Protein

MCA_04273_1

Length
402 amino acids

Gene name: ERG26

Description: Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

Browser: contigC:2561107-2562316+

RNA-seq: read pairs 3795, FPKM 116.4, percentile rank 81.2% (100% = highest expression)

Protein function

Annotation:ERG26Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating
KEGG:K07748E1.1.1.170 sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating) [EC:1.1.1.170]
EGGNOG:0PG64ERG26C-3 sterol dehydrogenase
SGD closest match:S000002969ERG26Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating
CGD closest match:CAL0000199131ERG26Sterol-4-alpha-carboxylate 3-dehydrogenase (Decarboxylating)

Protein alignments

%idAln lengthE-value
MIA_02292_165.50%4000.0MIA_02292_1
A0A0J9X420_GEOCN68.72%3748e-177Similar to Saccharomyces cerevisiae YGL001C ERG26 C-3 sterol dehydrogenase OS=Geotrichum candidum GN=BN980_GECA02s02089g PE=4 SV=1
A0A167FE08_9ASCO60.05%3736e-148Sterol-4-alpha-carboxylate 3-dehydrogenase (Decarboxylating) OS=Sugiyamaella lignohabitans GN=ERG26 PE=4 SV=1
UniRef50_A0A167FE0860.05%3732e-144Sterol-4-alpha-carboxylate 3-dehydrogenase (Decarboxylating) n=9 Tax=Saccharomycetales TaxID=4892 RepID=A0A167FE08_9ASCO
A0A060T6E9_BLAAD56.23%3611e-130ARAD1C13574p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C13574g PE=4 SV=1
ERG26_YEAST54.25%3651e-127Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ERG26 PE=1 SV=1
Q5A1B0_CANAL53.87%3621e-123Sterol-4-alpha-carboxylate 3-dehydrogenase (Decarboxylating) OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ERG26 PE=4 SV=1
A0A1E3PNS3_9ASCO54.35%3683e-121YGL001Cp-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81683 PE=4 SV=1
Q6CB38_YARLI46.13%3753e-98YALI0C22165p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C22165g PE=4 SV=1
A0A1E4TBD9_9ASCO40.81%3708e-74Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_133457 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1282

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 402

Detailed signature matches

  1. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
  2. Domain IPR002225
    3-beta hydroxysteroid dehydrogenase/isomerase
    1. PF01073 (3Beta_HSD)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...

Protein sequence

>MCA_04273_1
MSLTTDQIPGLDSIRNCTTGGKVRSKRQVLSIPEVKSVLLIGGCGFLGHHLIEEFWRVTPRPEIHVLDIRPLDKSSISPT
FFTFDPDQIHTYTGDITSPEDLKRVLKEAKPQVVVHSVSPVHGLGADIYHKVNVLGTRNIIKETKLDPNVQTLVYTSSAG
VVFNGADLKNADESTPYPAKAMDAYNETKAIAEVEVLSAATSYDNFVSKSSSSSSFAGELLTVSLRPAGIFGPGDRQMIP
ELRKMPARGQHKFQLGSNLNLFDTTYVGNVAFAHALATQKLLDPNTGAKVNGQCFFITNNSPIYFWAMGRAVWKADGYVD
PPKFVIPRGLGVFIGYISEFVSNLTGKAPGLTPFRVRTVCADRYYNISKAEKILGYKPQTDLESGILQTLKWLDELDSKK
KN

GO term prediction

Biological Process

GO:0006694 steroid biosynthetic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Cellular Component

None predicted.