Protein

MCA_05034_1

Length
343 amino acids

Gene name: HEM2

Description: Delta-aminolevulinic acid dehydratase

Browser: contigD:187203-188311-

RNA-seq: read pairs 3088, FPKM 110.9, percentile rank 80.4% (100% = highest expression)

Protein function

Annotation:HEM2Delta-aminolevulinic acid dehydratase
KEGG:K01698hemB porphobilinogen synthase [EC:4.2.1.24]
EGGNOG:0PFRXHEM2delta-aminolevulinic acid dehydratase
SGD closest match:S000003008HEM2Delta-aminolevulinic acid dehydratase
CGD closest match:CAL0000184061HEM2Delta-aminolevulinic acid dehydratase

Protein alignments

%idAln lengthE-value
MIA_04830_188.56%3410.0MIA_04830_1
A0A0J9XEZ9_GEOCN84.62%3380.0Delta-aminolevulinic acid dehydratase OS=Geotrichum candidum GN=BN980_GECA12s02837g PE=3 SV=1
A0A1E3PRC9_9ASCO79.06%3392e-177Delta-aminolevulinic acid dehydratase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_80997 PE=3 SV=1
A0A060SY48_BLAAD76.88%3463e-176ARAD1A17930p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A17930g PE=3 SV=1
Q6C0Y3_YARLI76.40%3394e-175Delta-aminolevulinic acid dehydratase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F20790g PE=3 SV=1
A0A1D8PGU4_CANAL75.67%3374e-173Delta-aminolevulinic acid dehydratase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HEM2 PE=3 SV=1
A0A161HIP3_9ASCO85.00%3004e-170Porphobilinogen synthase HEM2 OS=Sugiyamaella lignohabitans GN=HEM2 PE=3 SV=1
HEM2_YEAST72.78%3383e-160Delta-aminolevulinic acid dehydratase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HEM2 PE=1 SV=2
UniRef50_P0537372.78%3387e-157Delta-aminolevulinic acid dehydratase n=360 Tax=Eukaryota TaxID=2759 RepID=HEM2_YEAST
A0A1E4TIM7_9ASCO66.07%3364e-147Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_73113 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1181

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 343

Detailed signature matches

  1. Family IPR001731
    Delta-aminolevulinic acid dehydratase
    1. PF00490 (ALAD)
    2. PIRSF001415 (Porphb...)
    3. SM01004 (ALAD_2)
    4. PR00144 (DALDHYDRTASE)
  2. Domain IPR013785
    Aldolase-type TIM barrel
    1. G3DSA:3.20.20.70
  3. SITE IPR030656
    Delta-aminolevulinic acid dehydratase, active site
    1. PS00169 (D_ALA_DEHY...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. SSF51569 (Aldolase)

Protein sequence

>MCA_05034_1
MSERHTAQYTKGLPTDHSSLLAGGYNHPLAREWQMKTQLTKNMFIYPLFITDDPDAEEEIASLPNQKRWGVNKLVPFVKT
LVEKGLRSVILFGVPMKEGVKDEVGSAADDPNGPVILGIKALRENFPDLFIMCDVCLCEYTSHGHCGVLREDGSIIREQS
VKRLAAVAVNYAKAGAHAVAPSDMIDGRIRDIKQGLLEADLAHKTMIMSYAAKFSGNLYGPFREAAGSCPSHGDRKAYQL
PPGGRGLARRALTRDINEGADAIIVKPSTFYLDIVSDAAEICRDYPIATYQVSGEFAMLHAAAEKGIVDLKTIAYEAAYG
SIRAGANLLISYFTPEFLNWLDN

GO term prediction

Biological Process

GO:0033014 tetrapyrrole biosynthetic process

Molecular Function

GO:0003824 catalytic activity
GO:0004655 porphobilinogen synthase activity
GO:0046872 metal ion binding

Cellular Component

None predicted.