Protein

MCA_05070_1

Length
1,081 amino acids

Gene name: CRM1

Description: Exportin-1

Browser: contigD:286500-290018+

RNA-seq: read pairs 6348, FPKM 72.5, percentile rank 73.4% (100% = highest expression)

Protein function

Annotation:CRM1Exportin-1
KEGG:K14290XPO1 exportin-1
EGGNOG:0PI0KCRM1exportin-1
SGD closest match:S000003450CRM1Exportin-1
CGD closest match:CAL0000197974CRM1Exportin

Protein alignments

%idAln lengthE-value
MIA_05421_179.00%10810.0MIA_05421_1
A0A0J9X7P6_GEOCN70.52%10820.0Similar to Saccharomyces cerevisiae YGR218W CRM1 Major karyopherin OS=Geotrichum candidum GN=BN980_GECA04s05752g PE=4 SV=1
A0A060T4K5_BLAAD67.56%10790.0ARAD1B00286p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B00286g PE=4 SV=1
A0A1E3PEU4_9ASCO64.20%10950.0Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_52886 PE=4 SV=1
A0A161HHX7_9ASCO66.12%9830.0Exportin CRM1 OS=Sugiyamaella lignohabitans GN=CRM1 PE=4 SV=1
Q6C278_YARLI58.61%10800.0YALI0F10098p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F10098g PE=4 SV=2
A0A1E4TIK3_9ASCO58.47%10860.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_72949 PE=4 SV=1
UniRef50_A0A1X7R9P457.66%10840.0Similar to Saccharomyces cerevisiae YGR218W CRM1 Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus n=1 Tax=Kazachstania saulgeensis TaxID=1789683 RepID=A0A1X7R9P4_9SACH
XPO1_YEAST57.55%10860.0Exportin-1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CRM1 PE=1 SV=1
A0A1D8PRR9_CANAL57.92%10860.0Exportin OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CRM1 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.4312

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 700 800 900 1000 1081

Detailed signature matches

  1. Domain IPR016024
    Armadillo-type fold
    1. SSF48371 (ARM repeat)
  2. Domain IPR011989
    Armadillo-like helical
    1. G3DSA:1.25.10.10
  3. Domain IPR001494
    Importin-beta, N-terminal domain
    1. SM00913 (IBN_N_2)
    2. PS50166 (IMPORTIN_B_NT)
    3. PF03810 (IBN_N)
  4. Domain IPR013598
    Exportin-1/Importin-beta-like
    1. PF08389 (Xpo1)
  5. Domain IPR014877
    CRM1 C-terminal domain
    1. PF08767 (CRM1_C)
    2. SM01102 (CRM1_C_2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil

Protein sequence

>MCA_05070_1
MEQLLDFSKDVDTDLLDRIVTVFFSGQGSAAERSEADSVLKRFQDHPDSWTRAPTILQQSKNPQSKYIALSVLDKLITTR
WKALPENERQGIRNFVVGLCVNWSNDDEVFRTQKSLINKANITLVQILKMEWPTHWPTFIPDILSSSRSSANVCENNMTI
LKLLSEEVFDFSAEQMTSTKARNLKSQLKQEFSEIFNLCIEVLQNADRPSLIKATLQSLLRYINWIDHAYLFETPLTVLL
VSKFLTPPETRNVTLKCLTEISALHNPQKNVVLRDMFTNSIAILKEIVPPSTNFKDVYDNASSLDQEFIQDLALFLSTFF
TNHLRLIEENDDKTLLIESHTYLINISRIEEREVFKIALDYWARLVQDLFNEINQIPLSDMNPAFGRQVLNRYTSGGATN
PDILANYPLRKHIYSSILSQLRVVMIEKMVRPEEVLVVENDEGEIVREFVKESDTITLYKSIREVLVYLTHLDVNDTENI
MREKLAKQSDGTEWSWNNINTLCWAIGSISGAMDEEMEKHFLVYVIRELLTLTEQKQGKDNKAVVASNIMYIVGQYPRFL
RAHWRFLKTVVNKLFEFMHETHDGVQDMACDTFIKIAQKCKKQFVTLQAGETEPFIDEILRTLNDITSDLQPQQVQTFYE
ACGYIIVAQPSKEIKEKLLGDLMKLPNVAWGGILQQSRTDPELLTNPETIKIIANIMKTNVATCLAVGAAFAPQLGFIYM
DMLSLYKAVSSMISQAVAEQGAIATKTPRVRGLRTIKKEILKLIEAFVSKAVDLEHVCTDMVPGLLQAVLDDYRTNLPDA
REAEVLHCMDTLVSRVGKLVPDMVLSVLEHVFECTLEMINKSMNDYPEHRVEFFKLLRTINLTSFPALLKLPDPVFKQTV
DACLWGAKHDNRDVESSGLSLLSELITNIGDLNNEISNVFFQRFFKPIIADTFYVLTDSDHKAGFKTQTEILSKIIELLN
TGRITAPIYEPGEAPENTSNIDYFKEYMTNLLISAFPHLQRAKVAAFLSNLVRDYSDPAKFKTTLRDFLVEIKEFDGEDT
EYLFAEDKKNELESKQQVEMERAKKIGGLIKPSDMIEDDDI

GO term prediction

Biological Process

GO:0006886 intracellular protein transport

Molecular Function

GO:0005488 binding
GO:0008536 Ran GTPase binding

Cellular Component

None predicted.