Protein

MCA_04516_1

Length
1,745 amino acids

Gene name: BEM3

Description: GTPase-activating protein BEM3

Browser: contigC:3245294-3250532-

RNA-seq: read pairs 3417, FPKM 24.2, percentile rank 46.7% (100% = highest expression)

Protein function

Annotation:BEM3GTPase-activating protein BEM3
EGGNOG:0PFGBPGUG_04047GTPase-activating protein
SGD closest match:S000006036BEM3GTPase-activating protein BEM3
CGD closest match:CAL0000193467BEM3Bem3p

Protein alignments

%idAln lengthE-value
MIA_01194_166.05%3241e-119MIA_01194_1
A0A0J9X973_GEOCN55.31%3111e-94Similar to Saccharomyces cerevisiae YPL115C BEM3 Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization OS=Geotrichum candidum GN=BN980_GECA06s03442g PE=4 SV=1
UniRef50_A0A0J9X97355.31%3113e-91Similar to Saccharomyces cerevisiae YPL115C BEM3 Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X973_GEOCN
Q6C6P3_YARLI56.86%2042e-68YALI0E07601p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E07601g PE=4 SV=1
A0A167E792_9ASCO43.51%2394e-49Bem3p OS=Sugiyamaella lignohabitans GN=BEM3 PE=4 SV=1
A0A1E3PM55_9ASCO43.38%2193e-47RhoGAP-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_50443 PE=4 SV=1
A0A060TE73_BLAAD45.50%1898e-42ARAD1D05346p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D05346g PE=4 SV=1
A0A1E4TIR4_9ASCO37.60%2587e-40Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_73681 PE=4 SV=1
A0A1D8PLJ2_CANAL39.22%2042e-38Bem3p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=BEM3 PE=4 SV=1
BEM3_YEAST39.65%2271e-34GTPase-activating protein BEM3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=BEM3 PE=1 SV=3

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.6044
Predicted cleavage: 49

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 200 400 600 800 1000 1200 1400 1600 1745

Detailed signature matches

  1. Domain IPR001683
    Phox homologous domain
    1. G3DSA:3.30.15...
    2. SSF64268 (PX domain)
  2. Domain IPR011993
    PH domain-like
    1. G3DSA:2.30.29.30
    2. SSF50729 (PH domain...)
  3. Domain IPR001849
    Pleckstrin homology domain
    1. PS50003 (PH_DOMAIN)
    2. SM00233 (PH_update)
    3. PF00169 (PH)
  4. Domain IPR008936
    Rho GTPase activation protein
    1. SSF48350 (GTPase ac...)
  5. Domain IPR000198
    Rho GTPase-activating protein domain
    1. SM00324 (RhoGAP_3)
    2. PF00620 (RhoGAP)
    3. PS50238 (RHOGAP)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:1.10.55...
  3. cd06093 (PX_domain)
  4. mobidb-lite (disord...)

Residue annotation

  1. phosphoinositide b...

Protein sequence

>MCA_04516_1
MPLPLISSSFKEIKNLSNSLKQPLSSHFHDNSSPSKSASSSTSKLVRHVSSKEKISDIFKKSRAPATVVHDKIEAYREGV
HQEQEKKKKERTRLEEKKDKTNDDSTNATVDPIIIMKNNNKTDEIKQEETNLDNDGQQSGSDPTVGYGGAYSNNSVCLYG
RRQDEDDSISIGSGSSSSSGGFSINSTANNNIINISTPPPTNKEENLNSPAFSHLTSSSVPTSSSPKDSTTTTPTPISPS
ISATGTFSLLRRSPPISTISHDSLAIIHSSPPSPHTQPATCLPALSAGNPTKNNNNNPLIINTFQSSESLHEKLPLHLHI
DTHASYDALLQNMDSQDSPVVTSAQLSPPSFPESTQNQQHSLKLEPSLPILNKKSSNSSLNSTERYSPGSTSLTKESKDA
EDKNDTSNSHSDLTASLNKLSIEDSNVITRTSSYDSSIAEETSFHENTPNNSQAQSGPVVTSSSLKPPNESQQQVNTTSN
VDGPSNFSQLTNPLVKQLAKNSSSNLLSTSLEESNPSTPPFTHSAPPTSATLSATSHYSTQTASANPSPINSTSSYSLEN
CTFNELKSILSEKLIQLSQVQNQNAQLWTLVNKQRTMIFDLQRDLDNAVEQNEKLARQLEFVKSANQSSTSLNSTNNSQQ
PLVNSSETSSLKTLNSIQNLSSSQVSSGKGLSVRTSSPSLKPSSYKVSRKPSTKEALSSLSSPPITGSEPSTSQNTDNTT
SSNGKANSLSRKPVSSSSSSITTSSNNNNISNDEKVNNNSAAILRPLSNGTNSSYVTAAESTPTTENIPYKVPRSPTVSA
RISTAYNFQDTTQSPSSAKRSQDDDNDDDYAEENETSNGHQHKKVPSSSSFDASSNTPRPTKRRPSPIVVVHGSDSASST
SPPNSGSSEKSAKHLPTGEIVNNIVTTNSSPSHPSSAPLKSTRTPTHGKSSSFDFSDQSKLHDHCYDSKWGISSPRRSES
SSVRPTQQQLTLYVQPEDLSSISLDISTLIGKVKSVYKPRREDPVAIINALDKETKKELWKVIKDYTSLVNLDNSIRPLL
YPQVPDLPKIPERSMFQSHAPSRVDARKTALEDYFQTILSQNLPHNVAQIVCEFLSTDTIDPMDIPDTPSKCEGYLTKRG
KKIRGWKVRYFIIETDSLNYYDKPGGELQGTISLRDAKLGRQTKTDADQNSEESVEKALRHAFLLLEHRKKDYVRHVLCA
ESDEERDHWIDALLEVISNFTTQTIPPLPASSNPATPIDNNRLLNGSENSNAQESLSSDQQSFQTEPTSTNSSTLSVKRK
PTAMASGEDSNPRAAALSSVNTQSTMSPITPSSVASTPTSAQMFSSTPTSSTFSSRLMPAASALSLGGYSKHIHESSSHQ
DLRPSGSHGDLDYDDGDTKEIKKSKKKSFFSFRNKTSSSNIGSSSSINNNSSNGNHAPAAPTSEFSDEFQSTPYSAVEQK
PMADEPQLQHQQPTYHTGPMYPPASQLQQAAVTAQLHPVSPSTSNPLIHNKALGMTLDEAVISQQEALANAENHTGSDSN
GTNPNISIEGDTSLNGDNLSRRVFGIPLVDAVHLSYKDVHHCRVPSIVYRCIELLKVRDAIFEEGIFRLNGAAATIRTLK
ERFNNEYDVDLVNSETYYDVHAVAGLLKLYLREIPTLILSSYLAPEFRDAVEIPDVTTKILKLKSLVQELPRENKDLLCV
LCSLLTEVIAHQDINKMNLRNVGIVFSLTLNISSSVLTSFLTDFDSIFGDAVPDETKSRAPDYPN

GO term prediction

Biological Process

GO:0007165 signal transduction

Molecular Function

GO:0035091 phosphatidylinositol binding

Cellular Component

None predicted.