MCA_05322_1

Protein

Length

478 amino acids

Gene name: DUG1A

Description: Cys-Gly metallodipeptidase DUG1

Browser: contigD:1009462-1011165-

RNA-seq: read pairs 11532, FPKM 297.5, percentile rank 91.8% (100% = highest expression)

Protein function

Annotation:		DUG1A	Cys-Gly metallodipeptidase DUG1
KEGG:	K15428	DUG1	Cys-Gly metallodipeptidase DUG1 [EC:3.4.13.-]
EGGNOG:	0PHND	FG09893.1	glutamate carboxypeptidase
SGD closest match:	S000001940	DUG1	Cys-Gly metallodipeptidase DUG1
CGD closest match:	CAL0000193256	DUG1	Cys-Gly metallodipeptidase DUG1

Protein alignments

	%id	Aln length
MIA_01553_1	81.80%	478	MIA_01553_1
A0A0J9XHE3_GEOCN	80.33%	478	Similar to Saccharomyces cerevisiae YFR044C DUG1 Cys-Gly metallo-di-peptidase OS=Geotrichum candidum GN=BN980_GECA16s02397g PE=4 SV=1
A0A060T1K2_BLAAD	76.21%	475	ARAD1C25366p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C25366g PE=4 SV=1
A0A161HGA0_9ASCO	77.83%	433	Metallodipeptidase OS=Sugiyamaella lignohabitans GN=DUG1 PE=4 SV=1
A0A1E3PPE0_9ASCO	68.55%	477	Glutamate carboxypeptidase-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49730 PE=4 SV=1
Q6C1A8_YARLI	66.39%	476	YALI0F17842p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F17842g PE=4 SV=1
A0A1E4TJT4_9ASCO	63.50%	474	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30276 PE=4 SV=1
DUG1_CANAL	64.97%	471	Cys-Gly metallodipeptidase DUG1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=DUG1 PE=1 SV=1
DUG1_YEAST	60.04%	473	Cys-Gly metallodipeptidase DUG1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DUG1 PE=1 SV=1
UniRef50_P43616	60.04%	473	Cys-Gly metallodipeptidase DUG1 n=203 Tax=Eukaryota TaxID=2759 RepID=DUG1_YEAST

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2951

Protein family membership

Peptidase M20 (IPR002933)
- Cytosolic nonspecific dipeptidase/DUG1 (IPR017153)

Domains and repeats

Domain
212 - 367
Peptidase M20, dimerisation domain (IPR011650)

1 50 100 150 200 250 300 350 400 450 478

Detailed signature matches

IPR002933

Peptidase M20
1. PF01546 (Peptidase_M20)
  
  96 - 468
  
  Pfam
  PF01546 (Peptidase_M20)
IPR017153

Cytosolic nonspecific dipeptidase/DUG1
1. cd05676 (M20_dipept...)
  
  9 - 473
  
  CDD
  cd05676 (M20_dipept_like_CNDP)
2. PIRSF037242 (CNDP_d...)
  
  1 - 476
  
  PIRSF
  PIRSF037242 (CNDP_dipeptidase)
IPR011650

Peptidase M20, dimerisation domain
1. PF07687 (M20_dimer)
  
  212 - 367
  
  Pfam
  PF07687 (M20_dimer)
IPR001261

ArgE/DapE/ACY1/CPG2/YscS, conserved site
1. PS00759 (ARGE_DAPE_...)
  
  131 - 170
  
  PROSITE patterns
  PS00759 (ARGE_DAPE_CPG2_2)

no IPR

Unintegrated signatures

G3DSA:3.30.70...

216 - 384

GENE3D
G3DSA:3.30.70.360 (G3DSA:3.30.70.360)
G3DSA:3.40.63...

9 - 215

GENE3D
G3DSA:3.40.630.10 (G3DSA:3.40.630.10)
SSF53187 (Zn-depend...)

386 - 471

SUPERFAMILY
SSF53187 (Zn-dependent exopeptidases)

7 - 212

SUPERFAMILY
SSF53187 (Zn-dependent exopeptidases)

Residue annotation

metal binding site...

100H

metal binding site
100H, 133D, 167E, 168E, 196D, 446H
CDD
cd05676 (M20_dipept_like_CNDP)

133D

metal binding site
100H, 133D, 167E, 168E, 196D, 446H
CDD
cd05676 (M20_dipept_like_CNDP)

167E

metal binding site
100H, 133D, 167E, 168E, 196D, 446H
CDD
cd05676 (M20_dipept_like_CNDP)

168E

metal binding site
100H, 133D, 167E, 168E, 196D, 446H
CDD
cd05676 (M20_dipept_like_CNDP)

196D

metal binding site
100H, 133D, 167E, 168E, 196D, 446H
CDD
cd05676 (M20_dipept_like_CNDP)

446H

metal binding site
100H, 133D, 167E, 168E, 196D, 446H
CDD
cd05676 (M20_dipept_like_CNDP)
active site cd05676

100H

active site
100H, 133D, 167E, 168E, 196D, 198Y, 211V, 344R, 381H, 415E, 417G, 418S, 419I, 446H
CDD
cd05676 (M20_dipept_like_CNDP)

133D

active site
100H, 133D, 167E, 168E, 196D, 198Y, 211V, 344R, 381H, 415E, 417G, 418S, 419I, 446H
CDD
cd05676 (M20_dipept_like_CNDP)

167E

active site
100H, 133D, 167E, 168E, 196D, 198Y, 211V, 344R, 381H, 415E, 417G, 418S, 419I, 446H
CDD
cd05676 (M20_dipept_like_CNDP)

168E

active site
100H, 133D, 167E, 168E, 196D, 198Y, 211V, 344R, 381H, 415E, 417G, 418S, 419I, 446H
CDD
cd05676 (M20_dipept_like_CNDP)

196D

active site
100H, 133D, 167E, 168E, 196D, 198Y, 211V, 344R, 381H, 415E, 417G, 418S, 419I, 446H
CDD
cd05676 (M20_dipept_like_CNDP)

198Y

active site
100H, 133D, 167E, 168E, 196D, 198Y, 211V, 344R, 381H, 415E, 417G, 418S, 419I, 446H
CDD
cd05676 (M20_dipept_like_CNDP)

211V

active site
100H, 133D, 167E, 168E, 196D, 198Y, 211V, 344R, 381H, 415E, 417G, 418S, 419I, 446H
CDD
cd05676 (M20_dipept_like_CNDP)

344R

active site
100H, 133D, 167E, 168E, 196D, 198Y, 211V, 344R, 381H, 415E, 417G, 418S, 419I, 446H
CDD
cd05676 (M20_dipept_like_CNDP)

381H

active site
100H, 133D, 167E, 168E, 196D, 198Y, 211V, 344R, 381H, 415E, 417G, 418S, 419I, 446H
CDD
cd05676 (M20_dipept_like_CNDP)

415E

active site
100H, 133D, 167E, 168E, 196D, 198Y, 211V, 344R, 381H, 415E, 417G, 418S, 419I, 446H
CDD
cd05676 (M20_dipept_like_CNDP)

417G

active site
100H, 133D, 167E, 168E, 196D, 198Y, 211V, 344R, 381H, 415E, 417G, 418S, 419I, 446H
CDD
cd05676 (M20_dipept_like_CNDP)

418S

active site
100H, 133D, 167E, 168E, 196D, 198Y, 211V, 344R, 381H, 415E, 417G, 418S, 419I, 446H
CDD
cd05676 (M20_dipept_like_CNDP)

419I

active site
100H, 133D, 167E, 168E, 196D, 198Y, 211V, 344R, 381H, 415E, 417G, 418S, 419I, 446H
CDD
cd05676 (M20_dipept_like_CNDP)

446H

active site
100H, 133D, 167E, 168E, 196D, 198Y, 211V, 344R, 381H, 415E, 417G, 418S, 419I, 446H
CDD
cd05676 (M20_dipept_like_CNDP)
dimer interface cd...

104Q

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

110D

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

212R

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

214C

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

216Y

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

218S

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

224P

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

225A

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

226A

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

227D

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

229H

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

230S

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

231G

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

232L

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

233F

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

234G

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

235G

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

236V

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

237A

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

238H

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

239E

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

241M

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

245A

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

248F

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

249S

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

252V

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

253T

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

254P

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

288L

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

291N

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

292I

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

293G

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

296T

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

297I

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

305A

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

308A

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

309R

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

314S

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

315L

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

316S

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

317I

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

318H

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

319G

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

320V

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

321E

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

325S

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

326S

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

327A

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

328G

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

329A

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

330K

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

331T

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

332V

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

334P

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

335A

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

340K

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

344R

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

369L

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

370G

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

372K

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

381H

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

416G

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

417G

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

445A

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

446H

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

447S

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

448T

dimer interface
104Q, 110D, 212R, 214C, 216Y, 218S, 224P, 225A, 226A, 227D, 229H, 230S, 231G, 232L, 233F, 234G, 235G, 236V, 237A, 238H, 239E, 241M, 245A, 248F, 249S, 252V, 253T, 254P, 288L, 291N, 292I, 293G, 296T, 297I, 305A, 308A, 309R, 314S, 315L, 316S, 317I, 318H, 319G, 320V, 321E, 325S, 326S, 327A, 328G, 329A, 330K, 331T, 332V, 334P, 335A, 340K, 344R, 369L, 370G, 372K, 381H, 416G, 417G, 445A, 446H, 447S, 448T
CDD
cd05676 (M20_dipept_like_CNDP)

Protein sequence

>MCA_05322_1
MSEENIQKFFERVDTLKSQYITRLADAVAIPSVSAEPDRRPEVVKMAKWLEAQLTELGVTDIELKELGEQEDAPGLHLPP
IVVGRYGTDPAKKNVLIYGHYDVQPAEIEDGWNSDPFTLVEKDDILFGRGSSDDKGPVVCWLNVIQAHRELGIELPVNLT
FCFEGMEESGSLGLEELVKAEKDKYFKGVDAVCISDNYWLGTKHPVLTYGVRGCNYYSITIEGPAADLHSGLFGGVAHEP
MVDLAHVFSKLVTPSGEILIPGIKEMVAPLTPEEDALYDALNFDLEGLENNIGSKTIIKDNIKDALQARWRFPSLSIHGV
EGAFSSAGAKTVIPAKVVGKFSIRTVPNIESKKLDEIVIKYVEDVFAQLGSKNKCKAALVHDGAYWVTDPKNWSFRAAAK
ATKAVWGVEPDYTREGGSIPITLTFQDVLNTSVILLPVGRGDDGAHSTNEKINISNYIQGTKTLGAYLHYLSTEEKDA

GO term prediction

Biological Process

GO:0006508 proteolysis
GO:0008152 metabolic process

Molecular Function

GO:0008237 metallopeptidase activity
GO:0016787 hydrolase activity
GO:0016805 dipeptidase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features