Protein

MCA_03975_1

Length
390 amino acids

Gene name: THI80

Description: thiamine pyrophosphokinase

Browser: contigC:1675019-1676366-

RNA-seq: read pairs 2661, FPKM 84.1, percentile rank 76.1% (100% = highest expression)

Protein function

Annotation:THI80thiamine pyrophosphokinase
KEGG:K00949thiN thiamine pyrophosphokinase [EC:2.7.6.2]
EGGNOG:0PMIXPGUG_02670thiamine pyrophosphokinase
SGD closest match:S000005669THI80Thiamine pyrophosphokinase
CGD closest match:CAL0000183714orf19.1110Thiamine diphosphokinase

Protein alignments

%idAln lengthE-value
MIA_05903_141.28%3901e-76MIA_05903_1
A0A060T4L8_BLAAD29.95%3742e-42ARAD1A18634p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A18634g PE=4 SV=1
A0A1E3PMN0_9ASCO44.44%1621e-38Thiamin pyrophosphokinase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82431 PE=4 SV=1
UniRef50_A0A1E3PMN044.44%1623e-35Thiamin pyrophosphokinase n=1 Tax=Nadsonia fulvescens var. elongata DSM 6958 TaxID=857566 RepID=A0A1E3PMN0_9ASCO
A0A0J9XIL7_GEOCN36.50%2001e-30Similar to Saccharomyces cerevisiae YOR143C THI80 Thiamine pyrophosphokinase OS=Geotrichum candidum GN=BN980_GECA17s00043g PE=4 SV=1
THI80_YEAST33.33%2011e-23Thiamine pyrophosphokinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=THI80 PE=1 SV=1
Q6C536_YARLI43.53%853e-19YALI0E21351p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E21351g PE=4 SV=1
A0A1D8PNT8_CANAL29.50%2008e-17Thiamine diphosphokinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.1110 PE=4 SV=1
A0A167FFD0_9ASCO41.67%967e-16Thiamine diphosphokinase OS=Sugiyamaella lignohabitans GN=THI80 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0239

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 390

Detailed signature matches

  1. Domain IPR007371
    Thiamin pyrophosphokinase, catalytic domain
    1. PF04263 (TPK_catalytic)
    2. G3DSA:3.40.50...
    3. cd07995 (TPK)
    4. SSF63999 (Thiamin p...)
  2. Domain IPR007373
    Thiamin pyrophosphokinase, vitamin B1-binding domain
    1. G3DSA:2.60.12...
    2. PF04265 (TPK_B1_bin...)
    3. SSF63862 (Thiamin p...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. mobidb-lite (disord...)

Residue annotation

  1. active site cd07995
  2. dimerization inter...
  3. thiamine binding s...

Protein sequence

>MCA_03975_1
MSSDDVFRLDPASFLENISKIDQNDQSLEISTTTTDPKAVLIILNLPILDVPVPTPKSSSSASHSVEQTTTIFETLWNHC
KYKICADGGANRLYNYVKKRPELQTKFIPDVIAGDLDSARPSVLKYFRSKGVDIRKDHDQYSTDLMKCITLAEKLWFSGD
STESNKDEPTTPGSYAFNVYALGGLGGRVDQSFHSLHHLHVSNNISSGKIPPSNNNKASESDSKEKESTATKSEAKSSSE
PSSSLITEDDDYLYLEQRPTLPHTLTLISFTSPTQANLTFLVPEGWTQIRMSKDHLGPALGIIPMLGATELSTRGLVYDV
DKWITEFGNKVSTSNYLWTYNESNSEEYKETNETRPDHGESIVNIGCDKPVIITIEIRSSVNEDDEDYEE

GO term prediction

Biological Process

GO:0009229 thiamine diphosphate biosynthetic process

Molecular Function

GO:0004788 thiamine diphosphokinase activity
GO:0005524 ATP binding
GO:0030975 thiamine binding

Cellular Component

None predicted.