Protein

MCA_04963_1

Length
712 amino acids

Gene name: HAS1

Description: ATP-dependent RNA helicase HAS1

Browser: contigC:4528027-4530166-

RNA-seq: read pairs 2381, FPKM 41.3, percentile rank 60.9% (100% = highest expression)

Protein function

Annotation:HAS1ATP-dependent RNA helicase HAS1
KEGG:K13179DDX18 ATP-dependent RNA helicase DDX18/HAS1 [EC:3.6.4.13]
EGGNOG:0PH4UHAS1ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA
SGD closest match:S000004903HAS1ATP-dependent RNA helicase HAS1
CGD closest match:CAL0000175982HAS1ATP-dependent RNA helicase HAS1

Protein alignments

%idAln lengthE-value
MIA_03751_186.45%4650.0MIA_03751_1
A0A0J9X537_GEOCN80.99%4630.0RNA helicase OS=Geotrichum candidum GN=BN980_GECA03s03618g PE=3 SV=1
A0A167EDR9_9ASCO80.22%4600.0RNA helicase OS=Sugiyamaella lignohabitans GN=HAS1 PE=3 SV=1
UniRef50_G0W8A978.74%4610.0RNA helicase n=38 Tax=Eukaryota TaxID=2759 RepID=G0W8A9_NAUDC
HAS1_YEAST80.49%4510.0ATP-dependent RNA helicase HAS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HAS1 PE=1 SV=1
HAS1_YARLI78.02%4640.0ATP-dependent RNA helicase HAS1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=HAS1 PE=3 SV=1
A0A060TDJ0_BLAAD76.48%4550.0RNA helicase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D07238g PE=3 SV=1
A0A1E4TJV7_9ASCO75.91%4690.0RNA helicase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_55755 PE=3 SV=1
HAS1_CANAL77.68%4570.0ATP-dependent RNA helicase HAS1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HAS1 PE=3 SV=1
A0A1E3PRE1_9ASCO84.91%2856e-166p-loop containing nucleoside triphosphate hydrolase protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_80972 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.3472

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 100 200 300 400 500 600 712

Detailed signature matches

  1. Domain IPR014014
    RNA helicase, DEAD-box type, Q motif
    1. PS51195 (Q_MOTIF)
  2. Domain IPR014001
    Helicase superfamily 1/2, ATP-binding domain
    1. PS51192 (HELICASE_A...)
    2. SM00487 (ultradead3)
  3. Domain IPR011545
    DEAD/DEAH box helicase domain
    1. PF00270 (DEAD)
  4. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  5. Domain IPR001650
    Helicase, C-terminal
    1. PS51194 (HELICASE_CTER)
    2. SM00490 (helicmild6)
    3. PF00271 (Helicase_C)
  6. Domain IPR025313
    Domain of unknown function DUF4217
    1. SM01178 (DUF4217_3)
    2. PF13959 (DUF4217)
  7. SITE IPR000629
    ATP-dependent RNA helicase DEAD-box, conserved site
    1. PS00039 (DEAD_ATP_H...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:3.40.50...
  3. cd00079 (HELICc)
  4. cd00268 (DEADc)
  5. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. Mg++ binding site ...
  3. motif III cd00268
  4. nucleotide binding...
  5. ATP-binding site c...

Protein sequence

>MCA_04963_1
MGSKINIKAPGKGKSYRAKDFKKPGISKTKVIKKSGKTKHLKIIPPPSEALESSKILSTISDQYDNLTESTNDGKNNNAS
VKSVSEGVDQIRDLLNGSNTAASSFDNQESLVLMKNGSKIAAKYSSASESLSDQKDSSRNEKDYDESEDESEDEDENENE
DEDEDEDEDEDEDEDNDESKIEIEEEDKEEGSGRNEKKSYTNSQKNDLESLDGSFDSTKDKESTTGEKDPVYFRDLNISA
PTLQALESFGFEKMTKVQANTIPPLLAGRDVLGAAKTGSGKTLAFLIPSVELLYSLKFKPRNGTGVIIVSPTRELAIQIF
KVARDLMANHSQTVGLVIGGEKIHTEQESLRKGINLLVATPGRLLDHLLNAKGFIFKNLKALIVDEADRVLNIGFEETMK
QIVRILPKEGRQTMLFSATQTTKVEDLARISLKKGPLYINVDEEKETSTADGLEQGYVVCDSDKRFLLLFSFLKRNLKKK
VIVFLSSCNSVKYYGELLNYIDLPVLDLHGKQKQQKRTNTFFEFCNAKTGILICTDVAARGLDIPQVDWIIQFDPPDDPK
DYIHRVGRTARGTNGKGRSLMFLTPSELGFLRYLKANKVPLNEYEFPANKIANIQSQLEKLVSSNYLLNQSAREGYKSYL
QAYASHSTKSVYQIDKLDLTKVAKSYGFSVPPKVNITLGVSGKGKRQATQDDTSKLANKKKKTNKDSSKWTR

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003676 nucleic acid binding
GO:0005524 ATP binding

Cellular Component

None predicted.