Protein
MCA_05166_1
Length
380 amino acids
Gene name: LYS12
Description: Homoisocitrate dehydrogenase, mitochondrial
Browser: contigD:513551-514694-
RNA-seq: read pairs 2989, FPKM 96.9, percentile rank 78.2% (100% = highest expression)
Protein function
| Annotation: | LYS12 | Homoisocitrate dehydrogenase, mitochondrial | |
|---|---|---|---|
| KEGG: | K05824 | LYS12 | homoisocitrate dehydrogenase [EC:1.1.1.87] |
| EGGNOG: | 0PHTX | LYS12 | Homo-isocitrate dehydrogenase |
| SGD closest match: | S000001356 | LYS12 | Homoisocitrate dehydrogenase, mitochondrial |
| CGD closest match: | CAL0000198832 | LYS12 | Homoisocitrate dehydrogenase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_00383_1 | 88.42% | 380 | 0.0 | MIA_00383_1 |
| A0A0J9XES5_GEOCN | 78.48% | 381 | 0.0 | Similar to Saccharomyces cerevisiae YIL094C LYS12 Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine OS=Geotrichum candidum GN=BN980_GECA12s03739g PE=4 SV=1 |
| A0A060TC65_BLAAD | 76.86% | 363 | 0.0 | ARAD1B20812p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B20812g PE=4 SV=1 |
| Q5A9D9_CANAL | 76.22% | 370 | 0.0 | Homoisocitrate dehydrogenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=LYS12 PE=4 SV=1 |
| A0A1E3PDM7_9ASCO | 72.63% | 380 | 0.0 | Homoisocitrate dehydrogenase mitochondrial OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47927 PE=4 SV=1 |
| A0A1E4TJA1_9ASCO | 72.85% | 372 | 0.0 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_379 PE=4 SV=1 |
| UniRef50_A0A1E3NYI3 | 69.45% | 383 | 2e-179 | Uncharacterized protein n=1 Tax=Wickerhamomyces anomalus NRRL Y-366-8 TaxID=683960 RepID=A0A1E3NYI3_WICAO |
| Q6C9K0_YARLI | 72.75% | 367 | 0.0 | YALI0D10593p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D10593g PE=4 SV=1 |
| LYS12_YEAST | 67.72% | 381 | 0.0 | Homoisocitrate dehydrogenase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LYS12 PE=1 SV=1 |
| A0A161HFA2_9ASCO | 71.68% | 279 | 1e-141 | Homoisocitrate dehydrogenase OS=Sugiyamaella lignohabitans GN=LYS12 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.9757
Predicted cleavage: 20
Protein family membership
None predicted.
Domains and repeats
-
Domain
1
50
100
150
200
250
300
350
380
Detailed signature matches
-
-
PS00470 (IDH_IMDH)
-
no IPR
Unintegrated signatures
-
-
SSF53659 (Isocitrat...)
Protein sequence
>MCA_05166_1 MLRSNITRRLNSGVLARAYSTQSKTLKIGLIPGDGIGREVIPAGKAVLEALPKEDGLKFEFVNLLAGFEHFKKHGTALPD ETVEVLKSECNGALFGAVSSPTTKVAGYSSPIVALRKKMGLYANVRPVKSVDGAPGRPVDLVIVRENTEDLYIKQEKLYT AEDGTQVAEAIKRITETASKNIGKMAFDIALSRQALRDAGAPSIHKNSTVTITHKSNVLSLSDGLFRESVRKVFEENKDK YAAVNVNEQIVDSMVYRLFREPEAFDVVVGPNLYGDILSDGAAALVGSLGVVPSANVGDSFVIGEPCHGSAPDIEGKGIA NPVATIRSTALMLEFLGFPEPAARIYKAVDANLAEGKILTPDLGGKSSTQEVIDDIVSKM
GO term prediction
Biological Process
GO:0055114 oxidation-reduction process
Molecular Function
GO:0000287 magnesium ion binding
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding
Cellular Component
None predicted.