Protein

MCA_04857_1

Length
368 amino acids

Gene name: HEM12

Description: Uroporphyrinogen decarboxylase

Browser: contigC:4263140-4264482-

RNA-seq: read pairs 3358, FPKM 112.4, percentile rank 80.6% (100% = highest expression)

Protein function

Annotation:HEM12Uroporphyrinogen decarboxylase
KEGG:K01599hemE uroporphyrinogen decarboxylase [EC:4.1.1.37]
EGGNOG:0PGWWHEM12Uroporphyrinogen decarboxylase
SGD closest match:S000002454HEM12Uroporphyrinogen decarboxylase
CGD closest match:CAL0000200987orf19.5369Uroporphyrinogen decarboxylase

Protein alignments

%idAln lengthE-value
A0A0J9X2T0_GEOCN81.37%3650.0Uroporphyrinogen decarboxylase OS=Geotrichum candidum GN=BN980_GECA01s09877g PE=3 SV=1
MIA_03415_178.42%3660.0MIA_03415_1
A0A060T3K9_BLAAD76.31%3630.0Uroporphyrinogen decarboxylase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C34562g PE=3 SV=1
Q5A5N0_CANAL73.06%3600.0Uroporphyrinogen decarboxylase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.5369 PE=3 SV=1
DCUP_YEAST69.97%3630.0Uroporphyrinogen decarboxylase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HEM12 PE=1 SV=1
UniRef50_P3234769.97%3630.0Uroporphyrinogen decarboxylase n=637 Tax=Eukaryota TaxID=2759 RepID=DCUP_YEAST
Q6CDC5_YARLI66.04%3716e-180Uroporphyrinogen decarboxylase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C01716g PE=3 SV=1
A0A1E3PNU6_9ASCO64.69%3714e-174Uroporphyrinogen decarboxylase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45312 PE=4 SV=1
A0A1E4TDY0_9ASCO60.66%3611e-156Uroporphyrinogen decarboxylase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_96986 PE=3 SV=1
A0A167FBT4_9ASCO74.26%2723e-147Uroporphyrinogen decarboxylase HEM12 OS=Sugiyamaella lignohabitans GN=HEM12 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0303

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 368

Detailed signature matches

  1. Family IPR006361
    Uroporphyrinogen decarboxylase HemE
    1. TIGR01464
    2. MF_00218 (URO_D)
    3. cd00717 (URO-D)
  2. Domain IPR000257
    Uroporphyrinogen decarboxylase (URO-D)
    1. PS00906 (UROD_1)
    2. PS00907 (UROD_2)
    3. PF01208 (URO-D)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.20.20...
  2. SSF51726 (UROD/MetE...)

Residue annotation

  1. substrate binding ...
  2. active site cd00717

Protein sequence

>MCA_04857_1
MTNAHIDKFPPLKNDLILRAARGEKVERPPVWMMRQAGRYLPEYHKVKGNRDFFEVCRDAEIASEITIQPVDHFDGLIDA
AIIFSDILVIPQAMGMDVEIREKTGPYFPDPLRVPDVDIDRLLQKDVDVTKSLDWAFRAITLTRKKLNGRVPLLGFCGGP
FTLLVYMTEGGSTKLYRYIRTWIYKYPEQSKHVLQRITDVAVEFLAQQVVAGAQMLQVFESWAGELGPKEFREFSLPYLK
QIAAKLPLRLKELGVEEKIPVTIFAKGAWYALDELCDSGYDAVSLDWLYDPEEAVKVNKGRVTLQGNLDPGIIYGSKEII
SKKVEEMIKGFQGGKQHYIVNLGHGTQPFMDPENVEWFLKECHRFGSQ

GO term prediction

Biological Process

GO:0006779 porphyrin-containing compound biosynthetic process

Molecular Function

GO:0004853 uroporphyrinogen decarboxylase activity

Cellular Component

None predicted.