MCA_04596_1

Protein

Length

589 amino acids

RNA-seq: read pairs 355, FPKM 7.4, percentile rank 21.3% (100% = highest expression)

Protein function

EGGNOG:	0PH49	PGUG_03666	transporter
SGD closest match:	S000003492	TNA1	High-affinity nicotinic acid transporter
CGD closest match:	CAL0000181841	CAALFM_CR03270WA	Uncharacterized protein

Protein alignments

	%id	Aln length	E-value
MIA_04989_1	71.09%	505	0.0	MIA_04989_1
A0A0J9XHB2_GEOCN	70.08%	488	0.0	Similar to Saccharomyces cerevisiae YGR260W TNA1 High affinity nicotinic acid plasma membrane permease OS=Geotrichum candidum GN=BN980_GECA16s02254g PE=4 SV=1
A0A1E3PKK4_9ASCO	62.62%	503	0.0	Vitamin H transporter 1 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_51107 PE=4 SV=1
A0A060T2P1_BLAAD	66.82%	437	0.0	ARAD1C26906p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C26906g PE=4 SV=1
A0A167DMK5_9ASCO	63.93%	438	0.0	Uncharacterized protein OS=Sugiyamaella lignohabitans GN=AWJ20_1354 PE=4 SV=1
Q6CCF5_YARLI	59.36%	502	0.0	YALI0C09823p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C09823g PE=4 SV=1
A0A1D8PSE5_CANAL	59.50%	437	7e-176	Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CAALFM_CR03270WA PE=4 SV=1
UniRef50_F2QQD8	60.64%	437	8e-170	High-affinitHigh affinity nicotinic acid plasma membrane permease n=53 Tax=Saccharomycetales TaxID=4892 RepID=F2QQD8_KOMPC
A0A1E4TM33_9ASCO	53.74%	441	1e-144	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_1420 PE=4 SV=1
TNA1_YEAST	24.85%	334	3e-18	High-affinity nicotinic acid transporter OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TNA1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2757

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
98 - 561
Major facilitator superfamily domain (IPR020846)

1 100 200 300 400 500 589

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  116 - 518
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. SSF103473 (MFS gene...)
  
  359 - 559
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
  
  98 - 326
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
2. cd06174 (MFS)
  
  116 - 561
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

576 - 589

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

435 - 445

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

300 - 377

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

500 - 510

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

179 - 184

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 111

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

233 - 243

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

100 - 312

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

366 - 581

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

132 - 159

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

531 - 549

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

266 - 276

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

465 - 475

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

204 - 208

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

404 - 414

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

381 - 403

TMHMM
TMhelix (TMhelix)

413 - 435

TMHMM
TMhelix (TMhelix)

447 - 466

TMHMM
TMhelix (TMhelix)

184 - 204

TMHMM
TMhelix (TMhelix)

244 - 266

TMHMM
TMhelix (TMhelix)

547 - 569

TMHMM
TMhelix (TMhelix)

209 - 231

TMHMM
TMhelix (TMhelix)

276 - 298

TMHMM
TMhelix (TMhelix)

113 - 135

TMHMM
TMhelix (TMhelix)

476 - 498

TMHMM
TMhelix (TMhelix)

505 - 527

TMHMM
TMhelix (TMhelix)

155 - 177

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

160 - 178

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

550 - 575

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

476 - 499

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

112 - 131

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

244 - 265

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

378 - 403

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

446 - 464

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

209 - 232

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

185 - 203

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

511 - 530

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

277 - 299

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

415 - 434

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

Residue annotation

putative substrate...

127T

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

130Y

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

131G

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

132N

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

134L

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

135T

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

159S

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

162Y

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

163Y

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

166Y

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

170D

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

171V

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

173M

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

174N

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

220G

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

221A

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

224W

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

225P

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

228A

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

229Y

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

232S

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

244I

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

245G

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

248F

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

249T

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

255A

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

389V

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

392G

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

393Y

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

396V

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

397V

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

400T

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

415L

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

419M

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

423W

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

426D

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

430I

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

480G

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

483L

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

484G

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

487V

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

491M

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

492T

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

495A

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

508A

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

509A

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

512A

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

515S

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

516G

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

519N

putative substrate translocation pore
127T, 130Y, 131G, 132N, 134L, 135T, 159S, 162Y, 163Y, 166Y, 170D, 171V, 173M, 174N, 220G, 221A, 224W, 225P, 228A, 229Y, 232S, 244I, 245G, 248F, 249T, 255A, 389V, 392G, 393Y, 396V, 397V, 400T, 415L, 419M, 423W, 426D, 430I, 480G, 483L, 484G, 487V, 491M, 492T, 495A, 508A, 509A, 512A, 515S, 516G, 519N
CDD
cd06174 (MFS)

Protein sequence

>MCA_04596_1
MPLDTNSHSFLINSTNSRINNITSKTHTQYRSFETTNQYITMNPEKNSTEYYNSINDDTNSNATSLSDAKVGQNISRSMR
PEESQQSSQIDLKSPEVQEKLDKLYRKLDLRIIPPLWCLYFLTSMGTSLYGNSLTMNMETNNSLRQQLKLTPHDTSTASA
LYYVGYILFDVPMNLLMTKLAPQAWLSRIVMTVGIVYACYASLSSSGGLIAVRLIAGICGAGTWPGMAYYISLWYPSHRT
ARRIGYYFTAAQLSASVAGLIAAGFQKMNMERGLTGFQWMYMLYGIVTFLVGFSLVWWLPDRPFKVFNDQLEGEIIEGDR
RIQKRGSLATFVDRFIPTQKPVLTPEEQELHKADMYGRYLNVSWGLMDLWKVFLDFRLWPLVIMYFGVVGTGYGIVVFGT
TILKSINSSWSSVTLSLLMAPIWMCDLIAILLITPFSDKFKNWRNTVFSSSTVVIIVGLVVTTYSPGNQWSRYGGLLITG
FGLGPTVPVCMTVAAEVFAPRHGDLGTAASAALVSGLGNLGSVTTTYALYSGWPADIARGYEYSNMVMVAILGASIIAAG
INAVVNGYVPVLSYAQKLRNKNKISDSTV

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features