Protein

MCA_04250_1

Length
609 amino acids

Gene name: FET3

Description: Iron transport multicopper oxidase FET3

Browser: contigC:2489662-2491492+

RNA-seq: read pairs 2952, FPKM 59.8, percentile rank 69.2% (100% = highest expression)

Protein function

Annotation:FET3Iron transport multicopper oxidase FET3
KEGG:K19791FET3_5 iron transport multicopper oxidase
EGGNOG:0PHHSFET3Iron transport multicopper oxidase
SGD closest match:S000004662FET3Iron transport multicopper oxidase FET3
CGD closest match:CAL0000197324FET31Fet31p

Protein alignments

%idAln lengthE-value
A0A0J9X8R9_GEOCN71.68%5720.0Similar to Saccharomyces cerevisiae YMR058W FET3 Ferro-O2-oxidoreductase required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity OS=Geotrichum candidum GN=BN980_GECA05s03805g PE=3 SV=1
MIA_02193_168.25%5700.0MIA_02193_1
Q9P861_BLAAD64.05%5730.0Ferro-O2-oxidoreductase OS=Blastobotrys adeninivorans GN=afet3 PE=3 SV=1
A0A167D2U0_9ASCO62.21%5690.0Ferroxidase FET3 OS=Sugiyamaella lignohabitans GN=FET3 PE=3 SV=1
A0A1E3PMF6_9ASCO62.26%5750.0Iron transport multicopper oxidase FET3 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82212 PE=3 SV=1
UniRef50_A0A0F7TTS554.33%5780.0Putative Ferro-O2-oxidoreductase n=19 Tax=Fungi TaxID=4751 RepID=A0A0F7TTS5_9EURO
Q6C9Y8_YARLI56.03%5800.0YALI0D07282p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D07282g PE=3 SV=1
A0A1D8PPE2_CANAL53.12%5760.0Fet31p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=FET31 PE=3 SV=1
FET3_YEAST52.77%5780.0Iron transport multicopper oxidase FET3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FET3 PE=1 SV=2
A0A1E4TKP0_9ASCO50.00%5860.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_42935 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0915

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 100 200 300 400 500 609

Detailed signature matches

  1. Domain IPR008972
    Cupredoxin
    1. G3DSA:2.60.40...
    2. SSF49503 (Cupredoxins)
  2. Domain IPR011707
    Multicopper oxidase, type 3
    1. PF07732 (Cu-oxidase_3)
  3. Domain IPR001117
    Multicopper oxidase, type 1
    1. PF00394 (Cu-oxidase)
  4. Domain IPR011706
    Multicopper oxidase, type 2
    1. PF07731 (Cu-oxidase_2)
  5. SITE IPR033138
    Multicopper oxidases, conserved site
    1. PS00079 (MULTICOPPE...)
  6. SITE IPR002355
    Multicopper oxidase, copper-binding site
    1. PS00080 (MULTICOPPE...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. NON_CYTOPLASM... (N...)
  3. SIGNAL_PEPTIDE (Sig...)
  4. SIGNAL_PEPTID... (S...)
  5. SIGNAL_PEPTID... (S...)
  6. SIGNAL_PEPTID... (S...)
  7. SignalP-noTM
  8. TMhelix
  9. TRANSMEMBRANE (Tran...)
  10. cd13851 (CuRO_1_Fet3p)
  11. cd13877 (CuRO_2_Fet...)
  12. cd13899 (CuRO_3_Fet3p)

Residue annotation

  1. Domain 2 interface...
  2. trinuclear Cu bind...
  3. Domain 3 interface...
  4. Domain 1 interface...
  5. Domain 3 interface...
  6. Domain 2 interface...
  7. Domain 1 interface...
  8. Type 1 (T1) Cu bin...
  9. trinuclear Cu bind...

Protein sequence

>MCA_04250_1
MKFAFTSAILMMAASALAKTHTFDWDIGWTTANPDGVKERQVVAINGKWPLPTIEVDKGDRVIVNVKNSLGDRNTSVHFH
GMYQNNTNYMDGPPMVVQCPILPGESFTYNFTVNQNGTYWYHSHVGGQYPDGYRAPFIVHDKDAPYANDYDEELTFTLSD
WYHELIELLDKDFLSIYNPSGAEPVPKNLLFNESQNSSIPVKPDTTYFIHIMNIGALGSTFVWFEDHNMTIVEVDGVYVE
PTEASILYITPAQRYTILLKTKNETDRNYGIVAAFDQTNFDVITPELQLNQTNWLEYNPDAPHNKPEIPYESSEDIEPFD
DFDLVPYDHLPLYPEPDQIFTVDVIMNNLMNGVNYAFFNNITYTSPKVPTLYTVMSAPDEVVNESLIYGEYTNTFVLEHL
HSIQLVVNNVDTGTHPFHMHGHHFQVIYRSPAYDDDSPTAWDPETNTSFPESPMRRDTVYVRPNGNMVLRFIADNPGVWV
FHCHIEWHLEQGLLLTLVEAPTQIRERMKIPDAHYDQCAKAGIPTKGNAAANVENFVDLTGQNKQQPDLPSGFTARGIVA
LVFSCVAAFVGMFTIAWYGLSDLPNTTKKMEELAEELDEEVHYDDPASR

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0005507 copper ion binding
GO:0016491 oxidoreductase activity

Cellular Component

None predicted.