Protein

MCA_03611_1

Length
725 amino acids

Gene name: SUP35

Description: Eukaryotic peptide chain release factor GTP-binding subunit

Browser: contigC:539869-542047-

RNA-seq: read pairs 14131, FPKM 240.5, percentile rank 90.1% (100% = highest expression)

Protein function

Annotation:SUP35Eukaryotic peptide chain release factor GTP-binding subunit
KEGG:K03267ERF3 peptide chain release factor subunit 3
EGGNOG:0PI1BSUP35eukaryotic peptide chain release factor GTP-binding subunit
SGD closest match:S000002579SUP35Eukaryotic peptide chain release factor GTP-binding subunit
CGD closest match:CAL0000176993SUP35Translation termination factor GTPase eRF3

Protein alignments

%idAln lengthE-value
MIA_06209_185.51%4830.0MIA_06209_1
A0A0J9XEN0_GEOCN86.28%4520.0Similar to Saccharomyces cerevisiae YDR172W SUP35 Translation termination factor eRF3 OS=Geotrichum candidum GN=BN980_GECA10s03948g PE=4 SV=1
A0A1E3PR76_9ASCO79.38%4510.0Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81851 PE=4 SV=1
Q59YE8_CANAL81.15%4510.0Translation termination factor GTPase eRF3 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SUP35 PE=4 SV=1
A0A161HH30_9ASCO77.83%4510.0Translation termination factor GTPase eRF3 OS=Sugiyamaella lignohabitans GN=SUP35 PE=4 SV=1
A0A060T886_BLAAD79.27%4390.0ARAD1C34716p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C34716g PE=4 SV=1
UniRef50_Q9HGI476.05%4510.0Eukaryotic peptide chain release factor GTP-binding subunit n=377 Tax=Fungi TaxID=4751 RepID=ERF3_ZYGRO
ERF3_YEAST76.50%4340.0Eukaryotic peptide chain release factor GTP-binding subunit OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SUP35 PE=1 SV=1
Q6CFC9_YARLI72.44%4390.0YALI0B08250p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B08250g PE=4 SV=1
A0A1E4THS4_9ASCO69.79%4270.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2943 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0364

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 725

Detailed signature matches

  1. Family IPR003285
    Eukaryotic peptide chain release factor GTP-binding subunit
    1. PR01343 (YEASTERF)
  2. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  3. Domain IPR000795
    Transcription factor, GTP-binding domain
    1. PS51722 (G_TR_2)
    2. PF00009 (GTP_EFTU)
    3. PR00315 (ELONGATNFCT)
  4. Domain IPR009000
    Translation protein, beta-barrel domain
    1. SSF50447 (Translati...)
  5. Domain IPR004161
    Translation elongation factor EFTu-like, domain 2
    1. PF03144 (GTP_EFTU_D2)
  6. Domain IPR009001
    Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
    1. SSF50465 (EF-Tu/eEF...)
  7. Domain IPR004160
    Translation elongation factor EFTu/EF1A, C-terminal
    1. PF03143 (GTP_EFTU_D3)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:2.40.30.10
  2. G3DSA:3.40.50...
  3. cd01883 (EF1_alpha)
  4. cd03704 (eRF3_C_III)
  5. cd04089 (eRF3_II)
  6. mobidb-lite (disord...)

Residue annotation

  1. G1 box cd01883
  2. putative GEF inter...
  3. GTP/Mg2+ binding s...
  4. EF1Balpha binding ...
  5. Switch I region cd...
  6. G2 box cd01883
  7. G3 box cd01883
  8. Switch II region c...
  9. G4 box cd01883
  10. G5 box cd01883
  11. 18S rRNA binding s...
  12. heterodimer interf...

Protein sequence

>MCA_03611_1
MSNNQNDNTDERLAQDFQNQAQIGGGAQQQQQPNQFSYNPNAATPSFTPGQGFYPQFQQGYQQQPQGYQQYQQGYQQYPP
QNFQQGGFQPGFQQGNYQQGGYQGGYQQQQGNYRGNYRGRGRGGNYRGRGGYNNYNNNYNNNYNNNRSNQSEEKTLTLEE
YKKQQQAALNAPIIKKTVPKPAAETKPAEEKPETSKPEEEETKPAPKEEEPKSAPKEEEPKLAAKEEPKSEPKETESKPE
PVAEAKNAESTEKPASSDSKADSTTSTTQSANALVKEQEEEIDEEVISDLFGAGGQGKDHMSIIFMGHVDAGKSTMGGNI
LYLTGSVDKRTVEKYEREAKDAGRQGWYLSWVMDTNKEERAEGKTVEVGRAYFETEKRRYTILDAPGHKMYVPSMIGGAS
QADVGILVISARKGEYETGFEKGGQTREHAILAKTQGVNRLIVVVNKMDDPTVQWSKERYDECTSKLANFLKGTGYNLKT
DVHMMPVSGYTGAGLKERVSKTDCPWYDGPSLLEYLDALPLANRKIGAPFMLPISGKGKDLGTIIEGKIESGAVKKGQQL
LVMPNKTQVEVLAVFNETEAEVNGAVSGEQVRIRVKGIEEEDLSIGYVLSSLKHPVHTVTRFEAQVAIVELNSILAKGFS
CVMHVHTAIEEVTFSELLHKLQKGTNRKSKKPPAFAKKGMKIIAILETEEPVCVETYDDHPQLGRFTLRDQGTTIAIGKI
TKLLN

GO term prediction

Biological Process

GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0006415 translational termination

Molecular Function

GO:0003747 translation release factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding

Cellular Component

None predicted.