Protein

MCA_05540_1

Length
298 amino acids

Browser: contigD:1589370-1590349-

RNA-seq: read pairs 4504, FPKM 186.1, percentile rank 87.3% (100% = highest expression)

Protein function

KEGG:K00767nadC nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19]
EGGNOG:0PG9RFG09549.1nicotinate-nucleotide pyrophosphorylase
SGD closest match:S000001943BNA6Nicotinate-nucleotide pyrophosphorylase [carboxylating]
CGD closest match:CAL0000188735orf19.5054Nicotinate-nucleotide pyrophosphorylase [carboxylating]

Protein alignments

%idAln lengthE-value
MIA_00904_185.91%2985e-176MIA_00904_1
A0A0J9X9D2_GEOCN75.34%2964e-155Nicotinate-nucleotide pyrophosphorylase [carboxylating] OS=Geotrichum candidum GN=BN980_GECA05s07149g PE=3 SV=1
A0A1E3PNC1_9ASCO70.17%2958e-143Nicotinate-nucleotide pyrophosphorylase [carboxylating] OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_41350 PE=3 SV=1
A0A167D7B8_9ASCO70.99%2935e-139Nicotinate-nucleotide pyrophosphorylase [carboxylating] OS=Sugiyamaella lignohabitans GN=BNA6 PE=3 SV=1
Q6C6R1_YARLI70.45%2912e-139Nicotinate-nucleotide pyrophosphorylase [carboxylating] OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E07073g PE=3 SV=1
NADC_YEAST66.55%2908e-136Nicotinate-nucleotide pyrophosphorylase [carboxylating] OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=BNA6 PE=1 SV=1
UniRef50_P4361966.55%2902e-132Nicotinate-nucleotide pyrophosphorylase [carboxylating] n=195 Tax=Eukaryota TaxID=2759 RepID=NADC_YEAST
A0A060T8P8_BLAAD71.92%2922e-135Nicotinate-nucleotide pyrophosphorylase [carboxylating] OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D08932g PE=3 SV=1
A0A1D8PE45_CANAL61.69%2953e-121Nicotinate-nucleotide pyrophosphorylase [carboxylating] OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.5054 PE=3 SV=1
A0A1E4TGQ7_9ASCO61.56%2943e-120Nicotinate-nucleotide pyrophosphorylase [carboxylating] OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2654 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0772

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 298

Detailed signature matches

  1. Family IPR027277
    Nicotinate-nucleotide pyrophosphorylase/Putative pyrophosphorylase ModD
    1. PIRSF006250 (NadC_ModD)
  2. Family IPR004393
    Nicotinate-nucleotide pyrophosphorylase
    1. TIGR00078
    2. cd01572 (QPRTase)
  3. Domain IPR022412
    Quinolinate phosphoribosyl transferase, N-terminal
    1. PF02749 (QRPTase_N)
    2. G3DSA:3.90.11...
  4. Domain IPR013785
    Aldolase-type TIM barrel
    1. G3DSA:3.20.20.70
  5. Domain IPR002638
    Quinolinate phosphoribosyl transferase, C-terminal
    1. SSF51690 (Nicotinat...)
    2. PF01729 (QRPTase_C)
Unintegrated signatures no IPR
Unintegrated signatures
  1. SSF54675 (Nicotinat...)

Residue annotation

  1. dimerization inter...
  2. active site cd01572

Protein sequence

>MCA_05540_1
MSVGQDFAHALPSQGRWKQDVSRWLAEDVPAFDIGGFVVGDDEKTATLWCKQSGVLSGVPFAQEVFNQVGVTAEWKVKEG
EFIDTSKAEGGKVAVAIVKGPVRKLLLSERTALNLLARASGVATQSREITTLAKEAGYKGVIAGTRKTTPGLRIVEKYSM
VVGGADPHRYDLSSMVMLKDNHVWSTGSITNAVKAARKIAGFSTKIEVEVGSEEEANEAIEAGADVIMLDNFKGSELQAA
ALSIKQKWAGKKQFLLECSGGLTKTNIKEYLTNEIDVYSTSSIHQGVPIIDFSLKINV

GO term prediction

Biological Process

GO:0009435 NAD biosynthetic process
GO:0019363 pyridine nucleotide biosynthetic process

Molecular Function

GO:0003824 catalytic activity
GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity
GO:0016763 transferase activity, transferring pentosyl groups

Cellular Component

None predicted.