Protein

MCA_04385_1

Length
499 amino acids

Gene name: RVB2

Description: RuvB-like helicase 2

Browser: contigC:2847369-2849105+

RNA-seq: read pairs 4067, FPKM 100.5, percentile rank 78.7% (100% = highest expression)

Protein function

Annotation:RVB2RuvB-like helicase 2
KEGG:K11338RUVBL2 RuvB-like protein 2 [EC:3.6.4.12]
EGGNOG:0PHPGRVB2DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity)
SGD closest match:S000006156RVB2RuvB-like protein 2
CGD closest match:CAL0000176498RVB2RuvB-like helicase 2

Protein alignments

%idAln lengthE-value
MIA_06054_184.04%4510.0MIA_06054_1
A0A0J9XEI6_GEOCN79.18%4900.0RuvB-like helicase OS=Geotrichum candidum GN=BN980_GECA12s02045g PE=3 SV=1
A0A1E3PT76_9ASCO72.06%5010.0RuvB-like helicase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81530 PE=3 SV=1
RUVB2_YARLI76.52%4600.0RuvB-like helicase 2 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=RVB2 PE=3 SV=2
A0A1E4TGI3_9ASCO75.22%4640.0RuvB-like helicase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_113130 PE=3 SV=1
A0A060SZU0_BLAAD74.35%4600.0RuvB-like helicase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C03300g PE=3 SV=1
RUVB2_CANAL72.26%4830.0RuvB-like helicase 2 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=RVB2 PE=3 SV=1
RUVB2_YEAST73.91%4600.0RuvB-like protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RVB2 PE=1 SV=1
A0A161HF26_9ASCO81.24%4210.0RuvB-like helicase OS=Sugiyamaella lignohabitans GN=RVB2 PE=3 SV=1
UniRef50_Q5BGK373.32%4610.0RuvB-like helicase 2 n=211 Tax=Eukaryota TaxID=2759 RepID=RUVB2_EMENI

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0996
Predicted cleavage: 64

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 450 499

Detailed signature matches

  1. Domain IPR010339
    TIP49, C-terminal
    1. PF06068 (TIP49)
  2. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  3. Domain IPR003593
    AAA+ ATPase domain
    1. SM00382 (AAA_5)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.8.60
  2. G3DSA:3.40.50...
  3. cd00009 (AAA)
  4. mobidb-lite (disord...)

Residue annotation

  1. Walker A motif cd0...
  2. ATP binding site c...

Protein sequence

>MCA_04385_1
MPTPDVTTKHSISTIAQAKELRGLNLIAAHSHITGLGLETGNKALQPWQSSQGMVGQLKARRAAAIVVKMIEEGKIAGRA
VLIAGPPSTGKTAIAMAISQSLGSSQSNVPFTTLAGSEVFSLEMSKTEALTQAFRKSIGVRIKEETEIIEGEVVEIQIDR
SITGGHKQGKLTIKTTDMETIYDLGAKMIESLSREKVTAGDVISLDKSSGKITKLGRSYSRSRDYDAMGPDTKFVQCPEG
ELQQRREIVHTVSLHDIDVINSRTQGFLALFSGDTGEIRSEVRDQINSKVSEWKEEGKAEIIPGVLFIDEVHMLDIESFS
FINRALEDELAPIVIMATNRGVSTTRGTSYKSPHGLPVDLLDRVIIISTTNYTSQEIQQILNIRAQEEEVEITPKALAVL
TKIGEETSLRYASNLISVSNLIATKRKSTKVDVEDITRAYSLFLDSNRSVKYMEENPDIFVGVDGQAKLGTSQTAEAPKT
VPASTTDATKPKEDTMDLS

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003678 DNA helicase activity
GO:0005524 ATP binding

Cellular Component

None predicted.