Protein

MCA_05707_1

Length
679 amino acids

Gene name: TKL1

Description: Transketolase 1

Browser: contigD:2088475-2091251+

RNA-seq: read pairs 28375, FPKM 515.6, percentile rank 94.3% (100% = highest expression)

Protein function

Annotation:TKL1Transketolase 1
KEGG:K00615E2.2.1.1 transketolase [EC:2.2.1.1]
EGGNOG:0PGGVTKL1Transketolase
SGD closest match:S000006278TKL1Transketolase 1
CGD closest match:CAL0000174068TKL1Transketolase

Protein alignments

%idAln lengthE-value
MIA_02135_183.24%6800.0MIA_02135_1
A0A0J9XLB1_GEOCN77.17%6790.0Transketolase OS=Geotrichum candidum GN=BN980_GECA27s00934g PE=3 SV=1
A0A1E3PIT3_9ASCO69.81%6790.0Transketolase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83300 PE=3 SV=1
A0A060TFF3_BLAAD69.13%6770.0Transketolase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D22748g PE=3 SV=1
Q6C6T4_YARLI67.16%6790.0Transketolase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E06479g PE=3 SV=1
UniRef50_Q6C6T467.16%6790.0Transketolase n=150 Tax=Dikarya TaxID=451864 RepID=Q6C6T4_YARLI
A0A1E4TF70_9ASCO67.40%6810.0Transketolase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_25657 PE=3 SV=1
A0A167FJV4_9ASCO68.26%6490.0Transketolase TKL1 OS=Sugiyamaella lignohabitans GN=TKL1 PE=4 SV=1
TKT1_YEAST64.80%6790.0Transketolase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TKL1 PE=1 SV=4
Q5A750_CANAL64.64%6760.0Transketolase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TKL1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.3370

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 679

Detailed signature matches

  1. Family IPR005478
    Transketolase, bacterial-like
    1. TIGR00232
  2. Domain IPR029061
    Thiamin diphosphate-binding fold
    1. SSF52518 (Thiamin d...)
  3. Domain IPR005474
    Transketolase, N-terminal
    1. PF00456 (Transketol...)
    2. PS00801 (TRANSKETOL...)
  4. Domain IPR005475
    Transketolase-like, pyrimidine-binding domain
    1. PF02779 (Transket_pyr)
    2. SM00861 (Transket_p...)
  5. Domain IPR009014
    Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II
    1. G3DSA:3.40.50...
    2. SSF52922 (TK C-term...)
  6. Domain IPR033248
    Transketolase, C-terminal domain
    1. PF02780 (Transketol...)
  7. SITE IPR020826
    Transketolase binding site
    1. PS00802 (TRANSKETOL...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. cd02012 (TPP_TK)
  3. cd07033 (TPP_PYR_DX...)

Residue annotation

  1. TPP-binding site c...
  2. dimer interface cd...
  3. PYR/PP interface c...
  4. dimer interface cd...
  5. TPP binding site c...

Protein sequence

>MCA_05707_1
MTFSEIDTKAINTIRVLSIDGVAAANSGHPGAPMGLAPTAHVLFNNFLRFNPKNPDWLNRDRFVLSNGHGCMLQYSLLHL
FGYDYSIDDLKHFRKLNSKTPGHPEAELPGIEVTTGPLGQGISNAVGLAIGQKHFGARFNKPGYELFNGYTYAIAGDGCL
MEGVASEAASLAGHLQLGNLIVFYDDNKITIDGSTNVAFTEDVLARFQAYGWHTLEVADGNNDLEGIYNAVVEAKKVTDK
PTLIKVTTIIGFGSKLQGTHTVHGAPLKADDIEAVKIKWGFDPKKSFDVSPEVYEYYAKTVSKNQAEESEWNKLVESYVS
KYPEEGADLKRRLNNELPAGWEKALPTYKPTDAPVASRKLSEIVLSSIFDEVPELIGGSADLTGSNLTKTKESIDFQPPS
TNLGTYAGRYIRYGVREHAMGAILNGLAAHGGIIPYGGTFLNFVSYGVGALRLSALSQARVIWVGTHDSIGLGEDGPTHQ
PIETLAHLRAIPNLQVWRPADGNETSAAYYQSIISKKTPSVIALTRQNLPQLEGSSIEKASKGGYLIHEASDKPDVLIVS
TGSEVSLSIDAAKLLGEKGLKVNVVSLPDWYTFGKQSDDYRLSVIPDGVPVLSVEVMSTVGWASYAHESFGINRFGASGP
YKDVYKFFGFTPEGIAEKAQKVAEFYKGKSLSSPLRKAL

GO term prediction

Biological Process

GO:0008152 metabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0004802 transketolase activity

Cellular Component

None predicted.