Protein

MCA_04828_1

Length
898 amino acids

Gene name: DHR2

Description: Probable ATP-dependent RNA helicase DHR2; Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis

Browser: contigC:4188179-4190876-

RNA-seq: read pairs 774, FPKM 10.6, percentile rank 27.0% (100% = highest expression)

Protein function

Annotation:DHR2Probable ATP-dependent RNA helicase DHR2; Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis
KEGG:K14781DHR2 ATP-dependent RNA helicase DHR2 [EC:3.6.4.13]
EGGNOG:0PIUSDHR2atp-dependent rna helicase
SGD closest match:S000001561DHR2Probable ATP-dependent RNA helicase DHR2
CGD closest match:CAL0000190791orf19.107RNA helicase

Protein alignments

%idAln lengthE-value
MIA_03686_155.23%8980.0MIA_03686_1
A0A0J9X7C6_GEOCN59.77%7880.0Similar to Saccharomyces cerevisiae YKL078W DHR2 Predominantly nucleolar DEAH-box ATP-dependent RNA helicase OS=Geotrichum candidum GN=BN980_GECA05s00373g PE=4 SV=1
UniRef50_A0A0J9X7C659.77%7880.0Similar to Saccharomyces cerevisiae YKL078W DHR2 Predominantly nucleolar DEAH-box ATP-dependent RNA helicase n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X7C6_GEOCN
A0A167FZR7_9ASCO54.18%7290.0Dhr2p OS=Sugiyamaella lignohabitans GN=DHR2 PE=4 SV=1
A0A060SXA1_BLAAD53.40%7210.0ARAD1A07744p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A07744g PE=4 SV=1
Q6CEY0_YARLI51.12%7160.0YALI0B11968p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B11968g PE=4 SV=1
A0A1D8PPJ3_CANAL46.91%7120.0RNA helicase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.107 PE=4 SV=1
DHR2_YEAST46.87%7190.0Probable ATP-dependent RNA helicase DHR2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DHR2 PE=1 SV=1
A0A1E3PPV4_9ASCO50.63%4763e-155p-loop containing nucleoside triphosphate hydrolase protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45560 PE=4 SV=1
A0A1E4TMF7_9ASCO36.19%7132e-143Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_43522 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0141

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 100 200 300 400 500 600 700 800 898

Detailed signature matches

  1. Domain IPR014001
    Helicase superfamily 1/2, ATP-binding domain
    1. PS51192 (HELICASE_A...)
    2. SM00487 (ultradead3)
  2. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  3. Domain IPR011545
    DEAD/DEAH box helicase domain
    1. PF00270 (DEAD)
  4. Domain IPR001650
    Helicase, C-terminal
    1. PS51194 (HELICASE_CTER)
    2. SM00490 (helicmild6)
    3. PF00271 (Helicase_C)
  5. Domain IPR007502
    Helicase-associated domain
    1. SM00847 (ha2_5)
    2. PF04408 (HA2)
  6. Domain IPR011709
    Domain of unknown function DUF1605
    1. PF07717 (OB_NTP_bind)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. cd00046 (DEXDc)
  3. cd00079 (HELICc)
  4. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. putative Mg++ bind...
  3. nucleotide binding...
  4. ATP-binding site c...

Protein sequence

>MCA_04828_1
MPPKSHIKFSEDDDSVGTPIVQPQQDKKRPLNEPTLQSSKKQKSQRGFKINGQSEDSSSSKKLSGSFFSNKLNGKVRSDS
SSASDSPSSQDNLTPDSTSESSPLPSETKQKSANKSASARKQNLRKENTVKFFDSEDEADIIDGTSEEEDSEDEENRKKF
SSVKSLADHRLTASDYSKDKLFKAREKLKNKLFEIRKTLPMYQARKEVIEHIMENETTILLGETGSGKSTQLPQLLYEAA
REESLKNPKDKTKKTNESTKHQFLQKIAITQPRRVAAINLATRVCEEMGQELGFKVGYSVRFQSVDIRSTNSYIKYLTDG
MLLRELMINPTLSNYNTVILDEAHERTLLTDLSMGLLKQLQKDRRNTKNPLKLVIMSATLDAERFSKFFDNADILFVEGK
TYPVQRFYLNQPQDDAIDTMIQAACQINITEPTGDILAFLAGQEDIEKVVERINELAPLLSKEAPLLVAIPLYASLPNSA
QQLAFRKLSTAGRPKRKIIVATNIAETSVTVPGVRYVIDSGVRKVKVYNPDTGIDSLILTPISQAAASQRMGRAGREFPG
KCFRLYTEDFYNTEMRPQTEAEITRTDISSAILLLKQAGVDDILSFDWVESPGTNAIKSGLLKLYGLKALDDNGKITKLG
EQMVLLPVAPQLAACLLQAVHLGGIRLLSTVLDVAACLSVENLLMNPRADQRDEVNEHRKQNFPNAMEWGDLVMLKEMFD
MYLGIDSSTEKRAWCKQICLNKRAMDNVLKVREQLCNYMKGILGFKPESSSGRRRNSKKNKKNKKIQEDVEMNDYDGEEF
EPDELESNIDGQFDIALLLKCFLHGYISFTALGLPDRQYRSTMNGQLLTIHPSSMLFGQKREAIMYMNFVKTMKDYARCV
SPIKIEWLHEIAPHILQE

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003676 nucleic acid binding
GO:0004386 helicase activity
GO:0005524 ATP binding

Cellular Component

None predicted.