Protein

MCA_04650_1

Length
343 amino acids

Gene name: HEM13

Description: Oxygen-dependent coproporphyrinogen-III oxidase

Browser: contigC:3601368-3602400+

RNA-seq: read pairs 5764, FPKM 207.0, percentile rank 88.5% (100% = highest expression)

Protein function

Annotation:HEM13Oxygen-dependent coproporphyrinogen-III oxidase
KEGG:K00228CPOX coproporphyrinogen III oxidase [EC:1.3.3.3]
EGGNOG:0PIF2HEM13coproporphyrinogen III oxidase
SGD closest match:S000002451HEM13Oxygen-dependent coproporphyrinogen-III oxidase
CGD closest match:CAL0000191428HEM13Coproporphyrinogen oxidase

Protein alignments

%idAln lengthE-value
MIA_04875_162.97%3433e-150MIA_04875_1
A0A0J9X6L1_GEOCN60.35%3439e-137Similar to Saccharomyces cerevisiae YDR044W HEM13 Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway OS=Geotrichum candidum GN=BN980_GECA04s04058g PE=4 SV=1
A0A060TJ26_BLAAD54.60%3377e-115ARAD1D43406p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D43406g PE=4 SV=1
A0A167EGV1_9ASCO51.91%3415e-112Coproporphyrinogen oxidase OS=Sugiyamaella lignohabitans GN=HEM13 PE=4 SV=1
UniRef50_K0KQ7651.17%3422e-105Coproporphyrinogen III oxidase, aerobic n=17 Tax=Opisthokonta TaxID=33154 RepID=K0KQ76_WICCF
HEM6_YEAST50.88%3404e-105Oxygen-dependent coproporphyrinogen-III oxidase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HEM13 PE=1 SV=2
Q59MR4_CANAL51.18%3402e-104Coproporphyrinogen oxidase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HEM13 PE=4 SV=1
A0A1E3PDC4_9ASCO48.83%3421e-100Coproporphyrinogen oxidase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_28891 PE=4 SV=1
Q6C438_YARLI51.61%3411e-98YALI0E29975p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E29975g PE=4 SV=1
A0A1E4TJ60_9ASCO42.17%3513e-84Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30139 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.3549

Protein family membership

Domains and repeats

None predicted.

Detailed signature matches

  1. Family IPR001260
    Coproporphyrinogen III oxidase, aerobic
    1. G3DSA:3.40.15...
    2. PR00073 (COPRGNOXDASE)
    3. PIRSF000166 (Coprop...)
    4. SSF102886 (Copropor...)
    5. PF01218 (Coprogen_o...)
  2. SITE IPR018375
    Coproporphyrinogen III oxidase, conserved site
    1. PS01021 (COPROGEN_O...)

Protein sequence

>MCA_04650_1
MASVRERMQKLIKDKQAEIVKVLESVEEEFSTTTPAKFFLDKWDRDDPKEGGGISAVIQGGDVIEKGGAMLSIVSSKLPP
AGVQRMRADHKALDILAEKQANVSNPVSLPFDVCGLSLIMHPKNPYAPTVHLNYRYFEIRDPDDDSKVITWWFGGGADLT
PHYLYEEDAQDFHAALKNACDTKLKSKKYYPKFKKWCDEYFYVKHRKENRGVGGIFFDDFGDASEDATDDEGNQLTQDDY
LAFVEACLDAYISSYPKILRRRCQTPYTEKEVKWQHIRRGRYVEFNLIYDRGTQFGLATPNARIESILVSLPLHSSWEYM
HAPEKGSHEEKTLEVLKHPKDWL

GO term prediction

Biological Process

GO:0006779 porphyrin-containing compound biosynthetic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004109 coproporphyrinogen oxidase activity

Cellular Component

None predicted.