Protein

MCA_05198_2

Length
437 amino acids

Gene name: IDP1

Description: Isocitrate dehydrogenase [NADP], mitochondrial

Browser: contigD:602559-605517-

RNA-seq: read pairs 30976, FPKM 873.8, percentile rank 96.3% (100% = highest expression)

Protein function

Annotation:IDP1Isocitrate dehydrogenase [NADP], mitochondrial
KEGG:K00031IDH1 isocitrate dehydrogenase [EC:1.1.1.42]
EGGNOG:0PFHRIDP1isocitrate dehydrogenase NADP
SGD closest match:S000002224IDP1Isocitrate dehydrogenase [NADP], mitochondrial
CGD closest match:CAL0000198913IDP2Isocitrate dehydrogenase [NADP]

Protein alignments

%idAln lengthE-value
MIA_01691_187.35%4110.0MIA_01691_1
A0A0J9X2J0_GEOCN82.23%4390.0Isocitrate dehydrogenase [NADP] OS=Geotrichum candidum GN=BN980_GECA01s02419g PE=3 SV=1
A0A167DAF2_9ASCO82.52%4120.0Isocitrate dehydrogenase [NADP] OS=Sugiyamaella lignohabitans GN=IDP2 PE=3 SV=1
A0A1E3PR45_9ASCO81.11%4130.0Isocitrate dehydrogenase [NADP] OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_44604 PE=3 SV=1
A0A060SY52_BLAAD82.47%4050.0Isocitrate dehydrogenase [NADP] OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A18040g PE=3 SV=1
Q6C2Y4_YARLI80.82%4170.0Isocitrate dehydrogenase [NADP] OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F04095g PE=3 SV=2
UniRef50_K0KYI175.29%4370.0Isocitrate dehydrogenase [NADP] n=252 Tax=Eukaryota TaxID=2759 RepID=K0KYI1_WICCF
A0A1E4TKX1_9ASCO84.22%3930.0Isocitrate dehydrogenase [NADP] OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_993 PE=3 SV=1
A0A1D8PS79_CANAL79.36%4070.0Isocitrate dehydrogenase [NADP] OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=IDP2 PE=3 SV=1
IDHP_YEAST77.07%4100.0Isocitrate dehydrogenase [NADP], mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=IDP1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9555
Predicted cleavage: 27

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 437

Detailed signature matches

  1. Family IPR004790
    Isocitrate dehydrogenase NADP-dependent
    1. TIGR00127
    2. PIRSF000108 (IDH_NADP)
  2. Domain IPR024084
    Isopropylmalate dehydrogenase-like domain
    1. SM01329 (Iso_dh_2)
    2. PF00180 (Iso_dh)
  3. SITE IPR019818
    Isocitrate/isopropylmalate dehydrogenase, conserved site
    1. PS00470 (IDH_IMDH)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.71...
  2. SSF53659 (Isocitrat...)

Protein sequence

>MCA_05198_2
MAQFRRLSQLASQMAVPALNRTQARYASTFEKIKVKNPIVELDGDEMTRIIWKSIKDKLITPFLDVDLKYYDLGIEYRDQ
TDDKVTVDAAEAILKYQVGVKCATITPDEARVEEFKLKKMWLSPNGTIRNILGGTVFREPIVIPRIPRLVPGWEKPIIIG
RHAHGDQYKAADTVIPGAGKVELVYHPAEGGEPQKLQLFDYKGAGVAMAMYNTDESIEGFAHASFKMALDKGLNLFMSTK
NTILKRYDGRFKDIFQDLYDNQYKPQFEAKGIWYEHRLIDDMVAQMIKSKGGYIIAMKNYDGDVQSDIVAQGFGSLGLMT
SVLISPDGKTFESEAAHGTVTRHYRQHQQGKETSTNSIASIYAWTRGIAQRGKLDETPDVVKFAEAVEKATIDTVQVDGI
MTKDLALACGNTDRSSYVLTEEFIDAVAARLRKELGA

GO term prediction

Biological Process

GO:0006102 isocitrate metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0000287 magnesium ion binding
GO:0004450 isocitrate dehydrogenase (NADP+) activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding

Cellular Component

None predicted.