MCA_03736_1
Gene name: GLR1
Description: Glutathione reductase
Browser: contigC:934988-936416+
RNA-seq: read pairs 24737, FPKM 642.1, percentile rank 95.2% (100% = highest expression)
Protein function
| Annotation: | GLR1 | Glutathione reductase | |
|---|---|---|---|
| KEGG: | K00383 | GSR | glutathione reductase (NADPH) [EC:1.8.1.7] |
| EGGNOG: | 0PG30 | GLR1 | Glutathione reductase |
| SGD closest match: | S000006012 | GLR1 | Glutathione reductase |
| CGD closest match: | CAL0000194377 | GLR1 | Glutathione-disulfide reductase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_00933_1 | 71.40% | 479 | 0.0 | MIA_00933_1 |
| A0A0J9X711_GEOCN | 68.48% | 479 | 0.0 | Similar to Saccharomyces cerevisiae YPL091W GLR1 Cytosolic and mitochondrial glutathione oxidoreductase,converts oxidized glutathione to reduced glutathione OS=Geotrichum candidum GN=BN980_GECA04s06060g PE=3 SV=1 |
| A0A1E3PJN5_9ASCO | 64.60% | 483 | 0.0 | Glutathione reductase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_50927 PE=3 SV=1 |
| A0A167D5D5_9ASCO | 62.73% | 483 | 0.0 | Glutathione-disulfide reductase GLR1 OS=Sugiyamaella lignohabitans GN=GLR1 PE=3 SV=1 |
| A0A060T9F0_BLAAD | 60.38% | 477 | 0.0 | ARAD1C44110p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C44110g PE=3 SV=1 |
| GSHR_YARLI | 61.86% | 472 | 0.0 | Glutathione reductase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=GLR1 PE=3 SV=1 |
| UniRef50_Q873E8 | 58.26% | 448 | 3e-170 | Glutathione reductase n=158 Tax=Eukaryota TaxID=2759 RepID=GSHR_NEUCR |
| GSHR_YEAST | 59.75% | 477 | 2e-172 | Glutathione reductase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GLR1 PE=1 SV=2 |
| Q59NQ5_CANAL | 56.77% | 495 | 1e-164 | Glutathione-disulfide reductase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=GLR1 PE=3 SV=1 |
| A0A1E4TFE1_9ASCO | 53.44% | 451 | 2e-148 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_57000 PE=3 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.3509
Predicted cleavage: 27
Protein family membership
- Glutathione reductase, eukaryote/bacterial (IPR006322)
Domains and repeats
-
Domain
Detailed signature matches
no IPR
-
-
PIRSF000350 (Hg-II_...)
-
PR00368 (FADPNR)
-
PR00411 (PNDRDTASEI)
Protein sequence
>MCA_03736_1 MAPINVTHYKYLVIGGGSGGVASARRAAKFGAKTLLIEGKALGGTCVNVGCVPKKVMWSAATMAKSITEARNYGFDGVDA SLVDTFNWPAFKAKRDAYVKRLNGIYARNLEKEGVDFIFGWAKFLNQHTVEVKLNEPDEEGNTTKQFTADHILIATGGAA TIPDNVSGAEHGITSDGFFELEQKPEAVAVVGAGYIGVELAGVFSSLNVKTHLFIRHDKLLRKFDPMIQDTLTEIYEKHL ELHKNSCILNVEKLDNGKLKLTFRDGSEQNTTTVDALIWTIGRHTLKDDLNLEAVGVKVDPKTGVVITDEYQNTSTPNIY SVGDVSGPIDLTPVAIAAGRKLAMRLFAGEEYKDLKQSYENVPSAVFAHPEIGAIGLTEPEAREKFGDENVKVYKSKFTA MYYAPLDDEQKYPTAYKLVVTGPEEKVVGLHLIGDASSEILQGFGVAVKMGATKKDFDSVVAIHPTSAEEIVTLV
GO term prediction
Biological Process
GO:0006749 glutathione metabolic process
GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process
Molecular Function
GO:0004362 glutathione-disulfide reductase activity
GO:0016491 oxidoreductase activity
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
Cellular Component
None predicted.