Protein

MCA_04048_1

Length
319 amino acids

Browser: contigC:1872369-1873329-

RNA-seq: read pairs 2094, FPKM 80.9, percentile rank 75.4% (100% = highest expression)

Protein function

KEGG:K00948PRPS ribose-phosphate pyrophosphokinase [EC:2.7.6.1]
EGGNOG:0PGG8FG09299.1ribose-phosphate pyrophosphokinase
SGD closest match:S000000901PRS2Ribose-phosphate pyrophosphokinase 2
CGD closest match:CAL0000186972orf19.4611Ribose phosphate diphosphokinase subunit

Protein alignments

%idAln lengthE-value
A0A0J9XDZ5_GEOCN89.97%3190.0Similar to Saccharomyces cerevisiae YER099C PRS2 5-phospho-ribosyl-1(Alpha)-pyrophosphate synthetase OS=Geotrichum candidum GN=BN980_GECA09s04289g PE=4 SV=1
MIA_02216_187.66%3160.0MIA_02216_1
A0A167C485_9ASCO86.60%3210.0Ribose phosphate diphosphokinase subunit PRS2 OS=Sugiyamaella lignohabitans GN=PRS2 PE=4 SV=1
Q6C3T1_YARLI82.39%3180.0YALI0E32351p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E32351g PE=4 SV=1
A0A1E4TA52_9ASCO80.76%3170.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_3275 PE=4 SV=1
UniRef50_A0A0E9N8N878.23%3172e-176Uncharacterized protein n=10 Tax=Opisthokonta TaxID=33154 RepID=A0A0E9N8N8_9ASCO
A0A060TA08_BLAAD75.24%3197e-178ARAD1D19514p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D19514g PE=4 SV=1
KPR2_YEAST73.90%3182e-177Ribose-phosphate pyrophosphokinase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRS2 PE=1 SV=1
A0A1E3PMX7_9ASCO75.62%3209e-177Phosphoribosyl pyrophosphokinase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82410 PE=4 SV=1
Q5AMN5_CANAL69.91%3191e-171Ribose phosphate diphosphokinase subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.4611 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.7731

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 319

Detailed signature matches

  1. Family IPR005946
    Ribose-phosphate diphosphokinase
    1. PF14572 (Pribosyl_s...)
    2. TIGR01251
  2. Domain IPR029099
    Ribose-phosphate pyrophosphokinase, N-terminal domain
    1. PF13793 (Pribosyltr...)
  3. Domain IPR029057
    Phosphoribosyltransferase-like
    1. SSF53271 (PRTase-like)
  4. Domain IPR000836
    Phosphoribosyltransferase domain
    1. cd06223 (PRTases_typeI)
  5. SITE IPR000842
    Phosphoribosyl pyrophosphate synthetase, conserved site
    1. PS00114 (PRPP_SYNTHASE)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. SM01400 (Pribosyltr...)

Residue annotation

  1. active site cd06223

Protein sequence

>MCA_04048_1
MATSSNSIKLLAGNSHPALAKAVATRLGIELSKINVSQYANQETSVTIGESVRDEDVFILQTGCGEVNDYLMELLIMIHA
CKTASARRITAVIPNFPYARQDKKDKSRAPITAKLMANMLQTAGCNHVITMDLHASQIQGFFDVPVDNLYAEPSTLRYIR
ENIDYKNSVIVSPDAGGAKRAASIADKLDLNFALIHKERQRANEVSRMVLVGDVKDKICILVDDMADTCGTLVKAADTLI
SNGAKSVIALVTHGIFSGPAFKRINESPIDKVVCTNTVPHDDANCPKLDHIDISPTLAEAIRRLHNGESISYLFTHDPL

GO term prediction

Biological Process

GO:0009116 nucleoside metabolic process
GO:0009156 ribonucleoside monophosphate biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0044249 cellular biosynthetic process

Molecular Function

GO:0000287 magnesium ion binding
GO:0004749 ribose phosphate diphosphokinase activity

Cellular Component

None predicted.