Protein

MCA_04422_1

Length
746 amino acids

Gene name: NTH1

Description: Neutral trehalase

Browser: contigC:3006670-3009211+

RNA-seq: read pairs 4401, FPKM 72.8, percentile rank 73.4% (100% = highest expression)

Protein function

Annotation:NTH1Neutral trehalase
KEGG:K01194TREH alpha,alpha-trehalase [EC:3.2.1.28]
EGGNOG:0PFDBNTH1Neutral trehalase
SGD closest match:S000002408NTH1Neutral trehalase
CGD closest match:CAL0000200632NTH1Trehalase

Protein alignments

%idAln lengthE-value
MIA_03920_171.47%7220.0MIA_03920_1
A0A0J9X2F7_GEOCN67.16%6820.0Trehalase OS=Geotrichum candidum GN=BN980_GECA01s01275g PE=3 SV=1
A0A1E3PKY8_9ASCO64.16%7060.0Trehalase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_46529 PE=3 SV=1
A0A060TAT7_BLAAD64.96%7050.0Trehalase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D26378g PE=3 SV=1
A0A167CV90_9ASCO64.62%7010.0Trehalase OS=Sugiyamaella lignohabitans GN=NTH1 PE=3 SV=1
UniRef50_A0A1E1JQ8661.29%7000.0Trehalase n=6 Tax=leotiomyceta TaxID=716546 RepID=A0A1E1JQ86_9HELO
TREA_YEAST61.10%7120.0Neutral trehalase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NTH1 PE=1 SV=3
A0A1E4TH47_9ASCO62.16%6660.0Trehalase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_24863 PE=3 SV=1
A0A1D8PRR3_CANAL58.53%6920.0Trehalase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=NTH1 PE=3 SV=1
Q6C8Z4_YARLI50.18%5604e-180Trehalase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D15598g PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0899
Predicted cleavage: 57

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 746

Detailed signature matches

  1. Family IPR001661
    Glycoside hydrolase, family 37
    1. PR00744 (GLHYDRLASE37)
    2. PF01204 (Trehalase)
  2. Domain IPR011120
    Neutral trehalase Ca2+ binding
    1. PF07492 (Trehalase_...)
  3. Domain IPR008928
    Six-hairpin glycosidase-like
    1. SSF48208 (Six-hairp...)
  4. SITE IPR018232
    Glycoside hydrolase, family 37, conserved site
    1. PS00927 (TREHALASE_1)
    2. PS00928 (TREHALASE_2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:1.50.10.10
  3. mobidb-lite (disord...)

Protein sequence

>MCA_04422_1
MPFSNNWDPYSNPSVYYGPTNDPSKINSQTNRSRSRSITDSKISLSNGSSNPIRRRGSKDELAKPRRFLFNVDQTLKTLL
ETEDTDNNYQITVDDEGPKVFLAGTADSLGYNTAEIRGTYMLSNLLQELTIAKKLGRHTVVIDEARLNENPVKRLSRLIQ
YQFWDSLTRRIDKDMIDTIAADPKNRGPDPRPRIYVPHTETEQYEYYTEIAKQRPELDLDVVYLPEKITPEWVKSVNEKP
GLLALDMYRTTDPETGKTTLKGVPYVVPGGRFNEFYGWDSYMESLGLITNNRVDLAMGMVKNFIFEIKHYGKILNANRSY
YLCRSQPPFLTDMALRVYDRIKGTDEAKQFLKEAFQAAIKEYKTVWTSSPRLDPKTGLSRYRPDGLGIPPETESSHFHIL
LEPYAKKYNISLEEFQRKYNDGEIKEPELDEYFLHDRAVRESGHDTSYRLEGRCADLATIDLNSLLYKYETDIAATIKSE
FGDSLEMPDGSIESSSEWLKRAEIRQAKVTKYMWNEEAGLFFDYDTKYEKQWEYETCTALWALYSGIATQEQAAKLVELG
LPKFEEVGGLVAGTEKSRGPISLNRPNRQWDYPYGWAPQQILAWIGLRNYGFNKDAERVAYKWLYMMTKAFMDFNGVVVE
KYDVTQLSHPHKVDAEYGNQGADFKGVATEGFGWVNASYVFGLSLLSNRARKALGAMNTPQDFIKQQQSGNDDDEEDDND
HAVVFDDIEDTILEEDQELEDGENQK

GO term prediction

Biological Process

GO:0005991 trehalose metabolic process
GO:0005993 trehalose catabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0004555 alpha,alpha-trehalase activity
GO:0005509 calcium ion binding

Cellular Component

GO:0005737 cytoplasm