Protein

MCA_05543_1

Length
514 amino acids

Gene name: PYK1

Description: Pyruvate kinase

Browser: contigD:1602978-1604786+

RNA-seq: read pairs 35214, FPKM 844.9, percentile rank 96.1% (100% = highest expression)

Protein function

Annotation:PYK1Pyruvate kinase
KEGG:K00873PK pyruvate kinase [EC:2.7.1.40]
EGGNOG:0PFMRPYK1Pyruvate kinase
SGD closest match:S000000036CDC19Pyruvate kinase 1
CGD closest match:CAL0000192883CDC19Pyruvate kinase

Protein alignments

%idAln lengthE-value
MIA_01710_186.38%5140.0MIA_01710_1
S4SX50_GEOCN83.27%5140.0Pyruvate kinase OS=Geotrichum candidum GN=Cdc19 PE=3 SV=1
A0A1E3PFV9_9ASCO79.73%5130.0Pyruvate kinase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47510 PE=3 SV=1
A0A060TF40_BLAAD78.91%5120.0Pyruvate kinase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D12870g PE=3 SV=1
KPYK_YARLI78.21%5140.0Pyruvate kinase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=PYK1 PE=3 SV=3
UniRef50_P3061478.21%5140.0Pyruvate kinase n=14 Tax=Opisthokonta TaxID=33154 RepID=KPYK_YARLI
KPYK_CANAL78.17%5040.0Pyruvate kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CDC19 PE=1 SV=3
A0A1E4TD64_9ASCO74.12%5140.0Pyruvate kinase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_4277 PE=3 SV=1
A0A167F7G8_9ASCO80.40%4540.0Pyruvate kinase OS=Sugiyamaella lignohabitans GN=CDC19 PE=3 SV=1
KPYK1_YEAST73.95%4990.0Pyruvate kinase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CDC19 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0212

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 450 514

Detailed signature matches

  1. Family IPR001697
    Pyruvate kinase
    1. TIGR01064
    2. cd00288 (Pyruvate_K...)
    3. PR01050 (PYRUVTKNASE)
  2. Domain IPR015813
    Pyruvate/Phosphoenolpyruvate kinase-like domain
    1. SSF51621 (Phosphoen...)
  3. Domain IPR015793
    Pyruvate kinase, barrel
    1. PF00224 (PK)
  4. Domain IPR011037
    Pyruvate kinase-like, insert domain
    1. SSF50800 (PK beta-b...)
  5. Domain IPR015795
    Pyruvate kinase, C-terminal
    1. G3DSA:3.40.13...
    2. SSF52935 (PK C-term...)
    3. PF02887 (PK_C)
  6. SITE IPR018209
    Pyruvate kinase, active site
    1. PS00110 (PYRUVATE_K...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:2.40.33.10
  2. G3DSA:3.20.20.60

Residue annotation

  1. domain interfaces ...
  2. active site cd00288

Protein sequence

>MCA_05543_1
MIFSSDTPATTLQWLTTLDVENLPSRNYRRSSIIGTIGPKTNSVEMITNLRKAGLNIVRMNFSHGSHEYHQSVIDNARKS
EENFSGRPIAIALDTKGPEIRTGTTTDNKDYPVEKNHEMIFTTDDAYATKCDDKIMYIDYKNITKVIEVGRIIYVDDGVL
SFQVLQIKDDKTLLVKALNNGKISSHKGVNLPKTDVDLPALSEKDIADIKFGVKNKVDIIFASFIRTADDVLAIRKVLGE
EGKQVQIISKIESQQGVNNFDEILKVTDGVMVARGDLGIEIPASQVFIVQKQLIAKCNLAGKPVICATQMLESMTYNPRP
TRAEVSDVGNAILDGADCVMLSGETAKGDYPIQAVNMMHETCLIAEKAIAYQPLFNELRSLAPRPTETGETIAISAVSAS
FEQQAKAIIVLSTSGATARLLSKYRPNCPILMVTRNASAARFSHLYRGVYPFIYPKPRAENAADWQRDVEERLKWGIDSA
VELGILSKGDVVVAIQGWTGGLGHTNTLRILEAF

GO term prediction

Biological Process

GO:0006096 glycolytic process

Molecular Function

GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004743 pyruvate kinase activity
GO:0030955 potassium ion binding

Cellular Component

None predicted.