Protein

MCA_04547_1

Length
831 amino acids

Gene name: DNM1

Description: Dynamin-related protein DNM1; Saccharomyces cerevisiae homologue is a dynamin-related GTPase involved in mitochondrial organization; required for mitochondrial fission and inheritance; self assembles on the cytoplasmic face of mitochondrial tubules at sites where division will occur.

Browser: contigC:3336964-3339527-

RNA-seq: read pairs 3023, FPKM 44.9, percentile rank 63.0% (100% = highest expression)

Protein function

Annotation:DNM1Dynamin-related protein DNM1; Saccharomyces cerevisiae homologue is a dynamin-related GTPase involved in mitochondrial organization; required for mitochondrial fission and inheritance; self assembles on the cytoplasmic face of mitochondrial tubules at sites where division will occur.
KEGG:K17065DNM1L dynamin 1-like protein [EC:3.6.5.5]
EGGNOG:0PF9UDNM1K17065 dynamin 1-like protein EC 3.6.5.5
SGD closest match:S000003924DNM1Dynamin-related protein DNM1
CGD closest match:CAL0000174679DNM1Dynamin-related GTPase

Protein alignments

%idAln lengthE-value
MIA_04638_187.99%5660.0MIA_04638_1
A0A0J9XB33_GEOCN85.38%5540.0Similar to Saccharomyces cerevisiae YLL001W DNM1 Dynamin-related GTPase required for mitochondrial fission and morphology OS=Geotrichum candidum GN=BN980_GECA07s03926g PE=3 SV=1
A0A1E3PKV7_9ASCO80.87%5540.0Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_46605 PE=3 SV=1
A0A167EUC0_9ASCO79.46%5600.0Dynamin-related GTPase DNM1 OS=Sugiyamaella lignohabitans GN=DNM1 PE=3 SV=1
Q6C1G8_YARLI77.94%5530.0YALI0F16379p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F16379g PE=3 SV=1
A0A060SZB5_BLAAD77.44%5540.0ARAD1C03828p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C03828g PE=3 SV=1
UniRef50_A0A094ADE474.59%5550.0Uncharacterized protein (Fragment) n=4 Tax=Ascomycota TaxID=4890 RepID=A0A094ADE4_9PEZI
A0A1E4TBA7_9ASCO73.14%5510.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_133114 PE=3 SV=1
DNM1_YEAST69.37%5550.0Dynamin-related protein DNM1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DNM1 PE=1 SV=1
A0A1D8PKC9_CANAL68.36%5720.0Dynamin-related GTPase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=DNM1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0479

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 100 200 300 400 500 600 700 831

Detailed signature matches

  1. Family IPR022812
    Dynamin superfamily
    1. PF00350 (Dynamin_N)
    2. PR00195 (DYNAMIN)
  2. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  3. Domain IPR001401
    Dynamin, GTPase domain
    1. SM00053 (dynamin_3)
  4. Domain IPR030381
    Dynamin-type guanine nucleotide-binding (G) domain
    1. PS51718 (G_DYNAMIN_2)
  5. Domain IPR000375
    Dynamin central domain
    1. PF01031 (Dynamin_M)
  6. Domain IPR020850
    GTPase effector domain
    1. PS51388 (GED)
  7. Domain IPR003130
    Dynamin GTPase effector
    1. SM00302 (GED_2)
    2. PF02212 (GED)
  8. SITE IPR019762
    Dynamin, GTPase region, conserved site
    1. PS00410 (G_DYNAMIN_1)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:3.40.50...
  3. cd08771 (DLP_1)
  4. mobidb-lite (disord...)

Residue annotation

  1. G1 box cd08771
  2. GTP/Mg2+ binding s...
  3. homodimer interfac...
  4. G2 box cd08771
  5. Switch I region cd...
  6. G3 box cd08771
  7. Switch II region c...
  8. G4 box cd08771
  9. G5 box cd08771

Protein sequence

>MCA_04547_1
MATLEDLIPLVNKLQDLVFNTIGTDTLDLPQVVVVGSQSSGKSSVLENIVGRDFLPRGTGIVTRRPLILQLVNLPSNGTS
QSSTTNAQTQSSYESPSSFEIGAGATSSAYPSAPNNVIPHTRSGPAAQYEEWGEFLHIPGQRFYDFNQIRREIEQETARI
AGTNKGINRIPINLKIFSPHVLNLTLVDLPGLTKIPIGDQPTDIERQTRNLILEYIAKPNSIILAVSPANVDLVNSESLK
LARQVDPQGKRTIGILTKLDLMDHGTNALDILSGNVYPLKLGFIGVVNRSQQDIHAQKSLSDALVAEREFFSSHPVYKNI
SHRCGTAFLAKSLNQTLMSHIRERLPDIKARLNTLMGQTEQELASYGDSTLFSSPENRGALLLTLMTKFATSFVASVDGT
SSEISTKELCGGARIYYIYNEVFGNSLNTLDPTTNLSMRDIRTAIRNSTGPRPSLFVPELAFDLLVKPQIKLLEPPSQRC
VELVYEELMKICHNCGSAELSRYPKLQAKLIEVISELLRERLGPTSSYVSSLISIQRAYINTNHPNFLGAAVAMQEVLEE
RKEKELQLKQFKAAEEARLQRLAEEQAAAEAESEKSASTNGSKKDKKTADSSDSKSQKNRKPSNASVKSDSTPQSSISTS
QLNGHAAHHSISAGNTNEPANKDSFLNYFFGKENNNNNNTKRSNMNGNSKKAIGGSSYQSSNFFGGNSSAASSSGLSSMD
TMVNEFEDALEGEDPLTERELLECELIRRLIVSYFSIVRESIQDQVPKAVMHLLVNFCKESAQNRLVSKLYKESLFEELL
HEDEALAQERSKCENLLKTYREAAKIIGEVV

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003924 GTPase activity
GO:0005525 GTP binding

Cellular Component

None predicted.