Protein

MCA_05417_1

Length
379 amino acids

Gene name: ERG6

Description: Sterol 24-C-methyltransferase

Browser: contigD:1276031-1277171+

RNA-seq: read pairs 13606, FPKM 442.4, percentile rank 93.8% (100% = highest expression)

Protein function

Annotation:ERG6Sterol 24-C-methyltransferase
KEGG:K00559E2.1.1.41 sterol 24-C-methyltransferase [EC:2.1.1.41]
EGGNOG:0PH10ERG6Sterol 24-c-methyltransferase
SGD closest match:S000004467ERG6Sterol 24-C-methyltransferase
CGD closest match:CAL0000189580ERG6Sterol 24-C-methyltransferase

Protein alignments

%idAln lengthE-value
MIA_03598_184.08%3770.0MIA_03598_1
A0A0J9XJ46_GEOCN77.01%3740.0Sterol 24-C-methyltransferase OS=Geotrichum candidum GN=BN980_GECA22s00912g PE=3 SV=1
A0A161HFZ4_9ASCO76.00%3750.0Sterol 24-C-methyltransferase OS=Sugiyamaella lignohabitans GN=ERG6 PE=3 SV=1
A0A060T2N3_BLAAD73.87%3750.0Sterol 24-C-methyltransferase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A09900g PE=3 SV=1
A0A1E3PLQ7_9ASCO73.12%3720.0Sterol 24-C-methyltransferase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_50292 PE=3 SV=1
ERG6_CANAL71.51%3720.0Sterol 24-C-methyltransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ERG6 PE=3 SV=2
UniRef50_O7419871.51%3720.0Sterol 24-C-methyltransferase n=93 Tax=Fungi TaxID=4751 RepID=ERG6_CANAL
ERG6_YARLI66.32%3800.0Sterol 24-C-methyltransferase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=ERG6 PE=3 SV=1
A0A1E4TKD1_9ASCO62.94%3675e-176Sterol 24-C-methyltransferase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_83603 PE=3 SV=1
ERG6_YEAST62.94%3672e-169Sterol 24-C-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ERG6 PE=1 SV=4

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2240

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 379

Detailed signature matches

  1. Domain IPR029063
    S-adenosyl-L-methionine-dependent methyltransferase
    1. SSF53335 (S-adenosy...)
  2. Domain IPR030384
    SAM-dependent methyltransferase SMT-type
    1. PS51685 (SAM_MT_ERG...)
  3. Domain IPR013216
    Methyltransferase type 11
    1. PF08241 (Methyltran...)
  4. Domain IPR013705
    Sterol methyltransferase C-terminal
    1. PF08498 (Sterol_MT_C)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. cd02440 (AdoMet_MTases)

Residue annotation

  1. S-adenosylmethioni...

Protein sequence

>MCA_05417_1
MATLTKLAPKDFKSDAEFAKALHGSDTSKAGYAALLKKNTSAQEAAVDGYFKHWDNKNSETQTTEDQQSRLDDYSSLTKH
YYNLVTDFYEYGWGSSFHFSRYYPGEAFRQATARHEHFLAYKMGIKEDMKVLDVGCGVGGPAREIHRFTGATVVGLNNND
YQVEKANHYAKVNNLSDKLSFVKGDFMQMDFEPESFDAVYAIEATVHAPVLEGVYSEIYKVLKPGGVFGVYEWVLTDKFD
ETNPKHREIAYGIEVGDGIPKMYTRKVAEQALKNVGFEVEFEKDMSDVNDSIPWYYPLSGEWRYVQTVGDLFTFFRTSKI
GRQVTMNLTGLLEKLHIAPPGSKKVTIALEEAAVNLVEGAKLGIFTPMMLYVCKKPETQ

GO term prediction

Biological Process

GO:0006694 steroid biosynthetic process
GO:0008152 metabolic process

Molecular Function

GO:0008168 methyltransferase activity

Cellular Component

None predicted.