Protein

MCA_04835_1

Length
2,253 amino acids

Gene name: ACC1

Description: Acetyl-CoA carboxylase

Browser: contigC:4204151-4211008-

RNA-seq: read pairs 40988, FPKM 224.7, percentile rank 89.4% (100% = highest expression)

Protein function

Annotation:ACC1Acetyl-CoA carboxylase
KEGG:K11262ACACA acetyl-CoA carboxylase / biotin carboxylase 1 [EC:6.4.1.2 6.3.4.14]
EGGNOG:0PH59ACC1acetyl-CoA carboxylase
SGD closest match:S000005299ACC1Acetyl-CoA carboxylase
CGD closest match:CAL0000198598ACC1Acetyl-CoA carboxylase

Protein alignments

%idAln lengthE-value
MIA_04843_187.79%22360.0MIA_04843_1
A0A0J9XGW0_GEOCN79.88%22370.0Similar to Saccharomyces cerevisiae YNR016C ACC1 Acetyl-CoA carboxylase OS=Geotrichum candidum GN=BN980_GECA16s00978g PE=4 SV=1
A0A060T7V3_BLAAD74.16%22410.0ARAD1D05412p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D05412g PE=4 SV=1
A0A1E3PP51_9ASCO73.45%22410.0Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49644 PE=4 SV=1
A0A167BXZ4_9ASCO75.06%21810.0Acetyl-CoA carboxylase ACC1 OS=Sugiyamaella lignohabitans GN=ACC1 PE=4 SV=1
Q6CC91_YARLI71.04%22510.0YALI0C11407p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C11407g PE=4 SV=1
UniRef50_K0KVW069.75%22380.0Acetyl-CoA carboxylase, putative n=103 Tax=Dikarya TaxID=451864 RepID=K0KVW0_WICCF
A0A1D8PRR7_CANAL67.81%22370.0Acetyl-CoA carboxylase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ACC1 PE=4 SV=1
ACAC_YEAST67.11%22380.0Acetyl-CoA carboxylase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ACC1 PE=1 SV=2
A0A1E4TFM8_9ASCO62.22%22500.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2313 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0518

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 500 1000 1500 2000 2253

Detailed signature matches

  1. Domain IPR016185
    Pre-ATP-grasp domain
    1. SSF52440 (PreATP-gr...)
  2. Domain IPR011764
    Biotin carboxylation domain
    1. PS50979 (BC)
  3. Domain IPR005481
    Biotin carboxylase-like, N-terminal domain
    1. PF00289 (Biotin_carb_N)
  4. Domain IPR011761
    ATP-grasp fold
    1. PS50975 (ATP_GRASP)
  5. Domain IPR013815
    ATP-grasp fold, subdomain 1
    1. G3DSA:3.30.14...
  6. Domain IPR005479
    Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
    1. PF02786 (CPSase_L_D2)
    2. PS00867 (CPSASE_2)
    3. PS00866 (CPSASE_1)
  7. Domain IPR011054
    Rudiment single hybrid motif
    1. SSF51246 (Rudiment ...)
  8. Domain IPR005482
    Biotin carboxylase, C-terminal
    1. SM00878 (Biotin_car...)
    2. PF02785 (Biotin_carb_C)
  9. Domain IPR011053
    Single hybrid motif
    1. SSF51230 (Single hy...)
  10. Domain IPR000089
    Biotin/lipoyl attachment
    1. PS50968 (BIOTINYL_L...)
    2. PF00364 (Biotin_lipoyl)
  11. Domain IPR013537
    Acetyl-CoA carboxylase, central domain
    1. PF08326 (ACC_central)
  12. Domain IPR029045
    ClpP/crotonase-like domain
    1. SSF52096 (ClpP/crot...)
  13. Domain IPR011762
    Acetyl-coenzyme A carboxyltransferase, N-terminal
    1. PS50980 (COA_CT_NTER)
  14. Domain IPR034733
    Acetyl-CoA carboxylase
    1. PF01039 (Carboxyl_t...)
  15. Domain IPR011763
    Acetyl-coenzyme A carboxyltransferase, C-terminal
    1. PS50989 (COA_CT_CTER)
  16. SITE IPR001882
    Biotin-binding site
    1. PS00188 (BIOTIN)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:2.40.50...
  3. G3DSA:3.30.47...
  4. G3DSA:3.40.50.20
  5. G3DSA:3.90.17...
  6. G3DSA:3.90.22...
  7. SSF56059 (Glutathio...)
  8. cd06850 (biotinyl_d...)
  9. mobidb-lite (disord...)

Residue annotation

  1. carboxyltransferas...
  2. biotinylation site...

Protein sequence

>MCA_04835_1
MTSEVSSSLSNLSIGDQYDHSKLPKNFIGLNTIDNAPESEVKAFVKSHGGHSVIQSVLIANNGIAAVKNIRSVRKWAYET
FGNERAISFTVMATPEDLEANADYIRMADQYVEVPGGTNNNNYANVELIVDIAERYNCQAVWAGWGHASENPLLPDSLAA
SPKKIIFIGPPGSAMRSLGDKISSTIVAQHAKVPCIPWSGTGVDTVEFDKETGLVSISDEVYKMGCCSGPEDGLEKAKKI
GFPVMIKASEGGGGKGIRKVENEKDFISLYHQVEGEIPGSPIFIMKLAGNARHLEVQLLADQYGNNISLFGRDCSVQRRH
QKIIEEAPVTIANPKTFTEMEKAAVRLGKLVGYVSAGTVEYLYSHHDDKFYFLELNPRLQVEHPTTEMVTGVNLPAAQLQ
IAMGIPLHRITDIRLFYGVDPHTSTPIDFDFSTEDALKTQRRPVPRGHTTACRITSEDPGEGFKPSSGMMHELNFRSSSN
VWGYFSVGNQGGIHSFSDSQFGHIFAFGENRKASRQHMVVALKELSIRGDFRTTVEYLIKLLETPDFEQNKITTGWLDEL
ISKKLTVERPDMFIAVICGAATKAHIASEANLEEVQVSLEKGQAPARDTLKSIFAIDFIYEGQRFKFTATRSSVDAYTLF
INGSKIDVGVRALIDGGLLISLGGKSHSVYWKEEVGATRLSIDSKTCLLEVENDPTQLRTPSPGKLVKFLVENGEHVTAG
QPYAEVEVMKMYMPLVAQEDGVVQPIKQPGSTLQAGDILAILALDDPSKVKLAKPFEGQFPDMGTPTVIGMKTFQRFEVL
TKTLNNILAGFDNQVVMNRTLKELIEVLRNPNLPFGQWSQQASALHSRIPQKLDSILSSLVEKAKAKNADFPARQLLKSF
DKFVPHDPTDALIFRQAIEPLVSICNQYAEGLVAHEFKVINGFLEQYYEVEKLFSQPNLRDEDVILRLRDENRDDIKSVV
MTILSHSRVGAKNNLLLAIFNEYAPGKVESVNIAKYLRPSLKKIVELESRFTQKVVLKAREILIQCSLPSLKERSDQLEH
ILRSSVVETSYGEIGYDRRTPNLQNLKEVIDSKYTVFDVLTQFFNHSDPYVVLAALEVYVRRACRAYTILELNYHNEDGA
SPAVTWKFKLSSLAEAAFNTMTQPSTPSSPKDIQRSLSVSDLTFMADKGAEQDPVRTGVISPAVDFDDIDEAISNALEHL
PRKNDGFEFSSANSSRSSLAAQRRPAPAPAQSKFLSNVCSIMVRTETHMDDDTILARLKEVIEDYKDDLTACSVRRVTFV
IGEGVGKYPQYFTFRGPDYTEHKAIRHIEPALAFQLELGRLSNFNIKPIFTDNRNIHVYEATAKNASTDRRFFTRGIVRP
GKLRDEISTAEYLISEANRLMSDILDALEVIGTSNSDLNHIFINFSAVFSLEPEQVEAAFGGFLERFGRRLWRLRVTNAE
VRIVISEPKTGKTYPLRALINNVSGYVVESDLYAEVRNDKGEWIFKSLGKPGSMHLRPISTPYSTKESLQPKRYKAHLMG
TTYCYDFPDLFRQAIASNWKKFPNLKMPEDFFSSIELILDASGELSEINREPGTNNIGMIAWKVIAKTPEYPRGRKFVII
ANDITFKIGSFGPQEDAFFDAVTQMCRKEGIPRIYLSANSGARIGIAEELLPLFSVAWVDEKDPSKGFNYLYLTPTTYSD
LVKSGKKNSVIVERIVEDGEERYKIVTIVGLEDGLGVECLRGSGLIAGATSRAYKDIFTITLVTCRSVGIGAYLVRLGQR
SIQIEGQPIILTGAPAINKLLGREVYSSNLQLGGTQIMHKNGVSHLTATDDFAGVEKIVEWMSYVPAQRDLPVPVLETGD
NWDRDVEFTPSRNEPYDVRWLIAGKHNDDGSFESGLFDKDSFFETLNGWARGVVIGRARLGGIPFGVIGVETRTIENVIP
ADPANPDSTEVALQEAGQVWYPNSAYKTAQAINDFNQGEQLPLMILANWRGFSGGQRDMYNEVLKYGSYIVDALVNYKQP
IMIYIPPTGELRGGSWVVVDPTINPDMMEMYADEESRAGVLEPEGMVGIKFRKDKLIATMKRLDKKYADLCEQIEAAKKK
GAPESEISDLQSKLAEREEDLLPIYQQISVQFADLHDRVGRMEAKGTIRKALTWKDSRRYFFWRIRRRLNEEYLFKRIKE
VLPQSTRLEQVARVKSWYMSKVTDSDDDQAVALWLEENHKELAHNVTQLKKDSTTATFLSLLRSNKEQAVSGLAEAIKKL
SPAEREALLKQIQ

GO term prediction

Biological Process

GO:0006633 fatty acid biosynthetic process

Molecular Function

GO:0003824 catalytic activity
GO:0003989 acetyl-CoA carboxylase activity
GO:0004075 biotin carboxylase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0046872 metal ion binding

Cellular Component

None predicted.