Protein

MCA_05701_1

Length
416 amino acids

Gene name: POT1

Description: 3-ketoacyl-CoA thiolase, peroxisomal

Browser: contigD:2075148-2076399-

RNA-seq: read pairs 7266, FPKM 215.3, percentile rank 88.9% (100% = highest expression)

Protein function

Annotation:POT13-ketoacyl-CoA thiolase, peroxisomal
KEGG:K07513ACAA1 acetyl-CoA acyltransferase 1 [EC:2.3.1.16]
EGGNOG:0PFKZPOT13-keto-acyl-CoA thiolase
SGD closest match:S000001422POT13-ketoacyl-CoA thiolase, peroxisomal
CGD closest match:CAL0000176675POT1Acetyl-CoA C-acyltransferase

Protein alignments

%idAln lengthE-value
A0A0J9XDV0_GEOCN74.28%4160.0Similar to Saccharomyces cerevisiae YIL160C POT1 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids OS=Geotrichum candidum GN=BN980_GECA11s01451g PE=3 SV=1
MIA_02130_176.44%4160.0MIA_02130_1
THIK_YARLI73.25%4150.03-ketoacyl-CoA thiolase, peroxisomal OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=POT1 PE=3 SV=1
A0A167F2S7_9ASCO69.21%4190.0Acetyl-CoA C-acyltransferase OS=Sugiyamaella lignohabitans GN=POT1 PE=3 SV=1
A0A1E3PSS7_9ASCO67.47%4150.0Peroxisomal 3-oxoacyl-CoA thiolase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_48961 PE=3 SV=1
A0A1E4THP9_9ASCO66.02%4150.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_31916 PE=3 SV=1
A0A060T969_BLAAD66.91%4172e-178ARAD1D09306p OS=Blastobotrys adeninivorans GN=AKAT1 PE=3 SV=1
A0A1D8PRL6_CANAL58.41%4165e-153Acetyl-CoA C-acyltransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=POT1 PE=3 SV=1
UniRef50_A0A068RR0758.31%4152e-1493-ketoacyl-thiolase n=4 Tax=Mucorales TaxID=4827 RepID=A0A068RR07_9FUNG
THIK_YEAST56.34%4261e-1463-ketoacyl-CoA thiolase, peroxisomal OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=POT1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.3307

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 416

Detailed signature matches

  1. Family IPR002155
    Thiolase
    1. TIGR01930
    2. cd00751 (thiolase)
    3. PIRSF000429 (Ac-CoA...)
  2. Domain IPR016039
    Thiolase-like
    1. SSF53901 (Thiolase-...)
    2. G3DSA:3.40.47.10
  3. Domain IPR020616
    Thiolase, N-terminal
    1. PF00108 (Thiolase_N)
  4. Domain IPR020617
    Thiolase, C-terminal
    1. PF02803 (Thiolase_C)
  5. SITE IPR020615
    Thiolase, acyl-enzyme intermediate active site
    1. PS00098 (THIOLASE_1)
  6. SITE IPR020613
    Thiolase, conserved site
    1. PS00737 (THIOLASE_2)
  7. SITE IPR020610
    Thiolase, active site
    1. PS00099 (THIOLASE_3)
Unintegrated signatures no IPR
Unintegrated signatures
  1. mobidb-lite (disord...)

Residue annotation

  1. dimer interface cd...
  2. active site cd00751

Protein sequence

>MCA_05701_1
MNRLNAISNQLSPNTTSSSKDSLFEKHPDDVVIVAAYRTAHTKGGKGLFKDTSSADLLAGLVEGLLKKTGIDPKIVEEFA
VGNVLNAGAGATEHRAAGLAAGLPYTTPFVAINRQCSSGLMAVNDIALKIRAGQISVGIGAGVESMSNNYGPKSASPFSE
KLLKNAEAAKCQIPMGITSENVASKYNITREAQDKFAANSYKKAAEAQAKGLFKEEILPVATVVVDQEDKEHKVVVDKDD
GIRKGVTAESLSKLKPAFSKTGSTHAGNASQVSDGAGAVLLMRRSVAEKLKLPVLAKFVHCKSVGVPPEIMGVGPAYAIP
ALLKDLGLSPDDVDVYEINEAFASQAIFSIEHVGIPYEKVNPRGGAIAFGHPLGATGARQFATLLNELKNTGKKIGVTSM
CIGTGMGAASLVVSEQ

GO term prediction

Biological Process

GO:0008152 metabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups

Cellular Component

None predicted.