Protein

MCA_05231_1

Length
828 amino acids

Browser: contigD:690594-693081-

RNA-seq: read pairs 3427, FPKM 51.1, percentile rank 65.9% (100% = highest expression)

Protein function

KEGG:K01886QARS glutaminyl-tRNA synthetase [EC:6.1.1.18]
EGGNOG:0PG6PFG02555.1Glutaminyl-tRNA synthetase
SGD closest match:S000005694GLN4Glutamine--tRNA ligase
CGD closest match:CAL0000198388GLN4Glutamine--tRNA ligase

Protein alignments

%idAln lengthE-value
MIA_01966_179.44%8270.0MIA_01966_1
S4SV80_GEOCN72.46%8280.0Glutaminyl-tRNA synthase OS=Geotrichum candidum GN=Gln4 PE=3 SV=1
A0A1E3PCB0_9ASCO68.15%8290.0Glutaminyl-tRNA synthetase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84550 PE=3 SV=1
A0A167CRW5_9ASCO65.63%8350.0Glutamine--tRNA ligase OS=Sugiyamaella lignohabitans GN=GLN4 PE=3 SV=1
A0A060TBF6_BLAAD66.67%8220.0ARAD1D27566p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D27566g PE=3 SV=1
Q6CD53_YARLI61.67%8270.0YALI0C03674p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C03674g PE=3 SV=1
SYQ_YEAST58.79%8250.0Glutamine--tRNA ligase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GLN4 PE=1 SV=2
UniRef50_P1318858.79%8250.0Glutamine--tRNA ligase n=111 Tax=Eukaryota TaxID=2759 RepID=SYQ_YEAST
A0A1E4TD92_9ASCO62.45%7030.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_142693 PE=3 SV=1
A0A1D8PQM9_CANAL55.61%8290.0Glutamine--tRNA ligase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=GLN4 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1751

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 700 828

Detailed signature matches

  1. Family IPR000924
    Glutamyl/glutaminyl-tRNA synthetase
    1. PR00987 (TRNASYNTHGLU)
  2. Family IPR004514
    Glutamine-tRNA synthetase
    1. TIGR00440
  3. Domain IPR007639
    Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal
    1. PF04558 (tRNA_synt_...)
  4. Domain IPR007638
    Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain 2
    1. PF04557 (tRNA_synt_...)
  5. Domain IPR020058
    Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain
    1. PF00749 (tRNA-synt_1c)
  6. Domain IPR014729
    Rossmann-like alpha/beta/alpha sandwich fold
    1. G3DSA:3.40.50...
  7. Domain IPR020061
    Glutamyl/glutaminyl-tRNA synthetase, class Ib, alpha-bundle domain
    1. G3DSA:1.10.11...
  8. Domain IPR011035
    Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain
    1. SSF50715 (Ribosomal...)
  9. Domain IPR020059
    Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain
    1. PF03950 (tRNA-synt_...)
  10. Domain IPR020056
    Ribosomal protein L25/Gln-tRNA synthetase, beta-barrel domain
    1. G3DSA:2.40.24...
  11. SITE IPR001412
    Aminoacyl-tRNA synthetase, class I, conserved site
    1. PS00178 (AA_TRNA_LI...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. SSF52374 (Nucleotid...)
  2. cd00807 (GlnRS_core)
  3. mobidb-lite (disord...)

Residue annotation

  1. active site cd00807
  2. HIGH motif cd00807
  3. KMSKS motif cd00807

Protein sequence

>MCA_05231_1
MSDFTDEQLSTKFAELGLQDKKIKEILKNKKVATALAEVCEELPSSVSKEDANSTLLHSLAVLSKDASPDLKPYRKLVTD
AIADGRLKTNLQLESAWNYVKDNGASSTPAGLDEASGVGIEITADQVAECVAKYIADNKASIEEARYKVVPTILNNVKKL
PELKWASPALFKPIIDKQILELLGPKDDRDLVKKKEKKPKDNNSASKKASANAADDIGTKKAGRSMFTEGFLGALHKPGE
NPQVNPELMKKHLAFTGGKVYTRFPPEPNGYLHIGHSKAITVNFGYAKFHDGKCYLRYDDTNPEAEEEQFFTSILDIVRW
LGFEPFKITYSSDYFDQLYELAEHLIKKDLGYVCFCTAEEMKHNRGIKEDGKGGGERKNCAHHGHSVEENLKYFRDMKDG
KYKKGEAVLRMKQDITNPNPQMWDLVAYRVVDAPHHRTGDKWKIYPTYDFTHCLVDSFENISHSLCTTEFYLSRESYEWL
CDAVDVYKPAQREYGRLNITGTVMSKRKIAKLVNEGYVRGWDDPRLFTLVALRRRGIPPGAILSFVAQLGVTTSNSNIQV
VRFESSIRKFLEDTTPRLMMIPDPVPVILENVADDFYEDISVPFKPGTPEFGEHTVPFTKKIYIDRSDFREEASKDYFRL
APGKSVGLLKIPYNIRVTSYTKDPETGLVTEIRAHYENDIEYKKPKTYIQWIAECPAKGSPVKLEEVRIFDQLFKSDNPS
AHPDGYLADLNENSETCLKNAIIETGFAEVKAKSPWNPSASRPSSSSSSDEEIKAEQCLEGGENKWAPESVRFQALRVGY
FCMDKDSTDDKIILNRIVSLKEDSAKSK

GO term prediction

Biological Process

GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006425 glutaminyl-tRNA aminoacylation
GO:0043039 tRNA aminoacylation

Molecular Function

GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004819 glutamine-tRNA ligase activity
GO:0005524 ATP binding
GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds

Cellular Component

GO:0005737 cytoplasm