Protein

MCA_05405_1

Length
889 amino acids

Gene name: ARG5,6

Description: Protein ARG5,6, mitochondrial; Acetylglutamate kinase

Browser: contigD:1241136-1243925+

RNA-seq: read pairs 8618, FPKM 119.6, percentile rank 81.8% (100% = highest expression)

Protein function

Annotation:ARG5,6Protein ARG5,6, mitochondrial; Acetylglutamate kinase
KEGG:K12659ARG56 N-acetyl-gamma-glutamyl-phosphate reductase / acetylglutamate kinase [EC:1.2.1.38 2.7.2.8]
EGGNOG:0PFGYPGUG_01843Acetylglutamate kinase
SGD closest match:S000000871ARG5,6Protein ARG5,6, mitochondrial
CGD closest match:CAL0000175409ARG5,6Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase

Protein alignments

%idAln lengthE-value
MIA_00283_181.79%8950.0MIA_00283_1
A0A0J9XA35_GEOCN78.25%8920.0Similar to Saccharomyces cerevisiae YER069W ARG5,6 Protein that is processed in the mitochondrion to yield acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase OS=Geotrichum candidum GN=BN980_GECA06s03849g PE=4 SV=1
A0A167DZM2_9ASCO73.83%8940.0Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase OS=Sugiyamaella lignohabitans GN=ARG5,6 PE=4 SV=1
A0A060T9H6_BLAAD72.26%8940.0ARAD1D11990p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D11990g PE=4 SV=1
A0A1E3PK52_9ASCO70.59%9010.0Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47021 PE=4 SV=1
A0A1E4TA76_9ASCO71.72%8240.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_3324 PE=4 SV=1
UniRef50_F2QTU070.22%8360.0Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase n=18 Tax=Ascomycota TaxID=4890 RepID=F2QTU0_KOMPC
Q6CE87_YARLI70.93%8360.0YALI0B17666p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B17666g PE=4 SV=1
A0A1D8PEI6_CANAL65.89%8970.0Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ARG5,6 PE=4 SV=1
ARG56_YEAST63.97%8770.0Protein ARG5,6, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ARG5,6 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9996
Predicted cleavage: 65

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 700 800 889

Detailed signature matches

  1. Family IPR011241
    Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase
    1. PIRSF036440 (ARG5-6)
  2. Family IPR004662
    Acetylglutamate kinase
    1. TIGR00761
  3. Family IPR000706
    N-acetyl-gamma-glutamyl-phosphate reductase, type 1
    1. TIGR01850
  4. Domain IPR001048
    Aspartate/glutamate/uridylate kinase
    1. SSF53633 (Carbamate...)
    2. PF00696 (AA_kinase)
  5. Domain IPR006855
    Vertebrate-like NAGS Gcn5-related N-acetyltransferase (GNAT) domain
    1. PS51731 (GNAT_NAGS)
    2. PF04768 (NAT)
  6. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
  7. Domain IPR000534
    Semialdehyde dehydrogenase, NAD-binding
    1. SM00859 (Semialdhyd...)
    2. PF01118 (Semialdhyd...)
  8. SITE IPR023013
    N-acetyl-gamma-glutamyl-phosphate reductase, active site
    1. PS01224 (ARGC)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.30.36...
  2. G3DSA:3.40.11...
  3. G3DSA:3.40.50...
  4. G3DSA:3.40.63...
  5. SSF55347 (Glycerald...)
  6. cd04252 (AAK_NAGK-f...)
  7. cd04263 (DUF619-NAG...)
  8. mobidb-lite (disord...)

Residue annotation

  1. putative nucleotid...
  2. putative N-acetyl-...

Protein sequence

>MCA_05405_1
MIRTVGRQSVKSLLRSTTVARSARVAAFHTTSSLPAPSGVQVNQQAEKRQKKSLNSARSYSTRSTVIQLLDSIGSKREVE
QYLKYFTSVSNQQFAVIKVGGAVITDNLEELSSSLAFLYHVGLYPIVLHGTGPQINAVLESQGIVPDYIDGIRITDSRTM
SVVRKMFLQQNLKLVEALEKLGVRARPITGGVFTADYLDKEKYHLVGKITSVDKTPIEASINAGVLPILTSLAETTDGQI
LNVNADVAAGELARVIEPLKIVYLNEKGGLINGATGEKISVINLDEEYDDLMKESWVKYGTKLKIKEIKELLTYLPRSSS
VAIISVHDLQKELFTDTGAGTLIRRGYKLLSRNNLEQFPSQEALRKALQRDPAIANRKVSVASYLRSLEGVSFMAYGDEP
LEVLAIVKNDQSTPVLDKFLSSKNGWLNSVTDNVWSAIRKDYPSLQWVVSEQDENSPWHFSKADGSFAKDGKILFWYGIS
DPAVISKLIADFSAKVSAELAEAAAVNGSSASGPKIQTRSFSTFTRASSIFSRGPMMRSNMKFGMRSYSTNPNPPLKDGN
NNKPAKVALIGARGYTGQALIDLINKHPYLELSHVSSRELAGTPLNGYDKQRIIYESLQVEDIKRLEERGDVDVWVMALP
NGVCKPFVDAISNANSAKKSVIIDLSADYRFDETKEWLYGLPELGNRKDYATARKISNPGCYATAAQLAIAPILEHLGEG
QPTVFGVSGYSGAGTKPSPKNDLKVLTNNLIPYSLTDHIHEREVSRQLGTQIAFTPHVAQWFQGITHTISIPLKTKLTSR
EIRNLYQDRYAGEKLIHVTGESPLVRDISGKHGVIIGGFGVSSRQDRVVIVATIDNLLKGAATQCLQNINLALGYGEYDG
IPVDFSIRG

GO term prediction

Biological Process

GO:0006526 arginine biosynthetic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0003942 N-acetyl-gamma-glutamyl-phosphate reductase activity
GO:0003991 acetylglutamate kinase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding

Cellular Component

GO:0005737 cytoplasm
GO:0005739 mitochondrion