Protein

MCA_04759_1

Length
332 amino acids

Gene name: MDH1

Description: Malate dehydrogenase, mitochondrial

Browser: contigC:3964272-3965490-

RNA-seq: read pairs 43525, FPKM 1615.0, percentile rank 97.5% (100% = highest expression)

Protein function

Annotation:MDH1Malate dehydrogenase, mitochondrial
KEGG:K00026MDH2 malate dehydrogenase [EC:1.1.1.37]
EGGNOG:0PGCIMDH1Malate dehydrogenase
SGD closest match:S000001568MDH1Malate dehydrogenase, mitochondrial
CGD closest match:CAL0000181799MDH1-1Malate dehydrogenase

Protein alignments

%idAln lengthE-value
MIA_03701_187.35%3320.0MIA_03701_1
A0A0J9XHK6_GEOCN84.94%3320.0Malate dehydrogenase OS=Geotrichum candidum GN=BN980_GECA16s02804g PE=3 SV=1
A0A1E3PF88_9ASCO79.28%3330.0Malate dehydrogenase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_67249 PE=3 SV=1
A0A1E4TD17_9ASCO74.76%3173e-173Malate dehydrogenase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_141536 PE=3 SV=1
UniRef50_A0A093USS175.55%3192e-164Malate dehydrogenase, mitochondrial n=3 Tax=Dikarya TaxID=451864 RepID=A0A093USS1_TALMA
A0A060TB92_BLAAD77.14%3157e-170Malate dehydrogenase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B14036g PE=3 SV=1
Q6C8V3_YARLI76.66%3172e-166Malate dehydrogenase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D16753g PE=3 SV=1
Q5AMP4_CANAL73.04%3192e-162Malate dehydrogenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MDH1-1 PE=3 SV=1
MDHM_YEAST67.17%3321e-148Malate dehydrogenase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MDH1 PE=1 SV=2
A0A167CW50_9ASCO77.68%2331e-126Malate dehydrogenase OS=Sugiyamaella lignohabitans GN=MDH1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9874
Predicted cleavage: 17

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 332

Detailed signature matches

  1. Family IPR001557
    L-lactate/malate dehydrogenase
    1. PIRSF000102 (Lac_ma...)
  2. Family IPR010097
    Malate dehydrogenase, type 1
    1. TIGR01772
  3. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
  4. Domain IPR001236
    Lactate/malate dehydrogenase, N-terminal
    1. PF00056 (Ldh_1_N)
  5. Domain IPR015955
    Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
    1. SSF56327 (LDH C-ter...)
  6. Domain IPR022383
    Lactate/malate dehydrogenase, C-terminal
    1. PF02866 (Ldh_1_C)
  7. SITE IPR001252
    Malate dehydrogenase, active site
    1. PS00068 (MDH)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. G3DSA:3.90.11...
  3. cd01337 (MDH_glyoxy...)

Residue annotation

  1. NAD binding site c...
  2. dimerization inter...
  3. Substrate binding ...

Protein sequence

>MCA_04759_1
MSYIARRAFSSSARNAHKVAVLGAAGGIGQPLSLLLKLNKDVTSLSLYDIRGTPGVAADLSHIPTNSTVKGYLPENDGLA
KALEGVEVVVIPAGVPRKPGMTRDDLFNTNASIVRDLAKAVATTAPKALVAVIANPVNSTVPIVAEVFKAQGVYDPKRIF
GVTTLDVIRASRFISEVKGTDPTKETVTVVGGHSGHTIVPLISQSGHPDISGETLDALVHRIQFGGDEVVKAKDGAGSAT
LSMAQAGARFAGSLLKGLKGEEIVEPTFVDSPLFKDEGIEFFSSKVALGPEGVKEIFPLGQLNAYEEKLIATAKEDLKKN
ITKGVQFVASNP

GO term prediction

Biological Process

GO:0005975 carbohydrate metabolic process
GO:0006099 tricarboxylic acid cycle
GO:0006108 malate metabolic process
GO:0019752 carboxylic acid metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0016615 malate dehydrogenase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0030060 L-malate dehydrogenase activity

Cellular Component

None predicted.