MCA_04445_1
Gene name: FOL1
Description: Folic acid synthesis protein FOL1
Browser: contigC:3070234-3072856-
RNA-seq: read pairs 1293, FPKM 18.3, percentile rank 39.0% (100% = highest expression)
Protein function
| Annotation: | FOL1 | Folic acid synthesis protein FOL1 | |
|---|---|---|---|
| KEGG: | K13939 | FOL1 | dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase [EC:4.1.2.25 2.7.6.3 2.5.1.15] |
| EGGNOG: | 0PFZP | FOL1 | folic acid synthesis protein |
| SGD closest match: | S000005200 | FOL1 | Folic acid synthesis protein FOL1 |
| CGD closest match: | CAL0000194395 | FOL1 | Folic acid synthesis protein fol1 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_03639_1 | 63.42% | 853 | 0.0 | MIA_03639_1 |
| A0A0J9X692_GEOCN | 55.05% | 852 | 0.0 | Similar to Saccharomyces cerevisiae YNL256W FOL1 Multifunctional enzyme of the folic acid biosynthesis pathway OS=Geotrichum candidum GN=BN980_GECA03s06610g PE=4 SV=1 |
| A0A060T7D9_BLAAD | 52.07% | 845 | 0.0 | Folic acid synthesis protein fol1 OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D02464g PE=3 SV=1 |
| A0A167CKP3_9ASCO | 49.10% | 886 | 0.0 | Trifunctional dihydropteroate synthetase/dihydrohydroxymethylpterin pyrophosphokinase/dihydroneopterin aldolase FOL1 OS=Sugiyamaella lignohabitans GN=FOL1 PE=4 SV=1 |
| UniRef50_A0A167CKP3 | 49.10% | 886 | 0.0 | Trifunctional dihydropteroate synthetase/dihydrohydroxymethylpterin pyrophosphokinase/dihydroneopterin aldolase FOL1 n=1 Tax=Sugiyamaella lignohabitans TaxID=796027 RepID=A0A167CKP3_9ASCO |
| A0A1E3PNA3_9ASCO | 45.08% | 843 | 0.0 | Folic acid synthesis protein fol1 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_50333 PE=3 SV=1 |
| Q6CI15_YARLI | 43.08% | 852 | 0.0 | Folic acid synthesis protein fol1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A02541g PE=3 SV=1 |
| A0A1D8PN03_CANAL | 38.41% | 880 | 1e-172 | Folic acid synthesis protein fol1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=FOL1 PE=3 SV=1 |
| FOL1_YEAST | 32.96% | 895 | 1e-127 | Folic acid synthesis protein FOL1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FOL1 PE=1 SV=2 |
| A0A1E4T9L7_9ASCO | 31.40% | 863 | 3e-108 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_146155 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0148
Protein family membership
None predicted.
Domains and repeats
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Domain
Detailed signature matches
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SSF51717 (Dihydropt...)
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no IPR
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SSF55620 (Tetrahydr...)
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mobidb-lite (disord...)
Residue annotation
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homooctamer interf...
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active site cd00534
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catalytic center b...
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ATP binding site c...
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substrate binding ...
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dimer interface cd...
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inhibitor binding ...
Protein sequence
>MCA_04445_1 MPFSSSASAPSAVANTENGNVSNRLPASPDIVFVRDLFVKALTGVDAWHRPEPQPVKISIWLRTSVAQAGSTDHLAYSLN YAVITRKVTQMVEKGRFKTLEDIAEHVARIVLGDTVGGQWAKIQVCKPRALLRADASEIVITRQRIDKAPVNPLARNQSA NKNGSGDNSSVVSLSGDKFDVVKVPDVVDTVRIHNLRLVTIIGVNTIERLHKQNVILDLTLYKTNNTRFGVEPGMFDKTY DFRKVVQTVTDHVEDSSYKTVEAFVTSVAEVICSLGVSKVTVRAEKPSALTFADAAGVEVTRTKQYFDSLKKPGQQAVYE ETVNKDQAAINSTSGEGQAKALFPDSGPISESSDENSPASVSSANGQTHTVYIAFGSNIGDSLSIIKNSVEELNKSGVQV LETSSIYQSDPMYIKDQPKFYNGVFKAQTALSPLQLLETLKNIEYGNFGNRVKLQDNGPRTIDLDILLYDDWALNHPPTL IVPHLRMLERNFVLRPLADVVSPEMVHPLTAEPLHSHLEQLLSTASNGTVGEESTQESTVLQLVVPLPSHETGNNNRSIS FDPETQTCPTHVMAILNITTNSFSDGGRFTSEEADTVDVEKVSEAALKAVQDGATILDIGGMSTKPGTSASSVSPELEAK RVVAASKAIRTKASASNQDVVISIDTYRASVAEKAILEGQADIINDISGGLLDKDMFPTVAKLGVPIIINHTRGTPETMT RPEFSTYVWTNNLGDVETDTVDAVVECVGQELEARVSEALASGIKRWQIILDPGIGFAKSLKHNIILIKHLDRLKARPAL RGFAWLVGPSRKKFIGTLIGEEGKEKSLPKDRIWGTAATVSALIEKGVDIVRVHDVPEMVDVVKVSDAIFKNI
GO term prediction
Biological Process
GO:0006760 folic acid-containing compound metabolic process
GO:0009396 folic acid-containing compound biosynthetic process
GO:0042558 pteridine-containing compound metabolic process
GO:0044237 cellular metabolic process
Molecular Function
GO:0003848 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
GO:0004150 dihydroneopterin aldolase activity
GO:0004156 dihydropteroate synthase activity
Cellular Component
None predicted.