Protein

MCA_04999_1

Length
406 amino acids

Gene name: GCV1

Description: Aminomethyltransferase, mitochondrial

Browser: contigD:58574-59795+

RNA-seq: read pairs 4568, FPKM 138.7, percentile rank 83.9% (100% = highest expression)

Protein function

Annotation:GCV1Aminomethyltransferase, mitochondrial
KEGG:K00605gcvT aminomethyltransferase [EC:2.1.2.10]
EGGNOG:0PFBYGCV1The glycine cleavage system catalyzes the degradation of glycine (By similarity)
SGD closest match:S000002426GCV1Aminomethyltransferase, mitochondrial
CGD closest match:CAL0000177615GCV1Aminomethyltransferase

Protein alignments

%idAln lengthE-value
MIA_04724_175.42%4150.0MIA_04724_1
A0A0J9XG40_GEOCN70.17%4090.0Aminomethyltransferase OS=Geotrichum candidum GN=BN980_GECA14s01583g PE=3 SV=1
A0A167DUB8_9ASCO63.25%4004e-179Aminomethyltransferase OS=Sugiyamaella lignohabitans GN=GCV1 PE=3 SV=1
A0A060T8W2_BLAAD59.75%4054e-168Aminomethyltransferase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C32868g PE=3 SV=1
Q6C340_YARLI58.65%3992e-164Aminomethyltransferase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F02849g PE=3 SV=1
A0A1E3PPF9_9ASCO58.87%3892e-160Aminomethyltransferase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_73221 PE=3 SV=1
A0A1D8PPW9_CANAL57.18%3901e-156Aminomethyltransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=GCV1 PE=3 SV=1
UniRef50_A3LT7754.94%3952e-150Aminomethyltransferase n=8 Tax=Saccharomycetales TaxID=4892 RepID=A3LT77_PICST
GCST_YEAST53.69%4061e-129Aminomethyltransferase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GCV1 PE=1 SV=2
A0A1E4TFG0_9ASCO48.28%4081e-126Aminomethyltransferase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2238 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9955
Predicted cleavage: 20

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 406

Detailed signature matches

  1. Family IPR006223
    Glycine cleavage system T protein
    1. TIGR00528
  2. Domain IPR006222
    Glycine cleavage T-protein-like, N-terminal
    1. PF01571 (GCV_T)
  3. Domain IPR029043
    Glycine cleavage T-protein/YgfZ, C-terminal domain
    1. SSF101790 (Aminomet...)
  4. Domain IPR013977
    Glycine cleavage T-protein, C-terminal barrel domain
    1. G3DSA:2.40.30...
    2. PF08669 (GCV_T_C)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.30.13...
  2. G3DSA:4.10.12...
  3. PIRSF006487 (GCST)
  4. SSF103025 (Folate-b...)

Protein sequence

>MCA_04999_1
MLRTIVRKPTAVAPILKRFNSSSTENLLKTPFYDLHLELGGTMVPYAGFSMPVLYKSQSHIESHNWVRSKAGLFDVSHML
QHKIQGPKSTEFLEKITPSDLKSLEPFSSTLSVILNSNGGVVDDTIITKHGEDEFYVVTNAGCREKDLKFIGEELQNFQQ
VSRSDITGGLLAFQGPEAAPILQKLTTYDLNTLKFGHSAFIPLSIGGDKYHVARGGYTGEDGFEISIPDEVKANEFARIL
LNDFPDTVRAIGLAARDSLRLEAGMCLYGHELSEEITPVEAGLTWVIGKNRRDPATAGFNGAEKILAQVADKSLVKKVRR
GITVKGPAARENMDVYTGDSTSVDAGTKIGVVTSGSFSPSTKQNIGMVYVPRKYMKVGTELKVNVRGKLREAKIAKMPFI
EPNYFR

GO term prediction

Biological Process

GO:0006546 glycine catabolic process

Molecular Function

GO:0004047 aminomethyltransferase activity

Cellular Component

None predicted.