Protein
MCA_03724_1
Length
844 amino acids
Gene name: MEF2
Description: Ribosome-releasing factor 2, mitochondrial
Browser: contigC:890399-892934-
RNA-seq: read pairs 1272, FPKM 18.6, percentile rank 39.5% (100% = highest expression)
Protein function
Annotation: | MEF2 | Ribosome-releasing factor 2, mitochondrial | |
---|---|---|---|
KEGG: | K02355 | fusA | elongation factor G |
EGGNOG: | 0PGST | MEF2 | Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation (By similarity) |
SGD closest match: | S000003638 | MEF2 | Ribosome-releasing factor 2, mitochondrial |
CGD closest match: | CAL0000188276 | MEF2 | Ribosome-releasing factor 2, mitochondrial |
Protein alignments
%id | Aln length | E-value | ||
---|---|---|---|---|
MIA_01216_1 | 68.14% | 816 | 0.0 | MIA_01216_1 |
A0A0J9X3Y8_GEOCN | 65.60% | 814 | 0.0 | Ribosome-releasing factor 2, mitochondrial OS=Geotrichum candidum GN=MEF2 PE=3 SV=1 |
UniRef50_A0A0J9X3Y8 | 65.60% | 814 | 0.0 | Ribosome-releasing factor 2, mitochondrial n=2 Tax=Saccharomycetales TaxID=4892 RepID=A0A0J9X3Y8_GEOCN |
A0A060TIL3_BLAAD | 57.64% | 812 | 0.0 | Ribosome-releasing factor 2, mitochondrial OS=Blastobotrys adeninivorans GN=MEF2 PE=3 SV=1 |
A0A167ERQ2_9ASCO | 56.55% | 824 | 0.0 | Ribosome-releasing factor 2, mitochondrial OS=Sugiyamaella lignohabitans GN=MEF2 PE=3 SV=1 |
A0A1E3PN38_9ASCO | 52.56% | 841 | 0.0 | Ribosome-releasing factor 2, mitochondrial OS=Nadsonia fulvescens var. elongata DSM 6958 GN=MEF2 PE=3 SV=1 |
RRF2M_YARLI | 49.94% | 831 | 0.0 | Ribosome-releasing factor 2, mitochondrial OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=MEF2 PE=3 SV=1 |
RRF2M_CANAL | 41.82% | 837 | 0.0 | Ribosome-releasing factor 2, mitochondrial OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MEF2 PE=3 SV=2 |
A0A1E4T9Z5_9ASCO | 43.64% | 818 | 0.0 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_3250 PE=4 SV=1 |
RRF2M_YEAST | 42.05% | 837 | 0.0 | Ribosome-releasing factor 2, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MEF2 PE=1 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.7468
Protein family membership
- Ribosome-releasing factor 2, mitochondrial (IPR030851)
Domains and repeats
-
Domain
-
Domain
1
100
200
300
400
500
600
700
844
Detailed signature matches
no IPR
Unintegrated signatures
-
-
-
-
-
PF14492 (EFG_II)
-
cd01886 (EF-G)
-
mobidb-lite (disord...)
Residue annotation
-
G1 box cd01886
-
putative GEF inter...
-
GTP/Mg2+ binding s...
-
Switch I region cd...
-
G2 box cd01886
-
G3 box cd01886
-
Switch II region c...
-
G4 box cd01886
-
G5 box cd01886
Protein sequence
>MCA_03724_1 MVQLRTPFIKGTRLLCQTNNNQLVPFVNRYSKAYSTETRKDSKLLRNIGIIAHIDAGKTTTTERMLYYSGLTNRIGDVDQ GDTVMDYLPAERDRGITITSAAITLNWAKHKINLIDTPGHADFTFEVIRSIRVLDGAVTILDGVAGVEAQTEKVWKQATE VGIPKIAFVNKMDREGAGFGRTVREIVSKLNTRVGIVNMPFYKDGDYSNGGGDGKSFEGVVDVVNKKIIKWNNTTSTEAK DDGKDVTVMDISKYESVTKECELAREALIETLSEFDDELVEHYLEVGDYMEVSPSQIKRALRKACLEKKVVPVLCGASFR NIGVQPLLDAVIDYLPSPQDIPSPDALITGVSVKNGRKNVIQPDQKIKLEALKNPNLTSALAFKVVFDQKKGMMVYVRVY SGSLHQNSSVLNSTTGKRERVMKLYQMHANEPIEVPSIEKGNIGVIVGTKEIRTGDTIVGHAVKRDGVKSLTPRESHLQL QSIKVPPPVFFSSIDPLTLADTKNMEEALHILLTEDPSLHIITDEDSGQTMLSGMGELHLEISKDRLVGDLKARVEVGKI MVSYKETINESSKSVTMEGTSAPQGADTNAITSKVVLKLEPVFEDEEPNGSDIEVSRDNIFVRLPQDIPDHPLISTQDLI RAVKVGVVPGVARGGLKARLPLHSLRVNVESITVPLDATHASSVSIAVRLAVEEALESIPKESYTIMEPMMDVKVVVSEE DVGAVVNDLSSNRRGSISSLQDDSSSSSSTGSTEGLLNDEVNFKELAGTIYTPPDFTMYMSKHGDRMRSNQNIVSAHVPL QQMVGYLNYLRSLTKGRGTFLMDFHSYRRVSADRENEILNEDEF
GO term prediction
Biological Process
GO:0032790 ribosome disassembly
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Cellular Component
GO:0005739 mitochondrion