Protein
MCA_04365_1
Length
374 amino acids
Gene name: KAE1
Description: tRNA N6-adenosine threonylcarbamoyltransferase
Browser: contigC:2812585-2813784+
RNA-seq: read pairs 879, FPKM 29.0, percentile rank 51.7% (100% = highest expression)
Protein function
| Annotation: | KAE1 | tRNA N6-adenosine threonylcarbamoyltransferase | |
|---|---|---|---|
| KEGG: | K01409 | KAE1 | N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234] |
| EGGNOG: | 0PG1E | KAE1 | Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity). Component of the EKC KEOPS complex which promotes both telomere uncapping and telomere elongation (By similarity). The complex is required for efficient recruitment of transcriptional coactivators (By similarity) |
| SGD closest match: | S000001746 | KAE1 | tRNA N6-adenosine threonylcarbamoyltransferase |
| CGD closest match: | CAL0000176786 | KAE1 | tRNA N6-adenosine threonylcarbamoyltransferase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_04958_1 | 78.44% | 371 | 0.0 | MIA_04958_1 |
| A0A0J9X6I9_GEOCN | 75.73% | 375 | 0.0 | tRNA N6-adenosine threonylcarbamoyltransferase OS=Geotrichum candidum GN=KAE1 PE=3 SV=1 |
| A0A060THC2_BLAAD | 72.07% | 376 | 0.0 | tRNA N6-adenosine threonylcarbamoyltransferase OS=Blastobotrys adeninivorans GN=KAE1 PE=3 SV=1 |
| KAE1_CANAL | 70.05% | 374 | 0.0 | tRNA N6-adenosine threonylcarbamoyltransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=KAE1 PE=3 SV=1 |
| UniRef50_Q5A6A4 | 70.05% | 374 | 0.0 | tRNA N6-adenosine threonylcarbamoyltransferase n=34 Tax=Eukaryota TaxID=2759 RepID=KAE1_CANAL |
| A0A1E3PN05_9ASCO | 67.01% | 385 | 0.0 | tRNA N6-adenosine threonylcarbamoyltransferase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=KAE1 PE=3 SV=1 |
| KAE1_YARLI | 69.89% | 362 | 0.0 | tRNA N6-adenosine threonylcarbamoyltransferase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=KAE1 PE=3 SV=1 |
| KAE1_YEAST | 70.29% | 377 | 0.0 | tRNA N6-adenosine threonylcarbamoyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=KAE1 PE=1 SV=2 |
| A0A1E4TCC2_9ASCO | 62.47% | 373 | 3e-167 | tRNA N6-adenosine threonylcarbamoyltransferase OS=Tortispora caseinolytica NRRL Y-17796 GN=KAE1 PE=3 SV=1 |
| A0A161HH85_9ASCO | 76.06% | 213 | 5e-117 | Kae1p OS=Sugiyamaella lignohabitans GN=KAE1 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0202
Protein family membership
- Kae1/TsaD family (IPR017861)
Domains and repeats
-
Domain
1
50
100
150
200
250
300
374
Detailed signature matches
no IPR
Unintegrated signatures
-
-
SSF53067 (Actin-lik...)
Protein sequence
>MCA_04365_1 MPSIDYDRFLKPGKNSYIAIGLEGSANKLAVGIIKHHQGPPGVSSHSGDNAAEVLANIRDTYISPPGEGFLPRDTARHHR NWAVRLIKQALQEAGIKSSDLDCICYTMGPGMGAPLHTVSIVARVISLLWKVPLVPVNHCIGHIEMGREITHAENPVVLY VSGGNTQVIAYSHQKYRIFGETLDIAIGNCLDRFARTLMISNDPSPGYNIEQLAKKGKKYIPLPYTVKGMDMSMSGILAF IDDLAKTMFNKNKKGNNGKDVEYTPEDLCFSLQETLFAMLVEVTERAMAHVGSKEVLIVGGVGCNERLQEMMGQMAKDRG GSVFATDERFCIDNGLMIAQAGLLGYRTGDRIDVKDATTTQRFRTDQVLVKWRE
GO term prediction
Biological Process
GO:0002949 tRNA threonylcarbamoyladenosine modification
Molecular Function
None predicted.
Cellular Component
GO:0000408 EKC/KEOPS complex