintegrated signatures

G3DSA:1.10.28...

5 - 51

GENE3D
G3DSA:1.10.287.100 (G3DSA:1.10.287.100)
mobidb-lite (disord...)

55 - 88

MobiDB Lite
mobidb-lite (disorder_prediction)

187 - 227

MobiDB Lite
mobidb-lite (disorder_prediction)

128 - 153

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

TFIIA subunit inte...

8E

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

9L

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

10Y

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

12D

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

13I

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

16G

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

17V

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

20E

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

21I

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

25F

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

30V

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

34T

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

37E

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

38L

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

41I

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

42W

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

45K

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

46L

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

49L

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

51V

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

227E

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

228N

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

231M

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

232M

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

233L

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

234C

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

235L

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

236Y

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

237D

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

239V

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

246W

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

248Y

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

252D

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

253G

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

254V

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

255A

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

256N

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

257I

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

258N

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

261D

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

262Y

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

263V

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

264F

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

265N

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

266K

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

267S

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

268T

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

269G

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

270E

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

271S

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

272E

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

273W

TFIIA subunit interface
8E, 9L, 10Y, 12D, 13I, 16G, 17V, 20E, 21I, 25F, 30V, 34T, 37E, 38L, 41I, 42W, 45K, 46L, 49L, 51V, 227E, 228N, 231M, 232M, 233L, 234C, 235L, 236Y, 237D, 239V, 246W, 248Y, 252D, 253G, 254V, 255A, 256N, 257I, 258N, 261D, 262Y, 263V, 264F, 265N, 266K, 267S, 268T, 269G, 270E, 271S, 272E, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)
DNA binding site c...

238K

DNA binding site
238K, 241R, 243K
CDD
cd07976 (TFIIA_alpha_beta_like)

241R

DNA binding site
238K, 241R, 243K
CDD
cd07976 (TFIIA_alpha_beta_like)

243K

DNA binding site
238K, 241R, 243K
CDD
cd07976 (TFIIA_alpha_beta_like)
TBP interaction si...

241R

TBP interaction site
241R, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

273W

TBP interaction site
241R, 273W
CDD
cd07976 (TFIIA_alpha_beta_like)

Protein sequence

>MCA_05723_1
MSNKIVGELYQDIIEGVIREIRLDFEDSGVDETTLQELKQIWQQKLSSLAVADFPWDAPQSPQPTSGLLSGGDLGSNGNA
SNSNNVSANTNGISAGSAPAQVVGGLVLPGGGQIAQTDGPLAHLLTTSSSIKNTTKENDTDSDTSKTPSRIEADNILQEK
LLKSSQQQSDIEIDIPPHLLRRIKRQQADGALGDDDDEDENDSDGINSDLDDPDDNQDSGSDDDDMENGMMMLCLYDKVQ
RVKTKWKYILKDGVANINGKDYVFNKSTGESEW

GO term prediction

Biological Process

GO:0006367 transcription initiation from RNA polymerase II promoter

Molecular Function

None predicted.

Cellular Component

GO:0005672 transcription factor TFIIA complex

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Entry type

Status

Per-residue features