Protein

MCA_05277_1

Length
448 amino acids

Browser: contigD:848604-850434+

RNA-seq: read pairs 7689, FPKM 211.6, percentile rank 88.8% (100% = highest expression)

Protein function

KEGG:K01641E2.3.3.10 hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10]
EGGNOG:0PG2NFG09266.1Hydroxymethylglutaryl-CoA synthase
SGD closest match:S000004595ERG13Hydroxymethylglutaryl-CoA synthase
CGD closest match:CAL0000197068ERG13Hydroxymethylglutaryl-CoA synthase

Protein alignments

%idAln lengthE-value
MIA_05906_179.82%4510.0MIA_05906_1
A0A0J9X4Q8_GEOCN76.79%4480.0Hydroxymethylglutaryl-CoA synthase OS=Geotrichum candidum GN=BN980_GECA02s05961g PE=3 SV=1
A0A060TFI7_BLAAD76.79%4480.0Hydroxymethylglutaryl-CoA synthase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D15664g PE=3 SV=1
Q6BZW0_YARLI71.30%4460.0Hydroxymethylglutaryl-CoA synthase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F30481g PE=3 SV=1
UniRef50_A0A1L0BSL470.65%4430.0CIC11C00000001312 n=1 Tax=[Candida] intermedia TaxID=45354 RepID=A0A1L0BSL4_9ASCO
A0A1D8PTW6_CANAL68.01%4470.0Hydroxymethylglutaryl-CoA synthase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ERG13 PE=3 SV=1
A0A167CLP5_9ASCO73.63%4020.0Hydroxymethylglutaryl-CoA synthase OS=Sugiyamaella lignohabitans GN=ERG13 PE=3 SV=1
HMCS_YEAST64.68%4530.0Hydroxymethylglutaryl-CoA synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ERG13 PE=1 SV=1
A0A1E3PS90_9ASCO70.50%4000.0Hydroxymethylglutaryl-CoA synthase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_44900 PE=3 SV=1
A0A1E4TB06_9ASCO58.85%4520.0Hydroxymethylglutaryl-CoA synthase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_130700 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2042

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 448

Detailed signature matches

  1. Family IPR010122
    Hydroxymethylglutaryl-CoA synthase, eukaryotic
    1. TIGR01833
  2. Domain IPR016039
    Thiolase-like
    1. SSF53901 (Thiolase-...)
    2. G3DSA:3.40.47.10
  3. Domain IPR013528
    Hydroxymethylglutaryl-coenzyme A synthase, N-terminal
    1. PF01154 (HMG_CoA_sy...)
  4. Domain IPR013746
    Hydroxymethylglutaryl-coenzyme A synthase C-terminal domain
    1. PF08540 (HMG_CoA_sy...)
  5. SITE IPR000590
    Hydroxymethylglutaryl-coenzyme A synthase, active site
    1. PS01226 (HMG_COA_SY...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. cd00827 (init_cond_...)

Residue annotation

  1. dimer interface cd...
  2. active site cd00827

Protein sequence

>MCA_05277_1
MTSSSIERPQNIGIKAFEIYIPGQAVNQTELEKFSNIPAGKFTIGLGQTNMAFVNDREDIYSFALTAVSNLLKKNNIDPN
SIGRLDVGTETLLDKSKSVKSVLMQLFGENSDIEGIDSVNACYGGTNSLFNAINWIESSSWDGRDAIVVAGDIAIYSKGA
ARPTGGAGAVAFLIGPDAPLVFDPVHGSHMEHAYDFYKPDFTSEYPVVDGHFSLTCYTKALDKAYQAYNKKAAKKGLSGT
TASGMDRFDYSVFHVPTCKLVSKSFARLFYNDWLNDKSALDLPEELQGLTYEQSLVDKNLEKVLVGLVKDKSAKRMAPSL
IGPTNTGNMYTASVFSSLASLLTFVPTENLQGKRISLFSYGSGLAASFYSLVVKGDISDIVKNLDLKNKLDSRAIQSPEE
FEAAIALREKIHLQKDFTPTGSIENLPSGTYYLVNINDKFQREYAVKE

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0008299 isoprenoid biosynthetic process

Molecular Function

GO:0003824 catalytic activity
GO:0004421 hydroxymethylglutaryl-CoA synthase activity

Cellular Component

None predicted.