Protein

MCA_05500_1

Length
509 amino acids

Gene name: SGS1B

Description: ATP-dependent DNA helicase

Browser: contigD:1480844-1482374+

RNA-seq: read pairs 310, FPKM 7.5, percentile rank 21.4% (100% = highest expression)

Protein function

Annotation:SGS1BATP-dependent DNA helicase
KEGG:K10901BLM bloom syndrome protein [EC:3.6.4.12]
EGGNOG:0PI3RFG00626.1DNA- helicase
SGD closest match:S000004802SGS1ATP-dependent helicase SGS1
CGD closest match:CAL0000185821SGS1ATP-dependent DNA helicase

Protein alignments

%idAln lengthE-value
MIA_02797_155.53%4970.0MIA_02797_1
A0A0J9XHH8_GEOCN48.89%4951e-169Similar to Saccharomyces cerevisiae YMR190C SGS1 Nucleolar DNA helicase of the RecQ family OS=Geotrichum candidum GN=BN980_GECA15s00626g PE=4 SV=1
UniRef50_A0A0J9XHH848.89%4953e-166Similar to Saccharomyces cerevisiae YMR190C SGS1 Nucleolar DNA helicase of the RecQ family n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XHH8_GEOCN
Q6C1E1_YARLI42.86%4975e-133YALI0F17116p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F17116g PE=4 SV=1
A0A060T2X9_BLAAD40.75%5084e-124ARAD1C32494p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C32494g PE=4 SV=1
A0A167C7W9_9ASCO46.03%4283e-121ATP-dependent DNA helicase SGS1 OS=Sugiyamaella lignohabitans GN=SGS1 PE=4 SV=1
A0A1E4TE35_9ASCO37.37%4874e-91Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_24928 PE=4 SV=1
Q5A5R4_CANAL35.09%4932e-80ATP-dependent DNA helicase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SGS1 PE=4 SV=1
SGS1_YEAST33.53%5045e-78ATP-dependent helicase SGS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SGS1 PE=1 SV=1
A0A1E3PG93_9ASCO35.55%4816e-75ATP-dependent DNA helicase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_27084 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.3920

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 50 100 150 200 250 300 350 400 450 509

Detailed signature matches

  1. Family IPR004589
    DNA helicase, ATP-dependent, RecQ type
    1. TIGR00614
  2. Domain IPR014001
    Helicase superfamily 1/2, ATP-binding domain
    1. PS51192 (HELICASE_A...)
    2. SM00487 (ultradead3)
  3. Domain IPR011545
    DEAD/DEAH box helicase domain
    1. PF00270 (DEAD)
  4. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  5. Domain IPR001650
    Helicase, C-terminal
    1. PS51194 (HELICASE_CTER)
    2. SM00490 (helicmild6)
    3. PF00271 (Helicase_C)
  6. Domain IPR032284
    ATP-dependent DNA helicase RecQ, zinc-binding domain
    1. PF16124 (RecQ_Zn_bind)
  7. SITE IPR002464
    DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
    1. PS00690 (DEAH_ATP_H...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:3.40.50...
  3. cd00046 (DEXDc)
  4. cd00079 (HELICc)
  5. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. putative Mg++ bind...
  3. nucleotide binding...
  4. ATP-binding site c...

Protein sequence

>MCA_05500_1
MNARPSLNDLLSVLNSYFGKTTFRSHQEEIIRAALQGHDLLVILPTGHGKSLTYQLPAIASSHLPQLRNQDGVTVVISPL
ISLMQDQVANLNKKNINAVTLNGTTPQAERNRVLHDLTNRRPRSKPPDTKLLYVSPELCGTEAFRKVLKTLVRNSHLSRF
VIDEAHCCVEWGYDFRSSYIDLSYLKTHFPNVPITALSATASEKAKKQIVSILKLGTVSELKVFSTSVNRPNLHYEVQYL
DSHDYTEVIIPKLVKFHKDYEERRKRAADEISSLISAEEYQGNIPAWIKDSIPKPGSVGAGIIYCRKKSTVELITEHLND
NSIGAHAYHAGLPKSHRESVLSNWVNNEPGYDVVVATVAFGMGIDKEDVRFVIHVDCPGSIESYFQATGRAGRDGKAARC
VLYYSREDRNRLIALERNNKYKLGSGKRSKRRKDDSDDEIDDEETPSGLNSMIHYCENTYTCRHLILCSYFEKDVPKRPN
KEWCYYACDYCKDPRELLNQSSIMAYDYD

GO term prediction

Biological Process

GO:0006310 DNA recombination

Molecular Function

GO:0003676 nucleic acid binding
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity

Cellular Component

None predicted.