Protein

MCA_03610_1

Length
999 amino acids

Gene name: KGD1

Description: 2-oxoglutarate dehydrogenase, mitochondrial

Browser: contigC:532580-536256-

RNA-seq: read pairs 27567, FPKM 340.6, percentile rank 92.6% (100% = highest expression)

Protein function

Annotation:KGD12-oxoglutarate dehydrogenase, mitochondrial
KEGG:K00164OGDH 2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]
EGGNOG:0PFJNKGD12-oxoglutarate dehydrogenase E1 component
SGD closest match:S000001387KGD12-oxoglutarate dehydrogenase, mitochondrial
CGD closest match:CAL0000193211KGD1Alpha-ketoglutarate dehydrogenase

Protein alignments

%idAln lengthE-value
MIA_05103_184.68%9790.0MIA_05103_1
A0A0J9XJ05_GEOCN79.98%9840.0Similar to Saccharomyces cerevisiae YIL125W KGD1 Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle OS=Geotrichum candidum GN=BN980_GECA21s01462g PE=4 SV=1
A0A167EFJ7_9ASCO73.56%9570.0Alpha-ketoglutarate dehydrogenase KGD1 OS=Sugiyamaella lignohabitans GN=KGD1 PE=4 SV=1
Q6C3M8_YARLI70.56%9850.0YALI0E33517p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E33517g PE=4 SV=2
UniRef50_A3LZW871.11%9760.0Alpha-ketoglutarate dehydrogenase n=18 Tax=Dikarya TaxID=451864 RepID=A3LZW8_PICST
A0A060T3S5_BLAAD70.07%9690.0ARAD1A11814p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A11814g PE=4 SV=1
A0A1E4TEL1_9ASCO71.03%9770.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_31230 PE=4 SV=1
A0A1E3PSV3_9ASCO69.21%9680.02-oxoglutarate dehydrogenase E1 component mitochondrial OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_44954 PE=4 SV=1
A0A1D8PJ26_CANAL69.40%9640.0Alpha-ketoglutarate dehydrogenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=KGD1 PE=4 SV=1
ODO1_YEAST68.30%9780.02-oxoglutarate dehydrogenase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=KGD1 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9997
Predicted cleavage: 13

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 700 800 900 999

Detailed signature matches

  1. Family IPR011603
    2-oxoglutarate dehydrogenase E1 component
    1. PIRSF000157 (Oxoglu...)
    2. TIGR00239
  2. Domain IPR032106
    2-oxoglutarate dehydrogenase E1 component, N-terminal domain
    1. PF16078 (2-oxogl_de...)
  3. Domain IPR029061
    Thiamin diphosphate-binding fold
    1. SSF52518 (Thiamin d...)
  4. Domain IPR001017
    Dehydrogenase, E1 component
    1. PF00676 (E1_dh)
  5. Domain IPR005475
    Transketolase-like, pyrimidine-binding domain
    1. PF02779 (Transket_pyr)
    2. SM00861 (Transket_p...)
  6. Domain IPR031717
    Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal
    1. PF16870 (OxoGdeHyase_C)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.28...
  2. G3DSA:3.40.50...
  3. cd02016 (TPP_E1_OGD...)

Residue annotation

  1. TPP-binding site c...

Protein sequence

>MCA_03610_1
MLRNLSRSSRSLLSRNTLRQSITRSTLGSYVQRSSFATGGDDVFLSTANANYIDEMYSAWKQDPSSVHVSWQSYFRNLES
GAPSSQAFQAPPTIVPSNNASVTPGAGNGIADHMKVQLLVRAYQVRGHIRAKTDPLEISFGYDTKVPPPKELTPEFYGFT
EADLDKEIALGPGILPRFATNGKSSMTIREIIAACEKTYCGSYGVEYMHIPSREQCDWIRERVEIPQPYTFPVDEKRRIL
DRTIWAVLFESFLATKFPNDKRFGLEGAEATIPAMKILIDESVEHGVEDIVIGMPHRGRLNMLSNVVRKPNESILSEFSG
SASFDTGSGDVKYHLGANYQRPTPSGKKVNLSLVANPSHLEAEDPVVLGKTRAIQFYKNDEKEGTKAMAILLHGDAAFAG
QGVVYECFGFKNLPNYSTGGTVHIIVNNQIGFTTDPRFSRSTPYPSDLAKAIDAPIFHVNADDVEGMYYIFKLAAEWRAK
FKSDVVIDVVCYRKYGHNETDQPSFTQPLMYKKISQKKSVLDIYTDKLIKEGTFTKEDIEEHKKWVWGNLEDAFANSKDY
VPSQKEWLASAWDGFKTPKELATEILPHLPTAVDVETLKHIGKVISTPPEGFQLHRNLKRILNNRLKTVEEGKNIDWSTG
EALAFGSLLKEGYHIRVSGEDVERGTFSQRHAVLHDQETEETYTPLQHAFKDQAAFHISNSSLSEYGVMGFEYGYSLYNP
DALVMWEAQFGDFANTGQVITDLFVAAGEQKWAQRSGLVMSLPHGFDGQGPDHSSSRLERFLALCNEDPRKFPTEDALQR
QHQDANMQVVYPTTPANLFHILRRQMLRQFRKPLILLFSKSLLRHPLARSPIEDFTGDSTFKWIIEDPAELPKEQVKRVI
FCSGQVFTALTKARETNNVKDTTLVRIEQLHPFPFAQVRDLLNSYPNLTDICWCQEEPLNMGAYSYATQRLHTIFRTTEK
YKNNTVRYIGRDPNPGVAAGSKKLHHDEEEAFLKDAFQL

GO term prediction

Biological Process

GO:0006099 tricarboxylic acid cycle
GO:0008152 metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity
GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO:0030976 thiamine pyrophosphate binding

Cellular Component

None predicted.