MCA_05222_1

Protein

Length

525 amino acids

Gene name: GUA1

Description: GMP synthase [glutamine-hydrolyzing]

Browser: contigD:667975-669553+

RNA-seq: read pairs 5007, FPKM 117.6, percentile rank 81.5% (100% = highest expression)

Protein function

Annotation:		GUA1	GMP synthase [glutamine-hydrolyzing]
KEGG:	K01951	guaA	GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]
EGGNOG:	0PFKK	GUA1	GMP synthase
SGD closest match:	S000004830	GUA1	GMP synthase [glutamine-hydrolyzing]
CGD closest match:	CAL0000179678	GUA1	GMP synthase [glutamine-hydrolyzing]

Protein alignments

	%id	Aln length	E-value
MIA_00956_1	90.67%	525	0.0	MIA_00956_1
A0A0J9XGV8_GEOCN	83.46%	526	0.0	Similar to Saccharomyces cerevisiae YMR217W GUA1 GMP synthase OS=Geotrichum candidum GN=BN980_GECA15s03211g PE=3 SV=1
GUAA_CANAL	82.95%	522	0.0	GMP synthase [glutamine-hydrolyzing] OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=GUA1 PE=3 SV=1
GUAA_YARLI	82.54%	527	0.0	GMP synthase [glutamine-hydrolyzing] OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=GUA1 PE=3 SV=1
A0A161HI04_9ASCO	81.19%	521	0.0	GMP synthase (Glutamine-hydrolyzing) OS=Sugiyamaella lignohabitans GN=GUA1 PE=3 SV=1
A0A1E3PMY3_9ASCO	79.89%	527	0.0	GMP synthase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45803 PE=3 SV=1
UniRef50_Q6CU71	80.27%	522	0.0	GMP synthase [glutamine-hydrolyzing] n=209 Tax=root TaxID=1 RepID=GUAA_KLULA
GUAA_YEAST	80.00%	520	0.0	GMP synthase [glutamine-hydrolyzing] OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GUA1 PE=1 SV=4
A0A060THG0_BLAAD	79.47%	526	0.0	ARAD1D30646p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D30646g PE=3 SV=1
A0A1E4TEH5_9ASCO	29.71%	138	7e-08	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_1893 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1111

Protein family membership

GMP synthase (IPR022955)

Domains and repeats

Domain
10 - 232
Class I glutamine amidotransferase-like (IPR029062)
Glutamine amidotransferase (IPR017926)
GMP synthase, glutamine amidotransferase (IPR004739)
Domain
203 - 400
Rossmann-like alpha/beta/alpha sandwich fold (IPR014729)
GMP synthetase ATP pyrophosphatase domain (IPR025777)
Domain
207 - 525
GMP synthase, C-terminal (IPR001674)

1 50 100 150 200 250 300 350 400 450 500 525

Detailed signature matches

IPR022955

GMP synthase
1. MF_00344 (GMP_synthase)
  
  11 - 525
  
  HAMAP
  MF_00344 (GMP_synthase)
IPR029062

Class I glutamine amidotransferase-like
1. G3DSA:3.40.50...
  
  11 - 212
  
  GENE3D
  G3DSA:3.40.50.880 (G3DSA:3.40.50.880)
2. SSF52317 (Class I g...)
  
  10 - 232
  
  SUPERFAMILY
  SSF52317 (Class I glutamine amidotransferase-like)
IPR017926

Glutamine amidotransferase
1. PF00117 (GATase)
  
  16 - 195
  
  Pfam
  PF00117 (GATase)
2. PS51273 (GATASE_TYPE_1)
  
  13 - 202
  
  PROSITE profiles
  PS51273 (GATASE_TYPE_1)
IPR004739

GMP synthase, glutamine amidotransferase
1. cd01742 (GATase1_GM...)
  
  14 - 193
  
  CDD
  cd01742 (GATase1_GMP_Synthase)
2. TIGR00888
  
  14 - 199
  
  TIGRFAMs
  TIGR00888 (TIGR00888)
IPR025777

GMP synthetase ATP pyrophosphatase domain
1. PS51553 (GMPS_ATP_P...)
  
  203 - 400
  
  PROSITE profiles
  PS51553 (GMPS_ATP_PPASE)
IPR001674

GMP synthase, C-terminal
1. TIGR00884
  
  207 - 525
  
  TIGRFAMs
  TIGR00884 (TIGR00884)
2. cd01997 (GMP_syntha...)
  
  226 - 524
  
  CDD
  cd01997 (GMP_synthase_C)
3. PF00958 (GMP_synt_C)
  
  433 - 524
  
  Pfam
  PF00958 (GMP_synt_C)
IPR014729

Rossmann-like alpha/beta/alpha sandwich fold
1. G3DSA:3.40.50...
  
  213 - 400
  
  GENE3D
  G3DSA:3.40.50.620 (G3DSA:3.40.50.620)

no IPR

Unintegrated signatures

G3DSA:3.30.30...

401 - 525

GENE3D
G3DSA:3.30.300.10 (G3DSA:3.30.300.10)
PR00096 (GATASE)

57 - 66

PRINTS
PR00096 (GATASE)

172 - 185

PRINTS
PR00096 (GATASE)

84 - 95

PRINTS
PR00096 (GATASE)
PR00097 (ANTSNTHASEII)

84 - 95

PRINTS
PR00097 (ANTSNTHASEII)

57 - 66

PRINTS
PR00097 (ANTSNTHASEII)

172 - 185

PRINTS
PR00097 (ANTSNTHASEII)
SSF52402 (Adenine n...)

189 - 446

SUPERFAMILY
SSF52402 (Adenine nucleotide alpha hydrolases-like)
SSF54810 (GMP synth...)

405 - 525

SUPERFAMILY
SSF54810 (GMP synthetase C-terminal dimerisation domain)

Residue annotation

AMP/PPi binding si...

21S

AMP/PPi binding site
21S, 22Q, 61G, 62G, 63P, 89C, 90Y, 137S, 176H
CDD
cd01742 (GATase1_GMP_Synthase)

22Q

AMP/PPi binding site
21S, 22Q, 61G, 62G, 63P, 89C, 90Y, 137S, 176H
CDD
cd01742 (GATase1_GMP_Synthase)

61G

AMP/PPi binding site
21S, 22Q, 61G, 62G, 63P, 89C, 90Y, 137S, 176H
CDD
cd01742 (GATase1_GMP_Synthase)

62G

AMP/PPi binding site
21S, 22Q, 61G, 62G, 63P, 89C, 90Y, 137S, 176H
CDD
cd01742 (GATase1_GMP_Synthase)

63P

AMP/PPi binding site
21S, 22Q, 61G, 62G, 63P, 89C, 90Y, 137S, 176H
CDD
cd01742 (GATase1_GMP_Synthase)

89C

AMP/PPi binding site
21S, 22Q, 61G, 62G, 63P, 89C, 90Y, 137S, 176H
CDD
cd01742 (GATase1_GMP_Synthase)

90Y

AMP/PPi binding site
21S, 22Q, 61G, 62G, 63P, 89C, 90Y, 137S, 176H
CDD
cd01742 (GATase1_GMP_Synthase)

137S

AMP/PPi binding site
21S, 22Q, 61G, 62G, 63P, 89C, 90Y, 137S, 176H
CDD
cd01742 (GATase1_GMP_Synthase)

176H

AMP/PPi binding site
21S, 22Q, 61G, 62G, 63P, 89C, 90Y, 137S, 176H
CDD
cd01742 (GATase1_GMP_Synthase)
candidate oxyanion...

62G

candidate oxyanion hole
62G, 90Y
CDD
cd01742 (GATase1_GMP_Synthase)

90Y

candidate oxyanion hole
62G, 90Y
CDD
cd01742 (GATase1_GMP_Synthase)
catalytic triad cd...

89C

catalytic triad
89C, 176H, 178E
CDD
cd01742 (GATase1_GMP_Synthase)

176H

catalytic triad
89C, 176H, 178E
CDD
cd01742 (GATase1_GMP_Synthase)

178E

catalytic triad
89C, 176H, 178E
CDD
cd01742 (GATase1_GMP_Synthase)
potential glutamin...

93Q

potential glutamine specificity residues
93Q, 138H, 174Q
CDD
cd01742 (GATase1_GMP_Synthase)

138H

potential glutamine specificity residues
93Q, 138H, 174Q
CDD
cd01742 (GATase1_GMP_Synthase)

174Q

potential glutamine specificity residues
93Q, 138H, 174Q
CDD
cd01742 (GATase1_GMP_Synthase)
ATP Binding subdom...

226V

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

227I

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

228G

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

229A

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

230V

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

231S

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

232G

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

233G

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

234V

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

235D

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

236S

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

237T

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

238V

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

239A

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

240S

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

241A

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

242I

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

243M

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

244K

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

245R

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

246A

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

247I

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

248G

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

249D

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

251F

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

252H

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

253A

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

254I

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

255Y

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

256V

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

257D

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

258N

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

259G

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

260L

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

261M

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

263L

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

264Y

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

265E

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

266T

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

267E

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

268N

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

269V

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

270K

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

271K

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

272A

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

273L

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

284V

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

285D

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

286A

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

287G

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

288A

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

289L

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

290F

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

291I

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

292G

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

293K

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

294L

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

295K

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

296G

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

297V

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

298T

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

299D

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

300P

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

301E

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

302K

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

303K

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

304R

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

305K

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

306I

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

307I

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

308G

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

309N

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

310T

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

311F

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

312I

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

313E

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

314V

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

315F

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

316E

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

317E

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

318E

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

319A

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

320A

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

321K

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

332F

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

333L

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

334L

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

335Q

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

336G

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

337T

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

338L

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

339Y

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

340P

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

341D

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

342V

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

343I

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

344E

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

345S

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

346I

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

347S

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

356K

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

357T

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

358H

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

359H

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

360N

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

361V

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

362G

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

363G

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

364L

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

365L

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

370L

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

371K

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

372L

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

373I

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

374E

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

375P

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

376L

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

377R

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

378E

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

379L

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

380F

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

381K

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

382D

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

383E

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

384V

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

385R

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

386K

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

387L

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

388G

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

389E

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

390L

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

391L

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

392E

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

393V

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

394P

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

400R

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

401H

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

402P

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

403F

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

404P

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

405G

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

406P

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

407G

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

408L

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

409A

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

410I

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

411R

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

412I

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

413L

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)

414G

ATP Binding subdomain
226V, 227I, 228G, 229A, 230V, 231S, 232G, 233G, 234V, 235D, 236S, 237T, 238V, 239A, 240S, 241A, 242I, 243M, 244K, 245R, 246A, 247I, 248G, 249D, 251F, 252H, 253A, 254I, 255Y, 256V, 257D, 258N, 259G, 260L, 261M, 263L, 264Y, 265E, 266T, 267E, 268N, 269V, 270K, 271K, 272A, 273L, 284V, 285D, 286A, 287G, 288A, 289L, 290F, 291I, 292G, 293K, 294L, 295K, 296G, 297V, 298T, 299D, 300P, 301E, 302K, 303K, 304R, 305K, 306I, 307I, 308G, 309N, 310T, 311F, 312I, 313E, 314V, 315F, 316E, 317E, 318E, 319A, 320A, 321K, 332F, 333L, 334L, 335Q, 336G, 337T, 338L, 339Y, 340P, 341D, 342V, 343I, 344E, 345S, 346I, 347S, 356K, 357T, 358H, 359H, 360N, 361V, 362G, 363G, 364L, 365L, 370L, 371K, 372L, 373I, 374E, 375P, 376L, 377R, 378E, 379L, 380F, 381K, 382D, 383E, 384V, 385R, 386K, 387L, 388G, 389E, 390L, 391L, 392E, 393V, 394P, 400R, 401H, 402P, 403F, 404P, 405G, 406P, 407G, 408L, 409A, 410I, 411R, 412I, 413L, 414G
CDD
cd01997 (GMP_synthase_C)
Ligand Binding sit...

229A

Ligand Binding sites
229A, 230V, 231S, 233G, 234V, 235D, 236S, 254I, 256V, 381K
CDD
cd01997 (GMP_synthase_C)

230V

Ligand Binding sites
229A, 230V, 231S, 233G, 234V, 235D, 236S, 254I, 256V, 381K
CDD
cd01997 (GMP_synthase_C)

231S

Ligand Binding sites
229A, 230V, 231S, 233G, 234V, 235D, 236S, 254I, 256V, 381K
CDD
cd01997 (GMP_synthase_C)

233G

Ligand Binding sites
229A, 230V, 231S, 233G, 234V, 235D, 236S, 254I, 256V, 381K
CDD
cd01997 (GMP_synthase_C)

234V

Ligand Binding sites
229A, 230V, 231S, 233G, 234V, 235D, 236S, 254I, 256V, 381K
CDD
cd01997 (GMP_synthase_C)

235D

Ligand Binding sites
229A, 230V, 231S, 233G, 234V, 235D, 236S, 254I, 256V, 381K
CDD
cd01997 (GMP_synthase_C)

236S

Ligand Binding sites
229A, 230V, 231S, 233G, 234V, 235D, 236S, 254I, 256V, 381K
CDD
cd01997 (GMP_synthase_C)

254I

Ligand Binding sites
229A, 230V, 231S, 233G, 234V, 235D, 236S, 254I, 256V, 381K
CDD
cd01997 (GMP_synthase_C)

256V

Ligand Binding sites
229A, 230V, 231S, 233G, 234V, 235D, 236S, 254I, 256V, 381K
CDD
cd01997 (GMP_synthase_C)

381K

Ligand Binding sites
229A, 230V, 231S, 233G, 234V, 235D, 236S, 254I, 256V, 381K
CDD
cd01997 (GMP_synthase_C)
Dimerization subdo...

423I

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

424A

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

425R

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

426K

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

427A

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

428D

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

429H

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

430I

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

431F

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

432I

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

433E

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

434E

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

435I

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

444I

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

445S

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

446Q

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

447A

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

448F

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

449A

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

450C

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

451L

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

452L

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

453P

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

456S

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

457V

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

458G

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

459V

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

460M

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

461G

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

462D

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

463Q

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

464R

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

465T

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

466Y

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

470I

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

471A

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

472L

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

473R

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

474A

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

475I

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

476E

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

477T

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

478T

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

479D

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

480F

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

481M

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

482T

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

483A

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

484D

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

485W

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

492F

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

493L

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

494K

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

495N

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

496V

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

497S

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

498K

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

499R

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

500I

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

502N

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

503E

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

504V

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

505Q

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

506G

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

507V

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

508A

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

509R

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

510V

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

511T

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

512Y

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

513D

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

514I

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

515T

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

516S

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

517K

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

518P

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

519P

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

520A

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

521T

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

522V

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

523E

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

524W

Dimerization subdomain
423I, 424A, 425R, 426K, 427A, 428D, 429H, 430I, 431F, 432I, 433E, 434E, 435I, 444I, 445S, 446Q, 447A, 448F, 449A, 450C, 451L, 452L, 453P, 456S, 457V, 458G, 459V, 460M, 461G, 462D, 463Q, 464R, 465T, 466Y, 470I, 471A, 472L, 473R, 474A, 475I, 476E, 477T, 478T, 479D, 480F, 481M, 482T, 483A, 484D, 485W, 492F, 493L, 494K, 495N, 496V, 497S, 498K, 499R, 500I, 502N, 503E, 504V, 505Q, 506G, 507V, 508A, 509R, 510V, 511T, 512Y, 513D, 514I, 515T, 516S, 517K, 518P, 519P, 520A, 521T, 522V, 523E, 524W
CDD
cd01997 (GMP_synthase_C)

Protein sequence

>MCA_05222_1
MTKPVEVSNVFDTILVLDFGSQYSHLITRRLREFNVYAEMLPCTQKIAELTWKPKGIILSGGPYSVYAEGSPHVDHAIFD
LGVPILGICYGMQELAWINGKGVSAADHREYGNATIEVQDPTCPLFADIDHFQVWMSHGDKLSALPTGYKVVATTSNSPY
AAIAHETSQIYGIQFHPEVTHTTKGKQLLKNFAVDICKAEQKWSMENFIGTEIERIRALVGPTAEVIGAVSGGVDSTVAS
AIMKRAIGDRFHAIYVDNGLMRLYETENVKKALDDGLGINLTVVDAGALFIGKLKGVTDPEKKRKIIGNTFIEVFEEEAA
KITPKSGDEIEFLLQGTLYPDVIESISFKGPSQTIKTHHNVGGLLENMKLKLIEPLRELFKDEVRKLGELLEVPSELVWR
HPFPGPGLAIRILGEITESQLEIARKADHIFIEEIRKAGIYNEISQAFACLLPVRSVGVMGDQRTYEQVIALRAIETTDF
MTADWYVFEAAFLKNVSKRIVNEVQGVARVTYDITSKPPATVEWE

GO term prediction

Biological Process

GO:0006164 purine nucleotide biosynthetic process
GO:0006177 GMP biosynthetic process

Molecular Function

GO:0003922 GMP synthase (glutamine-hydrolyzing) activity
GO:0005524 ATP binding
GO:0016462 pyrophosphatase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features