Protein

MCA_03707_1

Length
481 amino acids

Gene name: PKP1C

Description: [Pyruvate dehydrogenase (acetyl-transferring)] kinase 1, mitochondrial

Browser: contigC:833060-834506-

RNA-seq: read pairs 2563, FPKM 65.7, percentile rank 71.2% (100% = highest expression)

Protein function

Annotation:PKP1C[Pyruvate dehydrogenase (acetyl-transferring)] kinase 1, mitochondrial
KEGG:K00898PDK2_3_4 pyruvate dehydrogenase kinase 2/3/4 [EC:2.7.11.2]
EGGNOG:0PHX7PGUG_05616Pyruvate dehydrogenase kinase
SGD closest match:S000001304PKP1[Pyruvate dehydrogenase (acetyl-transferring)] kinase 1, mitochondrial
CGD closest match:CAL0000180154PDK2Protein kinase

Protein alignments

%idAln lengthE-value
MIA_06022_168.97%5060.0MIA_06022_1
Q6CB64_YARLI65.01%4830.0YALI0C21582p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C21582g PE=4 SV=2
UniRef50_Q6CB6465.01%4830.0YALI0C21582p n=123 Tax=Fungi TaxID=4751 RepID=Q6CB64_YARLI
A0A0J9X995_GEOCN65.35%4820.0Similar to Saccharomyces cerevisiae YIL042C PKP1 Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity OS=Geotrichum candidum GN=BN980_GECA06s03684g PE=4 SV=1
A0A1E3PSG6_9ASCO62.42%4790.0Pyruvate dehydrogenase kinase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_19956 PE=4 SV=1
A0A167D8E5_9ASCO62.63%4870.0Protein kinase PKP1 OS=Sugiyamaella lignohabitans GN=PKP1 PE=4 SV=1
A0A060T4Z7_BLAAD59.68%5010.0ARAD1C07326p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C07326g PE=4 SV=1
A0A1E4TEQ5_9ASCO59.54%4770.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_104124 PE=4 SV=1
A0A1D8PTU9_CANAL49.33%5251e-166Protein kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PDK2 PE=4 SV=1
PDK1_YEAST23.17%3155e-20[Pyruvate dehydrogenase (acetyl-transferring)] kinase 1, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PKP1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.7225
Predicted cleavage: 30

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 50 100 150 200 250 300 350 400 450 481

Detailed signature matches

  1. Domain IPR018955
    Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
    1. SSF69012 (alpha-ket...)
    2. G3DSA:1.20.14...
    3. PF10436 (BCDHK_Adom3)
  2. Domain IPR003594
    Histidine kinase-like ATPase, C-terminal domain
    1. G3DSA:3.30.56...
    2. PF02518 (HATPase_c)
    3. SSF55874 (ATPase do...)
    4. SM00387 (HKATPase_4)
  3. Domain IPR005467
    Histidine kinase domain
    1. PS50109 (HIS_KIN)
  4. Domain IPR004358
    Signal transduction histidine kinase-related protein, C-terminal
    1. PR00344 (BCTRLSENSOR)
Unintegrated signatures no IPR
Unintegrated signatures
  1. cd00075 (HATPase_c)
  2. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. Mg2+ binding site ...
  3. G-X-G motif cd00075

Protein sequence

>MCA_03707_1
MSGWKLTPELTKKIYHYARFPATGVSLRQMVQFGARPSQGTLFRASQFVTEELPIRLAHRVKDLESLPYNLSEMPSIKKV
RDWYAQSFEELTSLKTPKLDQDLKQKLFRPKSHPQITELDGHMNGHHNHHHHHHHEKAKDVAIKPEPADMESNNQHHSHN
LITTSTENPSLEPWHYNTNPGQKRAINNRRYFANVEQDVIWPPEIYEYNRVITSTLKKIKRRHDAVVTTVAQGVVEWKNS
FSADSHTHSRGHGNLKDESVQAFLDRFYMSRIGIRMLIGQHIALNEEPVREDYVGIICTSVPIREMAQLASDNARFICEE
YYGLFEAPKIEIVCPEDLTFMYVPGHLNHMLFETIKNSLRAVVEFHGVDADHYPPVKIIVAEGNEDITIKISDEGGGIPR
SEVPNAWMYMYTTVKSTPSLDPDFNKSDFKAPMAGFGYGLPISRLYARYFGGDLKLISMEGYGTDVYLHLNRLSSSSEPL
Q

GO term prediction

Biological Process

GO:0016310 phosphorylation

Molecular Function

GO:0016772 transferase activity, transferring phosphorus-containing groups

Cellular Component

None predicted.