Protein

MCA_05338_1

Length
984 amino acids

Gene name: SEC26

Description: Coatomer subunit beta

Browser: contigD:1057760-1060715-

RNA-seq: read pairs 9558, FPKM 119.9, percentile rank 81.8% (100% = highest expression)

Protein function

Annotation:SEC26Coatomer subunit beta
KEGG:K17301COPB1 coatomer subunit beta
EGGNOG:0PHGHSEC26The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity)
SGD closest match:S000002646SEC26Coatomer subunit beta
CGD closest match:CAL0000198602SEC26Coatomer subunit beta

Protein alignments

%idAln lengthE-value
MIA_03220_173.91%9850.0MIA_03220_1
A0A0J9XBQ6_GEOCN66.80%9760.0Coatomer subunit beta OS=Geotrichum candidum GN=BN980_GECA09s01594g PE=4 SV=1
A0A161HI75_9ASCO63.25%9660.0Coatomer subunit beta OS=Sugiyamaella lignohabitans GN=SEC26 PE=4 SV=1
A0A060T5N3_BLAAD60.44%9580.0Coatomer subunit beta OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B13156g PE=4 SV=1
A0A1E3PQ62_9ASCO56.57%9740.0Coatomer subunit beta OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_22339 PE=4 SV=1
Q6C157_YARLI54.07%9840.0Coatomer subunit beta OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F19074g PE=4 SV=1
UniRef50_A0A0D2GMS454.88%9730.0Rhinocladiella mackenziei CBS 650.93 unplaced genomic scaffold supercont1.11, whole genome shotgun sequence n=4 Tax=leotiomyceta TaxID=716546 RepID=A0A0D2GMS4_9EURO
Q5A6M6_CANAL53.91%9850.0Coatomer subunit beta OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SEC26 PE=4 SV=1
COPB_YEAST49.14%9830.0Coatomer subunit beta OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SEC26 PE=1 SV=2
A0A1E4TKJ2_9ASCO45.43%9730.0Coatomer subunit beta OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_84497 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0261

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 700 800 900 984

Detailed signature matches

  1. Family IPR016460
    Coatomer beta subunit (COPB1)
    1. PIRSF005727 (Beta-COP)
  2. Domain IPR016024
    Armadillo-type fold
    1. SSF48371 (ARM repeat)
  3. Domain IPR011989
    Armadillo-like helical
    1. G3DSA:1.25.10.10
  4. Domain IPR002553
    Clathrin/coatomer adaptor, adaptin-like, N-terminal
    1. PF01602 (Adaptin_N)
  5. Domain IPR011710
    Coatomer beta subunit, C-terminal
    1. PF07718 (Coatamer_b...)
  6. Domain IPR029446
    Coatomer beta subunit, appendage platform domain
    1. PF14806 (Coatomer_b...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. Coil
  3. G3DSA:3.30.31...
  4. NON_CYTOPLASM... (N...)
  5. TRANSMEMBRANE (Tran...)
  6. mobidb-lite (disord...)

Protein sequence

>MCA_05338_1
MADLAPYALIYDATPTDKPSVQEFKDLLEKGTDKVKIAVMKRILVIMINGDPMPQLLMHILRFVMPSKNKELKKLLHFYW
EVCPKVNPDGTLRQEMILVCNALRNDLQHHNEYIRGATLRALCKLHEAELLDPLIPSVISCLEHRHAYVRKNAIFAVYTI
ASEPSTSHHIPDAPETIQTFLDNETDDTCIRNAFIALSNLDRERALTFIQQKIQSIDSLDELLQLAIIEFVCRDAVHHPE
LKPIYLKIIFDILDSSSNTAVYEAANALTRISSDQNAIKGAATKLVELALKEPDNNVKLIVFEQVERLHLKNPGVLNELT
MEILAALSTPDLDVRKKALDISLGMVTSRNVDDVIKLLKKELNKTLSQDYDKNSEYRQYLIQAIHTCAIRFVEVARSVVE
MLLDLLGDESTSSTNSAVEVISFVKEVVEIFPDLRADLVAKLLHTLDNVRSGSVYRGALWVIGEYSYSEQEIKSVWAHIR
KSLGEVPILSSEQRLLREADSSEETQANGTVEPEHKSSKPKVLSDGTYATETAFSVSQKAQDDVKSNRPPLRALILSGSW
FLASVLAGTLAKLAIRALKVSKNEAFKNALRAEAMLIMISIIRVGESSIVSSKIDEDTIDRIYSCVKVLAEGYNEESLDK
AFLEDSRKAFKAQVEAREKKRAESDAKEVNKNASQIDTSLTFRQLSAISTASENSDANIDQDLVLASGTSADLSAQKPTS
KLSRIVQLTGYSDPVYVEAYVNVHQFDIVLDVLVFNQTLDTLQNLTVEFATLGDLKLSSKPTPQNIGPQSFHSVQATIKV
SSADTGVIFGNIIYEGQTAGDNTIVILNDIHVDIMDYIKPGNYNETEFRTMWAEFEWENNVNISVPGKSLRGFLKYLMKN
TNMQCLTPGALEGGAKVFGLDEEEEKDEEEEEEECKFLSANLHARSKFGEDALANLSIERSEQTGRIVGHVRIRSKGQGL
ALSLGDRVAELQRQKITQSISQSA

GO term prediction

Biological Process

GO:0006886 intracellular protein transport
GO:0016192 vesicle-mediated transport

Molecular Function

GO:0005198 structural molecule activity
GO:0005488 binding

Cellular Component

GO:0005737 cytoplasm
GO:0030117 membrane coat
GO:0030126 COPI vesicle coat