Protein

MCA_04053_1

Length
366 amino acids

Gene name: IDH1

Description: Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial

Browser: contigC:1881703-1883723+

RNA-seq: read pairs 25620, FPKM 862.6, percentile rank 96.2% (100% = highest expression)

Protein function

Annotation:IDH1Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial
KEGG:K00030IDH3 isocitrate dehydrogenase (NAD+) [EC:1.1.1.41]
EGGNOG:0PFT1IDH1Isocitrate dehydrogenase
SGD closest match:S000004982IDH1Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial
CGD closest match:CAL0000189143IDH1Isocitrate dehydrogenase [NAD] subunit, mitochondrial

Protein alignments

%idAln lengthE-value
MIA_02211_185.18%3710.0MIA_02211_1
A0A0J9X7C4_GEOCN82.57%3730.0Isocitrate dehydrogenase [NAD] subunit, mitochondrial OS=Geotrichum candidum GN=BN980_GECA04s04036g PE=3 SV=1
A0A1E3PDQ5_9ASCO73.63%3640.0Isocitrate dehydrogenase [NAD] subunit, mitochondrial OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84534 PE=3 SV=1
A0A1E4TIT8_9ASCO71.54%3690.0Isocitrate dehydrogenase [NAD] subunit, mitochondrial OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_73737 PE=3 SV=1
Q6C6Z1_YARLI72.90%3690.0Isocitrate dehydrogenase [NAD] subunit, mitochondrial OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E05137g PE=3 SV=2
UniRef50_O1330268.85%3661e-172Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=81 Tax=Opisthokonta TaxID=33154 RepID=IDH1_AJECA
A0A167DT36_9ASCO74.32%3318e-172Isocitrate dehydrogenase [NAD] subunit, mitochondrial OS=Sugiyamaella lignohabitans GN=IDH1 PE=3 SV=1
A0A060TDF3_BLAAD67.45%3811e-169Isocitrate dehydrogenase [NAD] subunit, mitochondrial OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D43340g PE=3 SV=1
A0A1D8PEM5_CANAL70.62%3713e-169Isocitrate dehydrogenase [NAD] subunit, mitochondrial OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=IDH1 PE=3 SV=1
IDH1_YEAST65.35%3553e-161Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=IDH1 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9972
Predicted cleavage: 36

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 366

Detailed signature matches

  1. Family IPR004434
    Isocitrate dehydrogenase NAD-dependent
    1. TIGR00175
  2. Domain IPR024084
    Isopropylmalate dehydrogenase-like domain
    1. SM01329 (Iso_dh_2)
    2. PF00180 (Iso_dh)
  3. SITE IPR019818
    Isocitrate/isopropylmalate dehydrogenase, conserved site
    1. PS00470 (IDH_IMDH)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.71...
  2. SSF53659 (Isocitrat...)

Protein sequence

>MCA_04053_1
MLRTAFTRSTLRSFAAPAKRSLATLSEPTKYGGRYNVTLIPGDGIGAEITDSVKTIFKAENIPVDWEEINVHGVGDSASG
IEEAILSLKRNKVGLKGILYTPVEKTGHASFNVALRRELDIYASVVLIKNIPGVKTRMDGIDMVLIRENTEGEYSGLEHQ
SVPGVVESLKIITKYKSERIARFAYDFAIKNNRKKVTAIHKANIMKLADGLFRATVREVGQDYPSIEYSDMIVDNASMQA
VSRPQQFDILVTPNLYGTILGNIGAALVGGPGLVPGVNLGREHAVFEPGCRHVGLDLKGRNEANPAAMILSSSMMLRHLG
LDNHADRVSKATYDVIASGVARTKDLGGNASTTDFTKAVLNRLEKL

GO term prediction

Biological Process

GO:0006099 tricarboxylic acid cycle
GO:0055114 oxidation-reduction process

Molecular Function

GO:0000287 magnesium ion binding
GO:0004449 isocitrate dehydrogenase (NAD+) activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding

Cellular Component

None predicted.